Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | parDE/ParE-RHH |
| Location | 383126..383664 | Replicon | chromosome |
| Accession | NZ_CP046841 | ||
| Organism | Vibrio cholerae strain F9993 | ||
Toxin (Protein)
| Gene name | parE | Uniprot ID | Q9KMJ0 |
| Locus tag | GPY07_RS16295 | Protein ID | WP_000802136.1 |
| Coordinates | 383365..383664 (+) | Length | 100 a.a. |
Antitoxin (Protein)
| Gene name | parD | Uniprot ID | P58093 |
| Locus tag | GPY07_RS16290 | Protein ID | WP_001107719.1 |
| Coordinates | 383126..383368 (+) | Length | 81 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| GPY07_RS16245 | 378542..378682 | - | 141 | WP_001883049.1 | DUF3265 domain-containing protein | - |
| GPY07_RS16250 | 378648..379583 | - | 936 | WP_000051985.1 | restriction endonuclease | - |
| GPY07_RS16255 | 379864..380463 | - | 600 | WP_000429495.1 | hypothetical protein | - |
| GPY07_RS16260 | 380618..380884 | - | 267 | WP_000937852.1 | hypothetical protein | - |
| GPY07_RS16265 | 381098..381781 | - | 684 | WP_000877436.1 | hypothetical protein | - |
| GPY07_RS16275 | 382205..382297 | - | 93 | WP_014164112.1 | DUF3265 domain-containing protein | - |
| GPY07_RS16280 | 382319..382897 | - | 579 | WP_000110120.1 | hypothetical protein | - |
| GPY07_RS16290 | 383126..383368 | + | 243 | WP_001107719.1 | type II toxin-antitoxin system ParD family antitoxin | Antitoxin |
| GPY07_RS16295 | 383365..383664 | + | 300 | WP_000802136.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| GPY07_RS16300 | 383792..384187 | - | 396 | WP_000870857.1 | DUF3465 domain-containing protein | - |
| GPY07_RS16305 | 384401..384580 | - | 180 | WP_001883058.1 | DUF645 family protein | - |
| GPY07_RS16315 | 385158..385268 | - | 111 | WP_079857360.1 | DUF3265 domain-containing protein | - |
| GPY07_RS16320 | 385278..385976 | - | 699 | WP_001890502.1 | hypothetical protein | - |
| GPY07_RS16325 | 386099..386725 | - | 627 | WP_000365424.1 | LysE family translocator | - |
| GPY07_RS16330 | 386767..386859 | - | 93 | WP_014378730.1 | DUF3265 domain-containing protein | - |
| GPY07_RS16335 | 386874..387347 | - | 474 | WP_001161076.1 | GrpB family protein | - |
| GPY07_RS16340 | 387547..387729 | - | 183 | WP_000923182.1 | DUF645 family protein | - |
| GPY07_RS19455 | 387790..387918 | - | 129 | WP_071908338.1 | general secretion pathway protein GspI | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | catB9 | - | 322056..419024 | 96968 | |
| inside | Integron | - | - | 322432..412236 | 89804 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 100 a.a. Molecular weight: 11589.29 Da Isoelectric Point: 9.9232
>T145068 WP_000802136.1 NZ_CP046841:383365-383664 [Vibrio cholerae]
