Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DhiAT/-
Location 353385..354169 Replicon chromosome
Accession NZ_CP013318
Organism Vibrio cholerae strain NCTC5395

Toxin (Protein)


Gene name dhiT Uniprot ID A0A086SLD6
Locus tag ASZ85_RS15800 Protein ID WP_001114075.1
Coordinates 353385..353654 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name dhiA Uniprot ID C3LUY7
Locus tag ASZ85_RS15805 Protein ID WP_000921692.1
Coordinates 353648..354169 (+) Length 174 a.a.

Genomic Context

ASZ85_RS15755ASZ85_RS15760ASZ85_RS15765ASZ85_RS20910ASZ85_RS15780ASZ85_RS15790ASZ85_RS15800ASZ85_RS15805ASZ85_RS20925ASZ85_RS15810ASZ85_RS15815ASZ85_RS20930ASZ85_RS15820ASZ85_RS15830ASZ85_RS15835ASZ85_RS15840ASZ85_RS15845
Location: 348684..349379 (696 bp)
Type: Others
Protein ID: WP_001900183.1
Location: 349499..349936 (438 bp)
Type: Others
Protein ID: WP_173664326.1
Location: 349914..350063 (150 bp)
Type: Others
Protein ID: WP_001900216.1
Location: 350682..350861 (180 bp)
Type: Others
Protein ID: Protein_310
Location: 351079..351507 (429 bp)
Type: Others
Protein ID: WP_000620002.1
Location: 352095..352577 (483 bp)
Type: Others
Protein ID: WP_000422940.1
Location: 353385..353654 (270 bp)
Type: Toxin
Protein ID: WP_001114075.1
Location: 353648..354169 (522 bp)
Type: Antitoxin
Protein ID: WP_000921692.1
Location: 354226..354339 (114 bp)
Type: Others
Protein ID: WP_001894981.1
Location: 354308..355144 (837 bp)
Type: Others
Protein ID: WP_000242986.1
Location: 355309..355947 (639 bp)
Type: Others
Protein ID: WP_000230118.1
Location: 356037..356197 (161 bp)
Type: Others
Protein ID: Protein_318
Location: 356218..356439 (222 bp)
Type: Others
Protein ID: WP_012705854.1
Location: 356759..357079 (321 bp)
Type: Others
Protein ID: WP_001909340.1
Location: 357076..357609 (534 bp)
Type: Others
Protein ID: WP_000118351.1
Location: 357847..358125 (279 bp)
Type: Others
Protein ID: WP_000280324.1
Location: 358526..358750 (225 bp)
Type: Others
Protein ID: WP_001894423.1
ToxinAntitoxinOther genes
Loading, please wait
Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
ASZ85_RS15755348684..349379+696WP_001900183.1hypothetical protein-
ASZ85_RS15760349499..349936+438WP_173664326.1hypothetical protein-
ASZ85_RS15765349914..350063+150WP_001900216.1DUF3265 domain-containing protein-
ASZ85_RS20910350682..350861+180Protein_310DUF645 family protein-
ASZ85_RS15780351079..351507+429WP_000620002.1N-acetyltransferase-
ASZ85_RS15790352095..352577+483WP_000422940.1GNAT family N-acetyltransferase-
ASZ85_RS15800353385..353654+270WP_001114075.1DUF4160 domain-containing proteinToxin
ASZ85_RS15805353648..354169+522WP_000921692.1DUF2442 domain-containing proteinAntitoxin
ASZ85_RS20925354226..354339+114WP_001894981.1hypothetical protein-
ASZ85_RS15810354308..355144+837WP_000242986.1hypothetical protein-
ASZ85_RS15815355309..355947+639WP_000230118.1HD domain-containing protein-
ASZ85_RS20930356037..356197+161Protein_318DUF3709 domain-containing protein-
ASZ85_RS15820356218..356439+222WP_012705854.1DUF3709 domain-containing protein-
ASZ85_RS15830356759..357079+321WP_001909340.1DUF1778 domain-containing protein-
ASZ85_RS15835357076..357609+534WP_000118351.1GNAT family N-acetyltransferase-
ASZ85_RS15840357847..358125+279WP_000280324.1DUF3709 domain-containing protein-
ASZ85_RS15845358526..358750+225WP_001894423.1DUF3709 domain-containing protein-

