Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 560191..560719 Replicon chromosome
Accession NZ_CP013310
Organism Vibrio cholerae strain E1162

Toxin (Protein)


Gene name relE Uniprot ID H9L4R3
Locus tag ASZ87_RS17460 Protein ID WP_000221352.1
Coordinates 560191..560481 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID H9L4T4
Locus tag ASZ87_RS17465 Protein ID WP_000213183.1
Coordinates 560471..560719 (-) Length 83 a.a.

Genomic Context

ASZ87_RS21110ASZ87_RS21115ASZ87_RS17430ASZ87_RS17435ASZ87_RS17440ASZ87_RS20780ASZ87_RS17450ASZ87_RS17455ASZ87_RS17475ASZ87_RS17480ASZ87_RS17485ASZ87_RS17490ASZ87_RS17495ASZ87_RS17500ASZ87_RS17460ASZ87_RS17465ASZ87_RS17505
Location: 555748..555873 (126 bp)
Type: Others
Protein ID: WP_001944767.1
Location: 555889..555927 (39 bp)
Type: Others
Protein ID: WP_106019119.1
Location: 556140..557144 (1005 bp)
Type: Others
Protein ID: WP_000964925.1
Location: 557297..557743 (447 bp)
Type: Others
Protein ID: WP_000128977.1
Location: 557863..558792 (930 bp)
Type: Others
Protein ID: WP_000335802.1
Location: 558789..558899 (111 bp)
Type: Others
Protein ID: WP_071917832.1
Location: 558927..559403 (477 bp)
Type: Others
Protein ID: WP_001047180.1
Location: 559540..560055 (516 bp)
Type: Others
Protein ID: WP_001201528.1
Location: 561290..561943 (654 bp)
Type: Others
Protein ID: WP_000036957.1
Location: 562215..562640 (426 bp)
Type: Others
Protein ID: WP_000415748.1
Location: 562848..563243 (396 bp)
Type: Others
Protein ID: WP_000649527.1
Location: 563394..563924 (531 bp)
Type: Others
Protein ID: WP_000415563.1
Location: 564062..564562 (501 bp)
Type: Others
Protein ID: WP_000789723.1
Location: 564718..565116 (399 bp)
Type: Others
Protein ID: WP_001882293.1
Location: 560191..560481 (291 bp)
Type: Toxin
Protein ID: WP_000221352.1
Location: 560471..560719 (249 bp)
Type: Antitoxin
Protein ID: WP_000213183.1
Location: 565216..565680 (465 bp)
Type: Others
Protein ID: WP_000140244.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
ASZ87_RS21110555748..555873+126WP_001944767.1DUF645 family protein-
ASZ87_RS21115555889..555927+39WP_106019119.1hypothetical protein-
ASZ87_RS17430556140..557144+1005WP_000964925.1LD-carboxypeptidase-
ASZ87_RS17435557297..557743+447WP_000128977.1hypothetical protein-
ASZ87_RS17440557863..558792+930WP_000335802.1hypothetical protein-
ASZ87_RS20780558789..558899+111WP_071917832.1DUF3265 domain-containing protein-
ASZ87_RS17450558927..559403+477WP_001047180.1GNAT family N-acetyltransferase-
ASZ87_RS17455559540..560055+516WP_001201528.1lipocalin family protein-
ASZ87_RS17460560191..560481-291WP_000221352.1type II toxin-antitoxin system RelE/ParE family toxinToxin
ASZ87_RS17465560471..560719-249WP_000213183.1type II toxin-antitoxin system Phd/YefM family antitoxinAntitoxin
ASZ87_RS17475561290..561943+654WP_000036957.1site-specific DNA-methyltransferase-
ASZ87_RS17480562215..562640+426WP_000415748.1hypothetical protein-
ASZ87_RS17485562848..563243+396WP_000649527.1DUF3465 domain-containing protein-
ASZ87_RS17490563394..563924+531WP_000415563.1hypothetical protein-
ASZ87_RS17495564062..564562+501WP_000789723.1hypothetical protein-
ASZ87_RS17500564718..565116+399WP_001882293.1hypothetical protein-
ASZ87_RS17505565216..565680-465WP_000140244.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-435534..596659161125
insideIntegron--440614..596283155669


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11247.23 Da        Isoelectric Point: 10.4678

>T58314 WP_000221352.1 NZ_CP013310:c560481-560191 [Vibrio cholerae]
MTYKLEFKKSALKEWKKLAVPLQQQFKKKLIERLENPHVPSAKLSGAENIYKIKLRQSGYRLVYQVENDIIVVTVLAVGK
RERSEVYTKALQRLDD

Download         Length: 291 bp

>T58314 NZ_CP013310:c560481-560191 [Vibrio cholerae]
ATGACCTATAAGCTTGAGTTCAAAAAGAGTGCTTTGAAGGAATGGAAAAAGTTAGCCGTTCCACTCCAACAGCAGTTCAA
GAAGAAACTAATAGAACGCCTTGAAAATCCACATGTTCCATCAGCCAAACTGTCTGGCGCTGAGAACATTTATAAAATAA
AACTTCGGCAGTCTGGTTATCGCTTAGTCTATCAAGTTGAAAATGACATCATCGTAGTTACTGTTTTAGCTGTCGGTAAA
CGAGAACGCAGCGAAGTTTACACTAAAGCGCTGCAACGGCTAGACGACTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8937.28 Da        Isoelectric Point: 4.1079

>AT58314 WP_000213183.1 NZ_CP013310:c560719-560471 [Vibrio cholerae]
MTTRILADVAASITEFKANPMKVATSAFGAPVAVLNRNEPAFYCVPASTYEIMMDKLEDLELLAIAKERLSEDSVSVNID
DL

Download         Length: 249 bp

>AT58314 NZ_CP013310:c560719-560471 [Vibrio cholerae]
ATGACCACTAGAATCCTAGCTGATGTTGCAGCAAGCATTACCGAATTTAAAGCAAACCCAATGAAAGTTGCAACTAGTGC
CTTCGGTGCTCCTGTTGCTGTACTCAACCGAAATGAGCCGGCTTTCTACTGCGTCCCTGCAAGCACCTACGAGATCATGA
TGGATAAGCTTGAAGATCTTGAGCTACTGGCTATTGCCAAAGAACGCTTAAGTGAAGACAGCGTATCGGTAAATATCGAT
GACCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBH9L4R3

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A366A3W8

References