Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-Phd
Location 400098..400676 Replicon chromosome
Accession NZ_CP046841
Organism Vibrio cholerae strain F9993

Toxin (Protein)


Gene name parE Uniprot ID O68848
Locus tag GPY07_RS16490 Protein ID WP_001180243.1
Coordinates 400359..400676 (+) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q7DCR7
Locus tag GPY07_RS16485 Protein ID WP_000557292.1
Coordinates 400098..400340 (+) Length 81 a.a.

Genomic Context

GPY07_RS16445GPY07_RS16450GPY07_RS16485GPY07_RS16490GPY07_RS16425GPY07_RS16435GPY07_RS16440GPY07_RS16455GPY07_RS16460GPY07_RS16470GPY07_RS16475GPY07_RS16480GPY07_RS16500GPY07_RS16505GPY07_RS16510GPY07_RS16515GPY07_RS16520GPY07_RS16525
Location: 396706..396978 (273 bp)
Type: Others
Protein ID: WP_000246253.1
Location: 396975..397472 (498 bp)
Type: Others
Protein ID: WP_000982260.1
Location: 400098..400340 (243 bp)
Type: Antitoxin
Protein ID: WP_000557292.1
Location: 400359..400676 (318 bp)
Type: Toxin
Protein ID: WP_001180243.1
Location: 395492..395938 (447 bp)
Type: Others
Protein ID: WP_000006157.1
Location: 396134..396172 (39 bp)
Type: Others
Protein ID: WP_106019118.1
Location: 396188..396313 (126 bp)
Type: Others
Protein ID: WP_001900195.1
Location: 397622..398137 (516 bp)
Type: Others
Protein ID: WP_001201509.1
Location: 398274..398810 (537 bp)
Type: Others
Protein ID: WP_000469482.1
Location: 399068..399349 (282 bp)
Type: Others
Protein ID: WP_001894429.1
Location: 399298..399411 (114 bp)
Type: Others
Protein ID: WP_001900214.1
Location: 399468..399854 (387 bp)
Type: Others
Protein ID: WP_001015867.1
Location: 400830..401168 (339 bp)
Type: Others
Protein ID: WP_000713853.1
Location: 401326..402030 (705 bp)
Type: Others
Protein ID: WP_000087610.1
Location: 402192..403400 (1209 bp)
Type: Others
Protein ID: WP_000272282.1
Location: 403562..404239 (678 bp)
Type: Others
Protein ID: WP_000254617.1
Location: 404434..404616 (183 bp)
Type: Others
Protein ID: WP_000923153.1
Location: 404970..405152 (183 bp)
Type: Others
Protein ID: WP_000923340.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
GPY07_RS16425395492..395938-447WP_000006157.1hypothetical protein-
GPY07_RS16435396134..396172-39WP_106019118.1hypothetical protein-
GPY07_RS16440396188..396313-126WP_001900195.1DUF645 family protein-
GPY07_RS16445396706..396978+273WP_000246253.1DUF1778 domain-containing protein-
GPY07_RS16450396975..397472+498WP_000982260.1GNAT family N-acetyltransferase-
GPY07_RS16455397622..398137-516WP_001201509.1lipocalin family protein-
GPY07_RS16460398274..398810-537WP_000469482.1GNAT family N-acetyltransferase-
GPY07_RS16470399068..399349-282WP_001894429.1DUF1289 domain-containing protein-
GPY07_RS16475399298..399411-114WP_001900214.1hypothetical protein-
GPY07_RS16480399468..399854-387WP_001015867.1NUDIX hydrolase-
GPY07_RS16485400098..400340+243WP_000557292.1type II toxin-antitoxin system Phd/YefM family antitoxinAntitoxin
GPY07_RS16490400359..400676+318WP_001180243.1type II toxin-antitoxin system RelE/ParE family toxinToxin
GPY07_RS16500400830..401168-339WP_000713853.1hypothetical protein-
GPY07_RS16505401326..402030-705WP_000087610.1HNH endonuclease-
GPY07_RS16510402192..403400-1209WP_000272282.1deoxyguanosinetriphosphate triphosphohydrolase family protein-
GPY07_RS16515403562..404239-678WP_000254617.1HNH endonuclease-
GPY07_RS16520404434..404616-183WP_000923153.1DUF645 family protein-
GPY07_RS16525404970..405152-183WP_000923340.1DUF645 family protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-322056..41902496968
insideIntegron--322432..41223689804


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-93)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-71)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12158.97 Da        Isoelectric Point: 9.7495

>T145072 WP_001180243.1 NZ_CP046841:400359-400676 [Vibrio cholerae]
MQNKQYKLSQLAQEHLLKIKHYTIENFAEAQWQKYKSTLLSGFQTLADNPGLGKSCEDIYQNGFYFPVGKHMAYYTKEAN
FILIVAVLGQSQLPQKHLKQSRFVS

Download         Length: 318 bp

>T145072 NZ_CP062253:5368257-5368511 [Pseudomonas gozinkensis]
ATGGACACTATCAACTACACCACAGCTCGTGCGCACTTGGCTGAAACCATGGATCGCGTGAATGAAGACTGCGCCCCGCT
TCTGGTAACCCGCCAAAAAGGCGAGCCTGTAGTGATGATGTCTCTGGCCGAATACAACGCGCTGGAAGAAACGGCCTATC
TGCTGCGTTCTCCGGCCAATGCCGAGCGCTTGATCAAATCGATTGGCGAAATGCGCGCTGGAAAAGTCAAAGTCAGGCAA
CTGATTGAAGAATGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.25 Da        Isoelectric Point: 5.6630

>AT145072 WP_000557292.1 NZ_CP046841:400098-400340 [Vibrio cholerae]
MHTLTANDAKRNFGELLLSAQREPVIISKNSKNTVVVMSIKDFEELEAMKLDYLKHCFESAQKDLDSGKTVDGATFLNTL

Download         Length: 243 bp

>AT145072 NZ_CP062253:5368508-5368762 [Pseudomonas gozinkensis]
ATGAAAATCCAGTTCACGCCGACGGGCTGGGAAGACTACTTGTGGTTTCAGCAAAACGATAAGGCCGGTCTCAAACGAAT
CAATCTTTTGATCAAAGCGATCCAGCGCCAACCCTTTGAAGGCTTGGGTAAACCGGAGCCGCTCAAGCACAACATGAGCG
GCTTCTGGTCACGGCGGATAACTGCCGAGCATCGCCTGGTCTATGCAATCGTAGACGGCGAAATCTGCGTCATAACATGC
AGATTTCACTACTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0K9UJR8

Antitoxin

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Source
ID
Structure
AlphaFold DBQ7DCR7

References