MKPFNLTVAAKADLRDIALFTQRRWGKEQRNVYLKQFDDSFWLLAENPDIGKSCDEIREGYRKFPQGSHVIFYQQTGSQQ
IRVIRILHKSMDVNPIFGA
MKPFNLTVAAKADLRDIALFTQRRWGKEQRNVYLKQFDDSFWLLAENPDIGKSCDEIREGYRKFPQGSHVIFYQQTGSQQ
IRVIRILHKSMDVNPIFGA
Download Length: 300 bp
>T145068 NZ_CP062253:c1841602-1841099 [Pseudomonas gozinkensis]
ATGTGGCTTGCCCTCTCAGGACGATTTCGCGCGCGATGGACCCAGGAGATTCACTGCGAATGGAAACGCAATCTGCTGAA
GAACCGCCCTGACCTGACGATGGAACAGCTGGATCGTACGTCCGGCCTGATGGATCAAGCGATACCCGACGCCTGTGTCC
ATGACTATGAAGATCTGATCGCCGGACTCACCTTGCCCGACTGCGATGATCGTCATGTTCTGGCAGCGGCCATCCGCTGC
GGCGCAAGCGTGATAGTGACGTTCAACCAGAAAGACTTTCCCTGCAAAGCGCTGGAGCCTTTCGGCATCGAAGCGCAACA
TCCGGACGAGTTCGTCGACAACCTCTTGGGGCTTGATCCGGCAGCAGTGGTTGCAGCGGCCCAAAAGCAGCGTCGGCAGC
TGAAAATGCCTGCCATGGACGTCGAACCCTTTCTTGATCTACTGCAACGACAAGGCCTGATTAAATCGGCCCAGGCACTG
AGCGGCTATCACGCGATTCTTTGA
ATGTGGCTTGCCCTCTCAGGACGATTTCGCGCGCGATGGACCCAGGAGATTCACTGCGAATGGAAACGCAATCTGCTGAA
GAACCGCCCTGACCTGACGATGGAACAGCTGGATCGTACGTCCGGCCTGATGGATCAAGCGATACCCGACGCCTGTGTCC
ATGACTATGAAGATCTGATCGCCGGACTCACCTTGCCCGACTGCGATGATCGTCATGTTCTGGCAGCGGCCATCCGCTGC
GGCGCAAGCGTGATAGTGACGTTCAACCAGAAAGACTTTCCCTGCAAAGCGCTGGAGCCTTTCGGCATCGAAGCGCAACA
TCCGGACGAGTTCGTCGACAACCTCTTGGGGCTTGATCCGGCAGCAGTGGTTGCAGCGGCCCAAAAGCAGCGTCGGCAGC
TGAAAATGCCTGCCATGGACGTCGAACCCTTTCTTGATCTACTGCAACGACAAGGCCTGATTAAATCGGCCCAGGCACTG
AGCGGCTATCACGCGATTCTTTGA
Antitoxin
Download Length: 81 a.a. Molecular weight: 8964.84 Da Isoelectric Point: 4.1677
>AT145068 WP_001107719.1 NZ_CP046841:383126-383368 [Vibrio cholerae]
MAKNTSITLGEHFDGFITSQIQSGRYGSASEVIRSALRLLENQETKLQSLRQLLIEGEQSGDADYDLDSFINELDSENIR
MAKNTSITLGEHFDGFITSQIQSGRYGSASEVIRSALRLLENQETKLQSLRQLLIEGEQSGDADYDLDSFINELDSENIR
Download Length: 243 bp
>AT145068 NZ_CP062253:c1842151-1841684 [Pseudomonas gozinkensis]
ATGTCGACCGTTATTCATCCCTCCATCAGCCTCCCCGTAGAACGCGAAGTAAAAGCCGCCATTGAAGGGCAGCGTGCCCT
GGCGGCTTACCTCGCGACCCATTTCGAGACTCAGCACATCCAGATTTTCGACGAACAGAACGAGGCTCATCGCGTCGAAC
TGCCCACCTCGGCCCTGCGCTTGCTGATCGACATTCTGGCTGAGCAGGCAGCCGGCAACGCGGTTCAGGTCGTCCCGGTG
CATGCCGAATTGACGACCCAGGAAGCCGCGGACCTGCTCAACGTCTCACGTCCACACCTCATAAAACTGCTGGAAAGCGG
CGAGTTGTCCTACCACAAAACAGGCAAGCACCGACGTGTGCGTTTTGCCGATCTGATGGACTATAAGACCCGGCGCACCA
CCGCCAGCGAGCAGGCAATGGCGCTTCTCGCAGAGCAAGCTCAGGCGTTAAGGACAGGATACGAGTGA
ATGTCGACCGTTATTCATCCCTCCATCAGCCTCCCCGTAGAACGCGAAGTAAAAGCCGCCATTGAAGGGCAGCGTGCCCT
GGCGGCTTACCTCGCGACCCATTTCGAGACTCAGCACATCCAGATTTTCGACGAACAGAACGAGGCTCATCGCGTCGAAC
TGCCCACCTCGGCCCTGCGCTTGCTGATCGACATTCTGGCTGAGCAGGCAGCCGGCAACGCGGTTCAGGTCGTCCCGGTG
CATGCCGAATTGACGACCCAGGAAGCCGCGGACCTGCTCAACGTCTCACGTCCACACCTCATAAAACTGCTGGAAAGCGG
CGAGTTGTCCTACCACAAAACAGGCAAGCACCGACGTGTGCGTTTTGCCGATCTGATGGACTATAAGACCCGGCGCACCA
CCGCCAGCGAGCAGGCAATGGCGCTTCTCGCAGAGCAAGCTCAGGCGTTAAGGACAGGATACGAGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|