198981

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /BrnT(toxin)
Location 334822..335320 Replicon chromosome
Accession NZ_CP072848
Organism Vibrio cholerae strain A1552

Toxin (Protein)


Gene name - Uniprot ID Q9KMK7
Locus tag J9265_RS15285 Protein ID WP_000589156.1
Coordinates 334822..335088 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q9KMK6
Locus tag J9265_RS15290 Protein ID WP_000643598.1
Coordinates 335075..335320 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J9265_RS19010 330350..330448 + 99 WP_223225486.1 DUF3709 domain-containing protein -
J9265_RS15235 (J9265_15235) 330648..330749 + 102 WP_001921603.1 hypothetical protein -
J9265_RS15240 (J9265_15240) 330739..331125 + 387 WP_000703163.1 VOC family protein -
J9265_RS15245 (J9265_15245) 331320..331571 + 252 WP_001890111.1 TIGR03643 family protein -
J9265_RS15250 (J9265_15250) 331544..331693 + 150 WP_071908333.1 DUF3265 domain-containing protein -
J9265_RS15255 (J9265_15255) 331785..332027 + 243 WP_000107461.1 hypothetical protein -
J9265_RS15260 (J9265_15260) 332279..332557 + 279 WP_000280324.1 DUF3709 domain-containing protein -
J9265_RS19015 332989..333032 + 44 Protein_302 hypothetical protein -
J9265_RS19020 333014..333107 + 94 Protein_303 ggdef family protein -
J9265_RS19025 333076..333207 + 132 WP_001883067.1 hypothetical protein -
J9265_RS15275 (J9265_15275) 333379..333846 + 468 WP_001289288.1 OsmC family protein -
J9265_RS15280 (J9265_15280) 333974..334637 + 664 Protein_306 hypothetical protein -
J9265_RS19030 334627..334755 + 129 WP_088124358.1 DUF3265 domain-containing protein -
J9265_RS15285 (J9265_15285) 334822..335088 + 267 WP_000589156.1 BrnT family toxin Toxin
J9265_RS15290 (J9265_15290) 335075..335320 + 246 WP_000643598.1 hypothetical protein Antitoxin
J9265_RS15295 (J9265_15295) 335416..336210 + 795 WP_001911581.1 hypothetical protein -
J9265_RS19035 336207..336323 + 117 WP_086010881.1 DUF3265 domain-containing protein -
J9265_RS15300 (J9265_15300) 336313..336441 + 129 WP_071908338.1 general secretion pathway protein GspI -
J9265_RS15305 (J9265_15305) 336502..336684 + 183 WP_000923182.1 DUF645 family protein -
J9265_RS15310 (J9265_15310) 336900..337904 + 1005 WP_000964920.1 LD-carboxypeptidase -
J9265_RS15315 (J9265_15315) 338057..338416 + 360 WP_001071541.1 VOC family protein -
J9265_RS19040 338483..338668 + 186 WP_001999468.1 hypothetical protein -
J9265_RS19045 338800..338922 + 123 WP_001937972.1 DUF3709 domain-containing protein -
J9265_RS15325 (J9265_15325) 339190..339696 + 507 WP_000393074.1 hypothetical protein -
J9265_RS15330 (J9265_15330) 339853..340239 + 387 WP_000703163.1 VOC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 306914..436175 129261
inside Integron - - 311994..435799 123805


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(6-81)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10092.34 Da        Isoelectric Point: 7.3171

>T198981 WP_000589156.1 NZ_CP072848:334822-335088 [Vibrio cholerae]
MIKFEFDENKSRSNLEKHGIDFHTAQGLWNDSDLIEIPANTSDEPRYLVVGLLNGKHWSGVITYRGTNIRIISVRRSRKA
EVSLYESA

Download         Length: 267 bp

>T198981 NZ_CP097079:c4589499-4589158 [Klebsiella pneumoniae]
ATGAAAACTCTACCTGCAACAACTCCGCAGGCGGCGACGCTATGTCTGTCGCCCGTAACTGTCTGGCAAATGCTGCTTGC
ACGCCTGCTGGAACAGCATTATGGCCTGACACTCAACGACACGCCGTTCAGTGATGAAACGGTAATTCAGGAACATATCG
ATGCCGGTATATCTTTGGCTGATGCCGTTAATTTTCTGGTGGAAAAGTACGGGCTGGTTCGTATTGATCGCAGAGGATTC
AACTGGGAAGAACAGTCCCCATATCTGCGGGCAGTCGATATTCTGCGGGCGCGACAGGCAACTGGTTTATTGAAAAGAAA
TCGTATTAGCGCGGCACGGTGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9478.77 Da        Isoelectric Point: 6.4832

>AT198981 WP_000643598.1 NZ_CP072848:335075-335320 [Vibrio cholerae]
MKAHEFDAKFESDDDDIVMDLDLSQAKRPMHKQKRVNVDFPAWMLESLDREASRIGVTRQSIIKIWLAERLESVSHHSSV
R

Download         Length: 246 bp

>AT198981 NZ_CP097079:c4589861-4589520 [Klebsiella pneumoniae]
ATGAAATCTACTGACTCAGAGAACGATTCATTTCTCCAGTGGGGTCTGAATCGTAATGTGACACCTTGCTTTGGCGCTCG
TCTGGTACAGGAGGGAAACCGGCTGCACTATCTGGCTGACCGGGCCAGTATCACCGGAAAGTTCAGCGAAGCAGAATGTC
TTAAGCTGGATGTGGCATTCCCGCATTTTATCAGCCAGATGGAATCGATGCTGACTACTGGTGAAATGAATCCTCGCCAT
GCCCACTGTGTCACCCTGTACCACAATGGTTTCACCTGCGAAGCCGATACCCTTGGCAGTTGCGGCTACGTATACATCGC
CGTTTACCCCACTCATCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A271VMP7

Antitoxin

Source ID Structure
AlphaFold DB A0A271VME2

References