Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | parDE/ParE-Phd |
| Location | 326212..326790 | Replicon | chromosome |
| Accession | NZ_CP047300 | ||
| Organism | Vibrio cholerae O1 biovar El Tor strain P27459 | ||
Toxin (Protein)
| Gene name | parE | Uniprot ID | O68848 |
| Locus tag | GTF71_RS14855 | Protein ID | WP_001180243.1 |
| Coordinates | 326212..326529 (-) | Length | 106 a.a. |
Antitoxin (Protein)
| Gene name | parD | Uniprot ID | Q7DCR7 |
| Locus tag | GTF71_RS14860 | Protein ID | WP_000557292.1 |
| Coordinates | 326548..326790 (-) | Length | 81 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| GTF71_RS14830 | 321379..322056 | + | 678 | WP_000254617.1 | HNH endonuclease | - |
| GTF71_RS14835 | 322218..323381 | + | 1164 | WP_170966080.1 | deoxyguanosinetriphosphate triphosphohydrolase family protein | - |
| GTF71_RS14840 | 323449..324635 | + | 1187 | WP_156991674.1 | IS3-like element ISVch4 family transposase | - |
| GTF71_RS14845 | 324858..325562 | + | 705 | WP_000087610.1 | HNH endonuclease | - |
| GTF71_RS14850 | 325720..326058 | + | 339 | WP_000713853.1 | hypothetical protein | - |
| GTF71_RS14855 | 326212..326529 | - | 318 | WP_001180243.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| GTF71_RS14860 | 326548..326790 | - | 243 | WP_000557292.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| GTF71_RS14865 | 327034..327420 | + | 387 | WP_001015867.1 | NUDIX hydrolase | - |
| GTF71_RS14870 | 327477..327590 | + | 114 | WP_001900214.1 | hypothetical protein | - |
| GTF71_RS14875 | 327539..327820 | + | 282 | WP_001894429.1 | DUF1289 domain-containing protein | - |
| GTF71_RS14880 | 327796..327954 | - | 159 | WP_001886450.1 | DUF1196 family protein | - |
| GTF71_RS14885 | 328078..328614 | + | 537 | WP_000469482.1 | GNAT family N-acetyltransferase | - |
| GTF71_RS14890 | 328751..329266 | + | 516 | WP_001201509.1 | lipocalin family protein | - |
| GTF71_RS14895 | 329416..329913 | - | 498 | WP_000982260.1 | GNAT family N-acetyltransferase | - |
| GTF71_RS14900 | 329910..330182 | - | 273 | WP_000246253.1 | DUF1778 domain-containing protein | - |
| GTF71_RS14905 | 330575..330700 | + | 126 | WP_001900195.1 | DUF645 family protein | - |
| GTF71_RS14910 | 330716..330754 | + | 39 | WP_106019118.1 | hypothetical protein | - |
| GTF71_RS14915 | 330950..331396 | + | 447 | WP_000006157.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | catB9 | - | 306926..439292 | 132366 | |
| inside | Integron | - | - | 312006..438916 | 126910 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 106 a.a. Molecular weight: 12158.97 Da Isoelectric Point: 9.7495
>T145843 WP_001180243.1 NZ_CP047300:c326529-326212 [Vibrio cholerae O1 biovar El Tor]
MQNKQYKLSQLAQEHLLKIKHYTIENFAEAQWQKYKSTLLSGFQTLADNPGLGKSCEDIYQNGFYFPVGKHMAYYTKEAN
FILIVAVLGQSQLPQKHLKQSRFVS
MQNKQYKLSQLAQEHLLKIKHYTIENFAEAQWQKYKSTLLSGFQTLADNPGLGKSCEDIYQNGFYFPVGKHMAYYTKEAN
FILIVAVLGQSQLPQKHLKQSRFVS
Download Length: 318 bp
>T145843 NZ_CP062702:c2789248-2789072 [Escherichia coli O157:H7]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA
Antitoxin
Download Length: 81 a.a. Molecular weight: 8961.25 Da Isoelectric Point: 5.6630
>AT145843 WP_000557292.1 NZ_CP047300:c326790-326548 [Vibrio cholerae O1 biovar El Tor]
MHTLTANDAKRNFGELLLSAQREPVIISKNSKNTVVVMSIKDFEELEAMKLDYLKHCFESAQKDLDSGKTVDGATFLNTL
MHTLTANDAKRNFGELLLSAQREPVIISKNSKNTVVVMSIKDFEELEAMKLDYLKHCFESAQKDLDSGKTVDGATFLNTL
Download Length: 243 bp
>AT145843 NZ_CP062702:c2789026-2788610 [Escherichia coli O157:H7]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
GCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATTAAATAGTCATGATCACTTTATTGAAGTACCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAAGAGAT
TACTCGCCTATTTAACTTGCATCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
GCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATTAAATAGTCATGATCACTTTATTGAAGTACCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAAGAGAT
TACTCGCCTATTTAACTTGCATCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0K9UJR8 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | Q7DCR7 |