74630

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /GNAT-DUF1778
Location 858197..858963 Replicon chromosome
Accession NZ_CP020407
Organism Vibrio cholerae strain FDAARGOS_223

Toxin (Protein)


Gene name - Uniprot ID Q9K2P7
Locus tag A6J62_RS04515 Protein ID WP_000982260.1
Coordinates 858466..858963 (+) Length 166 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q9K2J6
Locus tag A6J62_RS04510 Protein ID WP_000246253.1
Coordinates 858197..858469 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A6J62_RS04450 853694..853936 - 243 WP_000107461.1 hypothetical protein -
A6J62_RS04455 854028..854177 - 150 WP_071908333.1 DUF3265 domain-containing protein -
A6J62_RS04460 854150..854401 - 252 WP_001890111.1 TIGR03643 family protein -
A6J62_RS04465 854596..854982 - 387 WP_000703163.1 VOC family protein -
A6J62_RS04470 854972..855073 - 102 WP_001921603.1 hypothetical protein -
A6J62_RS19590 855273..855479 - 207 Protein_821 DUF3709 domain-containing protein -
A6J62_RS04475 855731..856009 - 279 WP_001921601.1 DUF3709 domain-containing protein -
A6J62_RS04485 856295..856573 + 279 WP_001258569.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
A6J62_RS04490 856566..856835 + 270 WP_000277238.1 type II toxin-antitoxin system YafQ family toxin -
A6J62_RS04495 856983..857429 - 447 WP_000006157.1 hypothetical protein -
A6J62_RS19595 857625..857663 - 39 WP_106019118.1 hypothetical protein -
A6J62_RS04505 857679..857804 - 126 WP_001900195.1 DUF645 family protein -
A6J62_RS04510 858197..858469 + 273 WP_000246253.1 DUF1778 domain-containing protein Antitoxin
A6J62_RS04515 858466..858963 + 498 WP_000982260.1 GNAT family N-acetyltransferase Toxin
A6J62_RS04520 859113..859628 - 516 WP_001201509.1 lipocalin family protein -
A6J62_RS04525 859765..860301 - 537 WP_000469482.1 GNAT family N-acetyltransferase -
A6J62_RS04540 860559..860840 - 282 WP_001894429.1 DUF1289 domain-containing protein -
A6J62_RS04545 860789..860902 - 114 WP_001900214.1 hypothetical protein -
A6J62_RS04550 860959..861345 - 387 WP_001015867.1 NUDIX hydrolase -
A6J62_RS04555 861589..861831 + 243 WP_000557292.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
A6J62_RS04560 861850..862167 + 318 WP_001180243.1 type II toxin-antitoxin system RelE/ParE family toxin -
A6J62_RS04570 862321..862659 - 339 WP_000713853.1 hypothetical protein -
A6J62_RS04575 862817..863521 - 705 WP_000087610.1 HNH endonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 749087..881909 132822
inside Integron - - 749463..875103 125640


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(86-152)

Antitoxin

Vibrio phage ICP1, Orf50

(7-86)


Sequences

Toxin        


Download         Length: 166 a.a.        Molecular weight: 18527.18 Da        Isoelectric Point: 8.7753

>T74630 WP_000982260.1 NZ_CP020407:858466-858963 [Vibrio cholerae]
MMNTVLLDKDKHDRNRFNCGTEALNNYLKVMASQQAKKDNTRTFVLEDDNNSAYIIGFYTLTMTPIDLKALPDKLQKKHQ
SSTSGGLIARLAVDDRYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKHFYERYGFQAFQDAENKLFITIADI
RASLG

Download         Length: 498 bp

>T74630 NZ_CP020407:858466-858963 [Vibrio cholerae]
ATGATGAATACGGTACTTCTCGATAAAGATAAGCACGATAGGAACCGTTTCAATTGTGGCACTGAAGCACTCAACAATTA
CTTAAAAGTAATGGCGAGTCAGCAAGCCAAAAAAGACAACACCAGAACCTTCGTTTTGGAAGATGACAATAACAGTGCTT
ATATCATCGGCTTTTACACTCTGACTATGACGCCCATTGATTTGAAAGCCTTGCCCGACAAGTTACAAAAGAAGCACCAA
TCCTCAACCTCTGGAGGGCTCATTGCTCGTTTAGCTGTCGACGATAGATACAAAGGAAAAGGTTTTGGTGAGTGGCTACT
CATTGACGCTCTCAGAAAGCTACTCGCAGCCAGTGACAGTGTAGCGTTCCCTGTTGTCATTGTTGATGCCAAAGATGGTG
CAAAACATTTCTATGAGCGCTATGGGTTTCAAGCGTTTCAAGATGCCGAAAACAAACTCTTCATCACCATTGCTGATATC
AGAGCAAGCTTAGGCTAG

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9683.22 Da        Isoelectric Point: 6.2988

>AT74630 WP_000246253.1 NZ_CP020407:858197-858469 [Vibrio cholerae]
MATTLPRITARVDVDTQDLLAKAAALAGMSSINSFVLNAAIEKAKQVIEREQALKLSQADAVLLMEALDNPAVVNAKLKL
ASERYESKTQ

Download         Length: 273 bp

>AT74630 NZ_CP020407:858197-858469 [Vibrio cholerae]
ATGGCAACGACTTTGCCTCGCATCACCGCTAGAGTTGATGTCGATACTCAAGATTTACTCGCTAAGGCTGCTGCTCTTGC
TGGTATGTCTAGTATTAACTCATTTGTTTTGAATGCAGCAATCGAAAAAGCAAAACAAGTCATTGAACGTGAGCAAGCTC
TAAAGCTTAGCCAAGCTGATGCCGTATTGCTGATGGAAGCTCTTGATAATCCAGCTGTAGTAAATGCAAAGCTCAAATTG
GCATCCGAACGTTATGAGAGCAAAACTCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Q0KGB1

Antitoxin

Source ID Structure
AlphaFold DB A0A0F2IC79

References