38681

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /BrnT(toxin)
Location 289531..290029 Replicon chromosome
Accession NZ_AP024554
Organism Vibrio cholerae strain IDH-03329

Toxin (Protein)


Gene name - Uniprot ID Q9KMK7
Locus tag K6J80_RS15445 Protein ID WP_000589156.1
Coordinates 289763..290029 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q9KMK6
Locus tag K6J80_RS15440 Protein ID WP_000643598.1
Coordinates 289531..289776 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6J80_RS15400 284612..284998 - 387 WP_000703163.1 VOC family protein -
K6J80_RS15405 285155..285661 - 507 WP_000393074.1 hypothetical protein -
K6J80_RS19065 286183..286368 - 186 WP_001999468.1 hypothetical protein -
K6J80_RS15415 286435..286794 - 360 WP_001071541.1 VOC family protein -
K6J80_RS15420 286947..287951 - 1005 WP_000964920.1 LD-carboxypeptidase -
K6J80_RS15425 288167..288349 - 183 WP_000923182.1 DUF645 family protein -
K6J80_RS15430 288410..288538 - 129 WP_071908338.1 general secretion pathway protein GspI -
K6J80_RS19070 288528..288644 - 117 WP_086010881.1 DUF3265 domain-containing protein -
K6J80_RS15435 288641..289435 - 795 WP_001911581.1 hypothetical protein -
K6J80_RS15440 289531..289776 - 246 WP_000643598.1 hypothetical protein Antitoxin
K6J80_RS15445 289763..290029 - 267 WP_000589156.1 BrnT family toxin Toxin
K6J80_RS19075 290096..290224 - 129 WP_088124358.1 DUF3265 domain-containing protein -
K6J80_RS15450 290214..290876 - 663 WP_000960654.1 hypothetical protein -
K6J80_RS15455 291004..291471 - 468 WP_001289288.1 OsmC family protein -
K6J80_RS19080 291643..291774 - 132 WP_001883067.1 hypothetical protein -
K6J80_RS15470 292293..292571 - 279 WP_000280324.1 DUF3709 domain-containing protein -
K6J80_RS15475 292823..293065 - 243 WP_000107461.1 hypothetical protein -
K6J80_RS19085 293157..293306 - 150 WP_071908333.1 DUF3265 domain-containing protein -
K6J80_RS15480 293279..293530 - 252 WP_001890111.1 TIGR03643 family protein -
K6J80_RS15485 293725..294111 - 387 WP_000703163.1 VOC family protein -
K6J80_RS15490 294101..294202 - 102 WP_001921603.1 hypothetical protein -
K6J80_RS19090 294402..294500 - 99 WP_223225486.1 DUF3709 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 213119..319686 106567
inside Integron - - 213119..312856 99737


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(6-81)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10092.34 Da        Isoelectric Point: 7.3171

>T38681 WP_000589156.1 NZ_AP024554:c290029-289763 [Vibrio cholerae]
MIKFEFDENKSRSNLEKHGIDFHTAQGLWNDSDLIEIPANTSDEPRYLVVGLLNGKHWSGVITYRGTNIRIISVRRSRKA
EVSLYESA

Download         Length: 267 bp

>T38681 NZ_AP024554:c290029-289763 [Vibrio cholerae]
ATGATTAAATTTGAATTTGATGAAAACAAAAGCAGAAGTAATCTCGAAAAGCACGGTATTGATTTTCATACAGCTCAAGG
ATTGTGGAATGATTCAGATCTTATCGAGATCCCTGCTAACACGAGTGATGAGCCCAGATATTTGGTTGTCGGCTTACTAA
ACGGTAAGCATTGGTCAGGAGTAATTACCTACCGAGGTACGAATATCAGGATCATCTCAGTTCGGCGTTCACGGAAAGCG
GAGGTAAGCCTTTATGAAAGCGCATGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9478.77 Da        Isoelectric Point: 6.4832

>AT38681 WP_000643598.1 NZ_AP024554:c289776-289531 [Vibrio cholerae]
MKAHEFDAKFESDDDDIVMDLDLSQAKRPMHKQKRVNVDFPAWMLESLDREASRIGVTRQSIIKIWLAERLESVSHHSSV
R

Download         Length: 246 bp

>AT38681 NZ_AP024554:c289776-289531 [Vibrio cholerae]
ATGAAAGCGCATGAATTTGATGCCAAGTTTGAAAGTGACGACGATGATATCGTAATGGACTTGGATCTATCGCAAGCTAA
AAGACCGATGCATAAGCAAAAACGAGTCAATGTAGATTTTCCAGCCTGGATGCTTGAGTCCTTGGACAGAGAAGCGAGTC
GTATTGGTGTAACACGTCAATCAATCATTAAAATTTGGCTGGCAGAAAGGTTAGAGAGCGTGTCTCATCATTCAAGTGTG
AGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A271VMP7

Antitoxin

Source ID Structure
AlphaFold DB A0A271VME2

References