Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /GNAT-DUF1778
Location 392535..393301 Replicon chromosome
Accession NZ_LT992489
Organism Vibrio cholerae strain 4295STDY6534232

Toxin (Protein)


Gene name - Uniprot ID Q9K2P7
Locus tag DG176_RS16155 Protein ID WP_000982260.1
Coordinates 392804..393301 (+) Length 166 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q9K2J6
Locus tag DG176_RS16150 Protein ID WP_000246253.1
Coordinates 392535..392807 (+) Length 91 a.a.

Genomic Context

DG176_RS16150DG176_RS16155DG176_RS16105DG176_RS16110DG176_RS16115DG176_RS16125DG176_RS16130DG176_RS16135DG176_RS16140DG176_RS16145DG176_RS16165DG176_RS16170DG176_RS16175DG176_RS16180DG176_RS16185DG176_RS16190DG176_RS16195DG176_RS16200DG176_RS16205
Location: 392535..392807 (273 bp)
Type: Antitoxin
Protein ID: WP_000246253.1
Location: 392804..393301 (498 bp)
Type: Toxin
Protein ID: WP_000982260.1
Location: 387763..388680 (918 bp)
Type: Others
Protein ID: WP_000186333.1
Location: 388914..389216 (303 bp)
Type: Others
Protein ID: WP_000229317.1
Location: 389204..389461 (258 bp)
Type: Others
Protein ID: WP_000861987.1
Location: 389663..390196 (534 bp)
Type: Others
Protein ID: WP_000118351.1
Location: 390193..390618 (426 bp)
Type: Others
Protein ID: WP_001882332.1
Location: 390685..391056 (372 bp)
Type: Others
Protein ID: WP_001164080.1
Location: 391197..391484 (288 bp)
Type: Others
Protein ID: WP_000426470.1
Location: 391636..392304 (669 bp)
Type: Others
Protein ID: WP_000043871.1
Location: 393503..393655 (153 bp)
Type: Others
Protein ID: WP_001884520.1
Location: 393977..394432 (456 bp)
Type: Others
Protein ID: WP_001245327.1
Location: 394560..394847 (288 bp)
Type: Others
Protein ID: WP_000221354.1
Location: 394837..395088 (252 bp)
Type: Others
Protein ID: WP_001250179.1
Location: 395302..395715 (414 bp)
Type: Others
Protein ID: WP_000049417.1
Location: 395790..395933 (144 bp)
Type: Others
Protein ID: WP_071908341.1
Location: 395903..396304 (402 bp)
Type: Others
Protein ID: WP_000351248.1
Location: 396304..396996 (693 bp)
Type: Others
Protein ID: WP_001047169.1
Location: 397133..397439 (307 bp)
Type: Others
Protein ID: Protein_349
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
DG176_RS16105387763..388680-918WP_000186333.1alpha/beta hydrolase-
DG176_RS16110388914..389216-303WP_000229317.1type II toxin-antitoxin system RelE/ParE family toxin-
DG176_RS16115389204..389461-258WP_000861987.1type II toxin-antitoxin system Phd/YefM family antitoxin-
DG176_RS16125389663..390196-534WP_000118351.1GNAT family N-acetyltransferase-
DG176_RS16130390193..390618-426WP_001882332.1DUF1778 domain-containing protein-
DG176_RS16135390685..391056-372WP_001164080.1nucleotide pyrophosphohydrolase-
DG176_RS16140391197..391484-288WP_000426470.1hypothetical protein-
DG176_RS16145391636..392304-669WP_000043871.1hypothetical protein-
DG176_RS16150392535..392807+273WP_000246253.1DUF1778 domain-containing proteinAntitoxin
DG176_RS16155392804..393301+498WP_000982260.1GNAT family N-acetyltransferaseToxin
DG176_RS16165393503..393655-153WP_001884520.1DUF645 family protein-
DG176_RS16170393977..394432-456WP_001245327.1GNAT family N-acetyltransferase-
DG176_RS16175394560..394847-288WP_000221354.1type II toxin-antitoxin system RelE/ParE family toxin-
DG176_RS16180394837..395088-252WP_001250179.1type II toxin-antitoxin system Phd/YefM family antitoxin-
DG176_RS16185395302..395715-414WP_000049417.1VOC family protein-
DG176_RS16190395790..395933-144WP_071908341.1DUF3265 domain-containing protein-
DG176_RS16195395903..396304-402WP_000351248.1type II toxin-antitoxin system death-on-curing family toxin-
DG176_RS16200396304..396996-693WP_001047169.1GNAT family N-acetyltransferase-
DG176_RS16205397133..397439-307Protein_349CatB-related O-acetyltransferase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-379325..47629796972
flankIS/Tn--397507..398487980
insideIntegroncatB9-379701..46950989808


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(86-152)

Antitoxin

Vibrio phage ICP1, Orf50

(7-86)


Sequences

Toxin        


Download         Length: 166 a.a.        Molecular weight: 18527.18 Da        Isoelectric Point: 8.7753

>T294373 WP_000982260.1 NZ_LT992489:392804-393301 [Vibrio cholerae]
MMNTVLLDKDKHDRNRFNCGTEALNNYLKVMASQQAKKDNTRTFVLEDDNNSAYIIGFYTLTMTPIDLKALPDKLQKKHQ
SSTSGGLIARLAVDDRYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKHFYERYGFQAFQDAENKLFITIADI
RASLG

Download         Length: 498 bp

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9683.22 Da        Isoelectric Point: 6.2988

>AT294373 WP_000246253.1 NZ_LT992489:392535-392807 [Vibrio cholerae]
MATTLPRITARVDVDTQDLLAKAAALAGMSSINSFVLNAAIEKAKQVIEREQALKLSQADAVLLMEALDNPAVVNAKLKL
ASERYESKTQ

Download         Length: 273 bp


Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0Q0KGB1

Antitoxin

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Source
ID
Structure
PDB1Y9B
AlphaFold DBA0A0F2IC79

References