Detailed information of TA system TA058391

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): DhiAT/-
• Location: 353385..354169
• Replicon: chromosome
• Accession: NZ_CP013318
• Organism: Vibrio cholerae strain NCTC5395

Toxin (Protein)

• Gene name: dhiT
• Uniprot ID: A0A086SLD6
• Locus tag: ASZ85_RS15800
• Protein ID: WP_001114075.1
• Coordinates: 353385..353654 (+)
• Length: 90 a.a.

Antitoxin (Protein)

• Gene name: dhiA
• Uniprot ID: C3LUY7
• Locus tag: ASZ85_RS15805
• Protein ID: WP_000921692.1
• Coordinates: 353648..354169 (+)
• Length: 174 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ASZ85_RS15755	348684..349379	+	696	WP_001900183.1	hypothetical protein	-
ASZ85_RS15760	349499..349936	+	438	WP_173664326.1	hypothetical protein	-
ASZ85_RS15765	349914..350063	+	150	WP_001900216.1	DUF3265 domain-containing protein	-
ASZ85_RS20910	350682..350861	+	180	Protein_310	DUF645 family protein	-
ASZ85_RS15780	351079..351507	+	429	WP_000620002.1	N-acetyltransferase	-
ASZ85_RS15790	352095..352577	+	483	WP_000422940.1	GNAT family N-acetyltransferase	-
ASZ85_RS15800	353385..353654	+	270	WP_001114075.1	DUF4160 domain-containing protein	Toxin
ASZ85_RS15805	353648..354169	+	522	WP_000921692.1	DUF2442 domain-containing protein	Antitoxin
ASZ85_RS20925	354226..354339	+	114	WP_001894981.1	hypothetical protein	-
ASZ85_RS15810	354308..355144	+	837	WP_000242986.1	hypothetical protein	-
ASZ85_RS15815	355309..355947	+	639	WP_000230118.1	HD domain-containing protein	-
ASZ85_RS20930	356037..356197	+	161	Protein_318	DUF3709 domain-containing protein	-
ASZ85_RS15820	356218..356439	+	222	WP_012705854.1	DUF3709 domain-containing protein	-
ASZ85_RS15830	356759..357079	+	321	WP_001909340.1	DUF1778 domain-containing protein	-
ASZ85_RS15835	357076..357609	+	534	WP_000118351.1	GNAT family N-acetyltransferase	-
ASZ85_RS15840	357847..358125	+	279	WP_000280324.1	DUF3709 domain-containing protein	-
ASZ85_RS15845	358526..358750	+	225	WP_001894423.1	DUF3709 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	338285..496833	158548
	Similar MGE(s) Similar MGE(s) is defined as other TA-related MGE(s) with Mash distance < 0.01 to this MGE. Detail Genome accession Organism MGE type Related TA Coordinates Mash distance View NC_002506 Vibrio cholerae O1 biovar El Tor str. N16961 Integron TA000164, TA000169, TA000166, TA000167, TA000179, TA000170, TA000171, TA000172, TA000173, TA000174, TA000175, TA000176, TA000177, TA000178, TA000168, TA000165, TA010030, TA010035 309750..435387 0.009	inside	Integron	-	-	343365..496457	153092

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF4160 (9-74)

Antitoxin

• Protein of unknown function DUF2442 (4-59)

Sequences

Toxin

Protein

• Length: 90 a.a.
• Molecular weight: 10310.94 Da
• Isoelectric Point: 6.6303

>T58391 WP_001114075.1 NZ_CP013318:353385-353654 [Vibrio cholerae]
MPEIDALLGLSFCLYFFDNKQHKLPHIHVKYGSYELIIAIETGECLEGYLPNKQRKRAENHILEHREQLMVMWNKAVNGE
NPGKLGDLC

Nucleotide

• Length: 270 bp

>T58391 NZ_CP013318:353385-353654 [Vibrio cholerae]
ATGCCAGAGATTGATGCCCTATTAGGCCTTTCATTTTGCTTGTACTTCTTTGATAACAAGCAGCATAAATTGCCTCATAT
TCACGTTAAGTACGGTAGTTACGAGCTAATTATTGCTATTGAAACAGGTGAGTGTTTAGAGGGTTACTTACCCAATAAAC
AACGAAAACGTGCTGAAAACCATATTCTTGAACATCGAGAGCAATTGATGGTGATGTGGAATAAAGCGGTGAATGGTGAA
AATCCAGGTAAGTTAGGTGATTTATGTTGA

Antitoxin

Protein

• Length: 174 a.a.
• Molecular weight: 19439.04 Da
• Isoelectric Point: 6.7342

>AT58391 WP_000921692.1 NZ_CP013318:353648-354169 [Vibrio cholerae]
MLKVIDVDFVSDHTLELTFNDGYQGYADLSVYFKKTPFSEIKDFKRFSLTRDGSLNWDGNELTAATLRDITKGSQKSVEL
SFNVQEMEAVIKQASWESMMEGRPDILQAAIRSYVEQFGHGQVIAKAGIKSRTSAYRSLKPETTPNFGTLVQLGHAVIEL
AKDRTVANKEPRI

Nucleotide

• Length: 522 bp

>AT58391 NZ_CP013318:353648-354169 [Vibrio cholerae]
ATGTTGAAAGTCATAGATGTTGATTTTGTCTCAGACCATACATTAGAACTGACGTTCAATGATGGTTACCAAGGCTATGC
CGACTTGTCGGTATACTTTAAAAAAACACCGTTTTCAGAAATTAAGGACTTTAAACGCTTTTCCTTGACTCGTGATGGCT
CGTTAAATTGGGATGGTAATGAGTTAACGGCCGCGACACTCCGTGACATAACCAAGGGCTCACAAAAGTCGGTGGAGTTA
AGTTTTAATGTTCAAGAAATGGAAGCCGTCATCAAACAGGCCTCATGGGAATCGATGATGGAGGGGCGTCCCGACATCTT
GCAAGCGGCTATTCGTTCTTACGTAGAGCAGTTTGGTCATGGTCAAGTTATTGCAAAGGCGGGTATAAAAAGTCGTACGA
GTGCTTATCGCTCCTTGAAGCCAGAAACAACGCCAAACTTTGGCACACTAGTTCAGTTAGGGCACGCCGTCATCGAACTA
GCGAAAGATAGAACAGTGGCAAACAAGGAACCACGCATATAA

Structures

Toxin

• AlphaFold DB: A0A086SLD6

Antitoxin

• AlphaFold DB: C3LUY7