145072

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-Phd
Location 400098..400676 Replicon chromosome
Accession NZ_CP046841
Organism Vibrio cholerae strain F9993

Toxin (Protein)


Gene name parE Uniprot ID O68848
Locus tag GPY07_RS16490 Protein ID WP_001180243.1
Coordinates 400359..400676 (+) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q7DCR7
Locus tag GPY07_RS16485 Protein ID WP_000557292.1
Coordinates 400098..400340 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GPY07_RS16425 395492..395938 - 447 WP_000006157.1 hypothetical protein -
GPY07_RS16435 396134..396172 - 39 WP_106019118.1 hypothetical protein -
GPY07_RS16440 396188..396313 - 126 WP_001900195.1 DUF645 family protein -
GPY07_RS16445 396706..396978 + 273 WP_000246253.1 DUF1778 domain-containing protein -
GPY07_RS16450 396975..397472 + 498 WP_000982260.1 GNAT family N-acetyltransferase -
GPY07_RS16455 397622..398137 - 516 WP_001201509.1 lipocalin family protein -
GPY07_RS16460 398274..398810 - 537 WP_000469482.1 GNAT family N-acetyltransferase -
GPY07_RS16470 399068..399349 - 282 WP_001894429.1 DUF1289 domain-containing protein -
GPY07_RS16475 399298..399411 - 114 WP_001900214.1 hypothetical protein -
GPY07_RS16480 399468..399854 - 387 WP_001015867.1 NUDIX hydrolase -
GPY07_RS16485 400098..400340 + 243 WP_000557292.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
GPY07_RS16490 400359..400676 + 318 WP_001180243.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GPY07_RS16500 400830..401168 - 339 WP_000713853.1 hypothetical protein -
GPY07_RS16505 401326..402030 - 705 WP_000087610.1 HNH endonuclease -
GPY07_RS16510 402192..403400 - 1209 WP_000272282.1 deoxyguanosinetriphosphate triphosphohydrolase family protein -
GPY07_RS16515 403562..404239 - 678 WP_000254617.1 HNH endonuclease -
GPY07_RS16520 404434..404616 - 183 WP_000923153.1 DUF645 family protein -
GPY07_RS16525 404970..405152 - 183 WP_000923340.1 DUF645 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 322056..419024 96968
inside Integron - - 322432..412236 89804


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-93)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-71)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12158.97 Da        Isoelectric Point: 9.7495

>T145072 WP_001180243.1 NZ_CP046841:400359-400676 [Vibrio cholerae]
MQNKQYKLSQLAQEHLLKIKHYTIENFAEAQWQKYKSTLLSGFQTLADNPGLGKSCEDIYQNGFYFPVGKHMAYYTKEAN
FILIVAVLGQSQLPQKHLKQSRFVS

Download         Length: 318 bp

>T145072 NZ_CP062253:5368257-5368511 [Pseudomonas gozinkensis]
ATGGACACTATCAACTACACCACAGCTCGTGCGCACTTGGCTGAAACCATGGATCGCGTGAATGAAGACTGCGCCCCGCT
TCTGGTAACCCGCCAAAAAGGCGAGCCTGTAGTGATGATGTCTCTGGCCGAATACAACGCGCTGGAAGAAACGGCCTATC
TGCTGCGTTCTCCGGCCAATGCCGAGCGCTTGATCAAATCGATTGGCGAAATGCGCGCTGGAAAAGTCAAAGTCAGGCAA
CTGATTGAAGAATGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.25 Da        Isoelectric Point: 5.6630

>AT145072 WP_000557292.1 NZ_CP046841:400098-400340 [Vibrio cholerae]
MHTLTANDAKRNFGELLLSAQREPVIISKNSKNTVVVMSIKDFEELEAMKLDYLKHCFESAQKDLDSGKTVDGATFLNTL

Download         Length: 243 bp

>AT145072 NZ_CP062253:5368508-5368762 [Pseudomonas gozinkensis]
ATGAAAATCCAGTTCACGCCGACGGGCTGGGAAGACTACTTGTGGTTTCAGCAAAACGATAAGGCCGGTCTCAAACGAAT
CAATCTTTTGATCAAAGCGATCCAGCGCCAACCCTTTGAAGGCTTGGGTAAACCGGAGCCGCTCAAGCACAACATGAGCG
GCTTCTGGTCACGGCGGATAACTGCCGAGCATCGCCTGGTCTATGCAATCGTAGACGGCGAAATCTGCGTCATAACATGC
AGATTTCACTACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0K9UJR8

Antitoxin

Source ID Structure
AlphaFold DB Q7DCR7

References