Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-Phd
Location 401002..401549 Replicon chromosome
Accession NZ_CP006948
Organism Vibrio cholerae O1 str. KW3

Toxin (Protein)


Gene name relE Uniprot ID Q9KM92
Locus tag N900_RS16085 Protein ID WP_000229317.1
Coordinates 401247..401549 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9KM93
Locus tag N900_RS16080 Protein ID WP_000861987.1
Coordinates 401002..401259 (+) Length 86 a.a.

Genomic Context

N900_RS16035N900_RS16040N900_RS16055N900_RS16060N900_RS16065N900_RS16070N900_RS16075N900_RS16080N900_RS16085N900_RS16090N900_RS16095N900_RS16100N900_RS16105N900_RS16110N900_RS16115N900_RS16120N900_RS20070N900_RS16045N900_RS16050
Location: 396031..396486 (456 bp)
Type: Others
Protein ID: WP_001245327.1
Location: 396808..396960 (153 bp)
Type: Others
Protein ID: WP_001884520.1
Location: 398159..398827 (669 bp)
Type: Others
Protein ID: WP_000043871.1
Location: 398979..399266 (288 bp)
Type: Others
Protein ID: WP_000426470.1
Location: 399407..399778 (372 bp)
Type: Others
Protein ID: WP_001164080.1
Location: 399845..400270 (426 bp)
Type: Others
Protein ID: WP_001882332.1
Location: 400267..400800 (534 bp)
Type: Others
Protein ID: WP_000118351.1
Location: 401002..401259 (258 bp)
Type: Antitoxin
Protein ID: WP_000861987.1
Location: 401247..401549 (303 bp)
Type: Toxin
Protein ID: WP_000229317.1
Location: 401783..402699 (917 bp)
Type: Others
Protein ID: Protein_421
Location: 402856..403245 (390 bp)
Type: Others
Protein ID: WP_001081302.1
Location: 403381..403590 (210 bp)
Type: Others
Protein ID: Protein_423
Location: 403709..404146 (438 bp)
Type: Others
Protein ID: WP_000503169.1
Location: 404210..404428 (219 bp)
Type: Others
Protein ID: WP_071908318.1
Location: 404603..405475 (873 bp)
Type: Others
Protein ID: WP_000254716.1
Location: 405625..406224 (600 bp)
Type: Others
Protein ID: WP_001891245.1
Location: 406281..406385 (105 bp)
Type: Others
Protein ID: WP_099607150.1
Location: 397162..397659 (498 bp)
Type: Others
Protein ID: WP_000982260.1
Location: 397656..397928 (273 bp)
Type: Others
Protein ID: WP_000246253.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
N900_RS16035396031..396486+456WP_001245327.1GNAT family N-acetyltransferase-
N900_RS16040396808..396960+153WP_001884520.1DUF645 family protein-
N900_RS16045397162..397659-498WP_000982260.1GNAT family N-acetyltransferase-
N900_RS16050397656..397928-273WP_000246253.1DUF1778 domain-containing protein-
N900_RS16055398159..398827+669WP_000043871.1hypothetical protein-
N900_RS16060398979..399266+288WP_000426470.1hypothetical protein-
N900_RS16065399407..399778+372WP_001164080.1nucleotide pyrophosphohydrolase-
N900_RS16070399845..400270+426WP_001882332.1DUF1778 domain-containing protein-
N900_RS16075400267..400800+534WP_000118351.1GNAT family N-acetyltransferase-
N900_RS16080401002..401259+258WP_000861987.1type II toxin-antitoxin system Phd/YefM family antitoxinAntitoxin
N900_RS16085401247..401549+303WP_000229317.1type II toxin-antitoxin system RelE/ParE family toxinToxin
N900_RS16090401783..402699+917Protein_421alpha/beta hydrolase-
N900_RS16095402856..403245+390WP_001081302.1hypothetical protein-
N900_RS16100403381..403590+210Protein_423GNAT family N-acetyltransferase-
N900_RS16105403709..404146+438WP_000503169.1IS200/IS605-like element IS1004 family transposase-
N900_RS16110404210..404428+219WP_071908318.1GNAT family N-acetyltransferase-
N900_RS16115404603..405475+873WP_000254716.1DUF3800 domain-containing protein-
N900_RS16120405625..406224+600WP_001891245.1glutathione S-transferase N-terminal domain-containing protein-
N900_RS20070406281..406385+105WP_099607150.1acetyltransferase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-304645..411088106443
insideIntegron--309725..410760101035
flankIS/Tn--403709..404146437


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-69)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11726.68 Da        Isoelectric Point: 5.1972

>T45816 WP_000229317.1 NZ_CP006948:401247-401549 [Vibrio cholerae O1 str. KW3]
MVEIIWTELALSDLNDIAEYIALENVVAAKQLVQTVFTKVERLADFPESGRVPPELEHLNYREVVVSPCRVFYKYDDAKV
RILFVMRAERDLRRLMLTKQ

Download         Length: 303 bp

>T45816 NZ_CP006948:401247-401549 [Vibrio cholerae O1 str. KW3]
ATGGTTGAAATAATTTGGACGGAGCTGGCTCTATCCGACTTGAATGATATTGCTGAATACATCGCGCTTGAAAATGTCGT
GGCTGCTAAACAACTGGTGCAAACCGTTTTTACAAAAGTTGAACGTTTGGCCGATTTTCCAGAGTCTGGGCGCGTCCCTC
CAGAACTAGAACACCTCAATTATCGTGAAGTCGTTGTAAGTCCGTGTCGTGTTTTCTACAAGTATGATGATGCAAAGGTT
CGTATTCTTTTTGTTATGCGTGCGGAGCGAGATTTGCGTCGGTTAATGCTTACGAAACAGTAG

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9647.15 Da        Isoelectric Point: 7.3178

>AT45816 WP_000861987.1 NZ_CP006948:401002-401259 [Vibrio cholerae O1 str. KW3]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLIDVDDYEFMQNRLAILEGIARGERALADGKVVSHQDAKDRM
SKWLK

Download         Length: 258 bp

>AT45816 NZ_CP006948:401002-401259 [Vibrio cholerae O1 str. KW3]
ATGAAAGTAGAACTTGTGACGTCACTAAAACGTCAGGCCACTAAGATCCTTGCCGATCTTCATGATACGAAAGAGCCAGT
ATTGATAACTGAGCACGGAAAACCGTCAGCTTACCTTATTGATGTAGACGACTATGAATTTATGCAAAATCGTTTAGCGA
TCCTGGAAGGTATTGCTCGCGGAGAGCGAGCTTTAGCGGATGGTAAAGTGGTCAGCCATCAAGATGCTAAGGACAGAATG
TCAAAATGGTTGAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBQ9KM92

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A1T4SLM9

References