Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /BrnT(toxin)
Location 964384..964882 Replicon chromosome
Accession NZ_LT992487
Organism Vibrio cholerae strain 4295STDY6534216

Toxin (Protein)


Gene name - Uniprot ID Q9KMK7
Locus tag DG247_RS19020 Protein ID WP_000589156.1
Coordinates 964616..964882 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q9KMK6
Locus tag DG247_RS19015 Protein ID WP_000643598.1
Coordinates 964384..964629 (-) Length 82 a.a.

Genomic Context

DG247_RS18955DG247_RS18970DG247_RS18975DG247_RS18980DG247_RS18985DG247_RS18990DG247_RS18995DG247_RS19840DG247_RS19010DG247_RS19015DG247_RS19020DG247_RS19030DG247_RS19035DG247_RS19845DG247_RS19850DG247_RS19055DG247_RS19060DG247_RS19065DG247_RS19070DG247_RS19075DG247_RS19080DG247_RS19085
Location: 959874..960053 (180 bp)
Type: Others
Protein ID: WP_001883058.1
Location: 960631..960741 (111 bp)
Type: Others
Protein ID: WP_079857360.1
Location: 960751..961449 (699 bp)
Type: Others
Protein ID: WP_001890502.1
Location: 961572..962198 (627 bp)
Type: Others
Protein ID: WP_000365424.1
Location: 962240..962332 (93 bp)
Type: Others
Protein ID: WP_014378730.1
Location: 962347..962820 (474 bp)
Type: Others
Protein ID: WP_001161076.1
Location: 963020..963202 (183 bp)
Type: Others
Protein ID: WP_000923182.1
Location: 963263..963391 (129 bp)
Type: Others
Protein ID: WP_071908338.1
Location: 963494..964288 (795 bp)
Type: Others
Protein ID: WP_001911581.1
Location: 964384..964629 (246 bp)
Type: Antitoxin
Protein ID: WP_000643598.1
Location: 964616..964882 (267 bp)
Type: Toxin
Protein ID: WP_000589156.1
Location: 965067..965729 (663 bp)
Type: Others
Protein ID: WP_000960654.1
Location: 965857..966324 (468 bp)
Type: Others
Protein ID: WP_001289288.1
Location: 966536..966574 (39 bp)
Type: Others
Protein ID: WP_082798268.1
Location: 966628..966771 (144 bp)
Type: Others
Protein ID: Protein_877
Location: 967146..967424 (279 bp)
Type: Others
Protein ID: WP_000280324.1
Location: 967676..967918 (243 bp)
Type: Others
Protein ID: WP_000107461.1
Location: 968010..968159 (150 bp)
Type: Others
Protein ID: WP_071908333.1
Location: 968132..968383 (252 bp)
Type: Others
Protein ID: WP_001890111.1
Location: 968578..968964 (387 bp)
Type: Others
Protein ID: WP_000703163.1
Location: 968954..969055 (102 bp)
Type: Others
Protein ID: WP_001921603.1
Location: 969255..969461 (207 bp)
Type: Others
Protein ID: Protein_884
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
DG247_RS18955959874..960053-180WP_001883058.1DUF645 family protein-
DG247_RS18970960631..960741-111WP_079857360.1DUF3265 domain-containing protein-
DG247_RS18975960751..961449-699WP_001890502.1hypothetical protein-
DG247_RS18980961572..962198-627WP_000365424.1LysE family translocator-
DG247_RS18985962240..962332-93WP_014378730.1DUF3265 domain-containing protein-
DG247_RS18990962347..962820-474WP_001161076.1GrpB family protein-
DG247_RS18995963020..963202-183WP_000923182.1DUF645 family protein-
DG247_RS19840963263..963391-129WP_071908338.1general secretion pathway protein GspI-
DG247_RS19010963494..964288-795WP_001911581.1hypothetical protein-
DG247_RS19015964384..964629-246WP_000643598.1hypothetical proteinAntitoxin
DG247_RS19020964616..964882-267WP_000589156.1BrnT family toxinToxin
DG247_RS19030965067..965729-663WP_000960654.1hypothetical protein-
DG247_RS19035965857..966324-468WP_001289288.1OsmC family protein-
DG247_RS19845966536..966574-39WP_082798268.1hypothetical protein-
DG247_RS19850966628..966771-144Protein_877DUF645 family protein-
DG247_RS19055967146..967424-279WP_000280324.1DUF3709 domain-containing protein-
DG247_RS19060967676..967918-243WP_000107461.1hypothetical protein-
DG247_RS19065968010..968159-150WP_071908333.1DUF3265 domain-containing protein-
DG247_RS19070968132..968383-252WP_001890111.1TIGR03643 family protein-
DG247_RS19075968578..968964-387WP_000703163.1VOC family protein-
DG247_RS19080968954..969055-102WP_001921603.1hypothetical protein-
DG247_RS19085969255..969461-207Protein_884DUF3709 domain-containing protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-897525..99449796972
insideIntegroncatB9-897901..98770989808


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(6-81)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10092.34 Da        Isoelectric Point: 7.3171

>T294361 WP_000589156.1 NZ_LT992487:c964882-964616 [Vibrio cholerae]
MIKFEFDENKSRSNLEKHGIDFHTAQGLWNDSDLIEIPANTSDEPRYLVVGLLNGKHWSGVITYRGTNIRIISVRRSRKA
EVSLYESA

Download         Length: 267 bp

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9478.77 Da        Isoelectric Point: 6.4832

>AT294361 WP_000643598.1 NZ_LT992487:c964629-964384 [Vibrio cholerae]
MKAHEFDAKFESDDDDIVMDLDLSQAKRPMHKQKRVNVDFPAWMLESLDREASRIGVTRQSIIKIWLAERLESVSHHSSV
R

Download         Length: 246 bp


Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A271VMP7

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A271VME2

References