Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 383126..383664 Replicon chromosome
Accession NZ_CP046841
Organism Vibrio cholerae strain F9993

Toxin (Protein)


Gene name parE Uniprot ID Q9KMJ0
Locus tag GPY07_RS16295 Protein ID WP_000802136.1
Coordinates 383365..383664 (+) Length 100 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P58093
Locus tag GPY07_RS16290 Protein ID WP_001107719.1
Coordinates 383126..383368 (+) Length 81 a.a.

Genomic Context

GPY07_RS16290GPY07_RS16295GPY07_RS16245GPY07_RS16250GPY07_RS16255GPY07_RS16260GPY07_RS16265GPY07_RS16275GPY07_RS16280GPY07_RS16300GPY07_RS16305GPY07_RS16315GPY07_RS16320GPY07_RS16325GPY07_RS16330GPY07_RS16335GPY07_RS16340GPY07_RS19455
Location: 383126..383368 (243 bp)
Type: Antitoxin
Protein ID: WP_001107719.1
Location: 383365..383664 (300 bp)
Type: Toxin
Protein ID: WP_000802136.1
Location: 378542..378682 (141 bp)
Type: Others
Protein ID: WP_001883049.1
Location: 378648..379583 (936 bp)
Type: Others
Protein ID: WP_000051985.1
Location: 379864..380463 (600 bp)
Type: Others
Protein ID: WP_000429495.1
Location: 380618..380884 (267 bp)
Type: Others
Protein ID: WP_000937852.1
Location: 381098..381781 (684 bp)
Type: Others
Protein ID: WP_000877436.1
Location: 382205..382297 (93 bp)
Type: Others
Protein ID: WP_014164112.1
Location: 382319..382897 (579 bp)
Type: Others
Protein ID: WP_000110120.1
Location: 383792..384187 (396 bp)
Type: Others
Protein ID: WP_000870857.1
Location: 384401..384580 (180 bp)
Type: Others
Protein ID: WP_001883058.1
Location: 385158..385268 (111 bp)
Type: Others
Protein ID: WP_079857360.1
Location: 385278..385976 (699 bp)
Type: Others
Protein ID: WP_001890502.1
Location: 386099..386725 (627 bp)
Type: Others
Protein ID: WP_000365424.1
Location: 386767..386859 (93 bp)
Type: Others
Protein ID: WP_014378730.1
Location: 386874..387347 (474 bp)
Type: Others
Protein ID: WP_001161076.1
Location: 387547..387729 (183 bp)
Type: Others
Protein ID: WP_000923182.1
Location: 387790..387918 (129 bp)
Type: Others
Protein ID: WP_071908338.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
GPY07_RS16245378542..378682-141WP_001883049.1DUF3265 domain-containing protein-
GPY07_RS16250378648..379583-936WP_000051985.1restriction endonuclease-
GPY07_RS16255379864..380463-600WP_000429495.1hypothetical protein-
GPY07_RS16260380618..380884-267WP_000937852.1hypothetical protein-
GPY07_RS16265381098..381781-684WP_000877436.1hypothetical protein-
GPY07_RS16275382205..382297-93WP_014164112.1DUF3265 domain-containing protein-
GPY07_RS16280382319..382897-579WP_000110120.1hypothetical protein-
GPY07_RS16290383126..383368+243WP_001107719.1type II toxin-antitoxin system ParD family antitoxinAntitoxin
GPY07_RS16295383365..383664+300WP_000802136.1type II toxin-antitoxin system RelE/ParE family toxinToxin
GPY07_RS16300383792..384187-396WP_000870857.1DUF3465 domain-containing protein-
GPY07_RS16305384401..384580-180WP_001883058.1DUF645 family protein-
GPY07_RS16315385158..385268-111WP_079857360.1DUF3265 domain-containing protein-
GPY07_RS16320385278..385976-699WP_001890502.1hypothetical protein-
GPY07_RS16325386099..386725-627WP_000365424.1LysE family translocator-
GPY07_RS16330386767..386859-93WP_014378730.1DUF3265 domain-containing protein-
GPY07_RS16335386874..387347-474WP_001161076.1GrpB family protein-
GPY07_RS16340387547..387729-183WP_000923182.1DUF645 family protein-
GPY07_RS19455387790..387918-129WP_071908338.1general secretion pathway protein GspI-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-322056..41902496968
insideIntegron--322432..41223689804


