58314

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 560191..560719 Replicon chromosome
Accession NZ_CP013310
Organism Vibrio cholerae strain E1162

Toxin (Protein)


Gene name relE Uniprot ID H9L4R3
Locus tag ASZ87_RS17460 Protein ID WP_000221352.1
Coordinates 560191..560481 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID H9L4T4
Locus tag ASZ87_RS17465 Protein ID WP_000213183.1
Coordinates 560471..560719 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ASZ87_RS21110 555748..555873 + 126 WP_001944767.1 DUF645 family protein -
ASZ87_RS21115 555889..555927 + 39 WP_106019119.1 hypothetical protein -
ASZ87_RS17430 556140..557144 + 1005 WP_000964925.1 LD-carboxypeptidase -
ASZ87_RS17435 557297..557743 + 447 WP_000128977.1 hypothetical protein -
ASZ87_RS17440 557863..558792 + 930 WP_000335802.1 hypothetical protein -
ASZ87_RS20780 558789..558899 + 111 WP_071917832.1 DUF3265 domain-containing protein -
ASZ87_RS17450 558927..559403 + 477 WP_001047180.1 GNAT family N-acetyltransferase -
ASZ87_RS17455 559540..560055 + 516 WP_001201528.1 lipocalin family protein -
ASZ87_RS17460 560191..560481 - 291 WP_000221352.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ASZ87_RS17465 560471..560719 - 249 WP_000213183.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
ASZ87_RS17475 561290..561943 + 654 WP_000036957.1 site-specific DNA-methyltransferase -
ASZ87_RS17480 562215..562640 + 426 WP_000415748.1 hypothetical protein -
ASZ87_RS17485 562848..563243 + 396 WP_000649527.1 DUF3465 domain-containing protein -
ASZ87_RS17490 563394..563924 + 531 WP_000415563.1 hypothetical protein -
ASZ87_RS17495 564062..564562 + 501 WP_000789723.1 hypothetical protein -
ASZ87_RS17500 564718..565116 + 399 WP_001882293.1 hypothetical protein -
ASZ87_RS17505 565216..565680 - 465 WP_000140244.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 435534..596659 161125
inside Integron - - 440614..596283 155669


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11247.23 Da        Isoelectric Point: 10.4678

>T58314 WP_000221352.1 NZ_CP013310:c560481-560191 [Vibrio cholerae]
MTYKLEFKKSALKEWKKLAVPLQQQFKKKLIERLENPHVPSAKLSGAENIYKIKLRQSGYRLVYQVENDIIVVTVLAVGK
RERSEVYTKALQRLDD

Download         Length: 291 bp

>T58314 NZ_CP013310:c560481-560191 [Vibrio cholerae]
ATGACCTATAAGCTTGAGTTCAAAAAGAGTGCTTTGAAGGAATGGAAAAAGTTAGCCGTTCCACTCCAACAGCAGTTCAA
GAAGAAACTAATAGAACGCCTTGAAAATCCACATGTTCCATCAGCCAAACTGTCTGGCGCTGAGAACATTTATAAAATAA
AACTTCGGCAGTCTGGTTATCGCTTAGTCTATCAAGTTGAAAATGACATCATCGTAGTTACTGTTTTAGCTGTCGGTAAA
CGAGAACGCAGCGAAGTTTACACTAAAGCGCTGCAACGGCTAGACGACTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8937.28 Da        Isoelectric Point: 4.1079

>AT58314 WP_000213183.1 NZ_CP013310:c560719-560471 [Vibrio cholerae]
MTTRILADVAASITEFKANPMKVATSAFGAPVAVLNRNEPAFYCVPASTYEIMMDKLEDLELLAIAKERLSEDSVSVNID
DL

Download         Length: 249 bp

>AT58314 NZ_CP013310:c560719-560471 [Vibrio cholerae]
ATGACCACTAGAATCCTAGCTGATGTTGCAGCAAGCATTACCGAATTTAAAGCAAACCCAATGAAAGTTGCAACTAGTGC
CTTCGGTGCTCCTGTTGCTGTACTCAACCGAAATGAGCCGGCTTTCTACTGCGTCCCTGCAAGCACCTACGAGATCATGA
TGGATAAGCTTGAAGATCTTGAGCTACTGGCTATTGCCAAAGAACGCTTAAGTGAAGACAGCGTATCGGTAAATATCGAT
GACCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB H9L4R3

Antitoxin

Source ID Structure
AlphaFold DB A0A366A3W8

References