Associated MGEs

Loading, please wait
MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic island--338285..496833158548
insideIntegron--343365..496457153092


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF4160

(9-74)

Antitoxin

Protein of unknown function DUF2442

(4-59)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10310.94 Da        Isoelectric Point: 6.6303

>T58391 WP_001114075.1 NZ_CP013318:353385-353654 [Vibrio cholerae]
MPEIDALLGLSFCLYFFDNKQHKLPHIHVKYGSYELIIAIETGECLEGYLPNKQRKRAENHILEHREQLMVMWNKAVNGE
NPGKLGDLC

Download         Length: 270 bp

>T58391 NZ_CP013318:353385-353654 [Vibrio cholerae]
ATGCCAGAGATTGATGCCCTATTAGGCCTTTCATTTTGCTTGTACTTCTTTGATAACAAGCAGCATAAATTGCCTCATAT
TCACGTTAAGTACGGTAGTTACGAGCTAATTATTGCTATTGAAACAGGTGAGTGTTTAGAGGGTTACTTACCCAATAAAC
AACGAAAACGTGCTGAAAACCATATTCTTGAACATCGAGAGCAATTGATGGTGATGTGGAATAAAGCGGTGAATGGTGAA
AATCCAGGTAAGTTAGGTGATTTATGTTGA

Antitoxin


Download         Length: 174 a.a.        Molecular weight: 19439.04 Da        Isoelectric Point: 6.7342

>AT58391 WP_000921692.1 NZ_CP013318:353648-354169 [Vibrio cholerae]
MLKVIDVDFVSDHTLELTFNDGYQGYADLSVYFKKTPFSEIKDFKRFSLTRDGSLNWDGNELTAATLRDITKGSQKSVEL
SFNVQEMEAVIKQASWESMMEGRPDILQAAIRSYVEQFGHGQVIAKAGIKSRTSAYRSLKPETTPNFGTLVQLGHAVIEL
AKDRTVANKEPRI

Download         Length: 522 bp

>AT58391 NZ_CP013318:353648-354169 [Vibrio cholerae]
ATGTTGAAAGTCATAGATGTTGATTTTGTCTCAGACCATACATTAGAACTGACGTTCAATGATGGTTACCAAGGCTATGC
CGACTTGTCGGTATACTTTAAAAAAACACCGTTTTCAGAAATTAAGGACTTTAAACGCTTTTCCTTGACTCGTGATGGCT
CGTTAAATTGGGATGGTAATGAGTTAACGGCCGCGACACTCCGTGACATAACCAAGGGCTCACAAAAGTCGGTGGAGTTA
AGTTTTAATGTTCAAGAAATGGAAGCCGTCATCAAACAGGCCTCATGGGAATCGATGATGGAGGGGCGTCCCGACATCTT
GCAAGCGGCTATTCGTTCTTACGTAGAGCAGTTTGGTCATGGTCAAGTTATTGCAAAGGCGGGTATAAAAAGTCGTACGA
GTGCTTATCGCTCCTTGAAGCCAGAAACAACGCCAAACTTTGGCACACTAGTTCAGTTAGGGCACGCCGTCATCGAACTA
GCGAAAGATAGAACAGTGGCAAACAAGGAACCACGCATATAA

Similar Proteins

Only experimentally validated proteins are listed.

Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

Loading, please wait
Source
ID
Structure
AlphaFold DBA0A086SLD6

Antitoxin

Loading, please wait
Source
ID
Structure
AlphaFold DBC3LUY7

References