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-92)

Antitoxin

Antitoxin ParD

(1-79)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11589.29 Da        Isoelectric Point: 9.9232

>T145068 WP_000802136.1 NZ_CP046841:383365-383664 [Vibrio cholerae]
MKPFNLTVAAKADLRDIALFTQRRWGKEQRNVYLKQFDDSFWLLAENPDIGKSCDEIREGYRKFPQGSHVIFYQQTGSQQ
IRVIRILHKSMDVNPIFGA

Download         Length: 300 bp

>T145068 NZ_CP062253:c1841602-1841099 [Pseudomonas gozinkensis]
ATGTGGCTTGCCCTCTCAGGACGATTTCGCGCGCGATGGACCCAGGAGATTCACTGCGAATGGAAACGCAATCTGCTGAA
GAACCGCCCTGACCTGACGATGGAACAGCTGGATCGTACGTCCGGCCTGATGGATCAAGCGATACCCGACGCCTGTGTCC
ATGACTATGAAGATCTGATCGCCGGACTCACCTTGCCCGACTGCGATGATCGTCATGTTCTGGCAGCGGCCATCCGCTGC
GGCGCAAGCGTGATAGTGACGTTCAACCAGAAAGACTTTCCCTGCAAAGCGCTGGAGCCTTTCGGCATCGAAGCGCAACA
TCCGGACGAGTTCGTCGACAACCTCTTGGGGCTTGATCCGGCAGCAGTGGTTGCAGCGGCCCAAAAGCAGCGTCGGCAGC
TGAAAATGCCTGCCATGGACGTCGAACCCTTTCTTGATCTACTGCAACGACAAGGCCTGATTAAATCGGCCCAGGCACTG
AGCGGCTATCACGCGATTCTTTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8964.84 Da        Isoelectric Point: 4.1677

>AT145068 WP_001107719.1 NZ_CP046841:383126-383368 [Vibrio cholerae]
MAKNTSITLGEHFDGFITSQIQSGRYGSASEVIRSALRLLENQETKLQSLRQLLIEGEQSGDADYDLDSFINELDSENIR

Download         Length: 243 bp

>AT145068 NZ_CP062253:c1842151-1841684 [Pseudomonas gozinkensis]
ATGTCGACCGTTATTCATCCCTCCATCAGCCTCCCCGTAGAACGCGAAGTAAAAGCCGCCATTGAAGGGCAGCGTGCCCT
GGCGGCTTACCTCGCGACCCATTTCGAGACTCAGCACATCCAGATTTTCGACGAACAGAACGAGGCTCATCGCGTCGAAC
TGCCCACCTCGGCCCTGCGCTTGCTGATCGACATTCTGGCTGAGCAGGCAGCCGGCAACGCGGTTCAGGTCGTCCCGGTG
CATGCCGAATTGACGACCCAGGAAGCCGCGGACCTGCTCAACGTCTCACGTCCACACCTCATAAAACTGCTGGAAAGCGG
CGAGTTGTCCTACCACAAAACAGGCAAGCACCGACGTGTGCGTTTTGCCGATCTGATGGACTATAAGACCCGGCGCACCA
CCGCCAGCGAGCAGGCAATGGCGCTTCTCGCAGAGCAAGCTCAGGCGTTAAGGACAGGATACGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
PDB7R5A

Antitoxin

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Source
ID
Structure
PDB7R5A
PDB7B22
AlphaFold DBA0A151JFU4

References