Detailed information of TA system TA058216

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): DhiAT/-
• Location: 337470..338254
• Replicon: chromosome
• Accession: NZ_CP013302
• Organism: Vibrio cholerae strain C5

Toxin (Protein)

• Gene name: dhiT
• Uniprot ID: A0A086SLD6
• Locus tag: ASZ80_RS15850
• Protein ID: WP_001114075.1
• Coordinates: 337470..337739 (+)
• Length: 90 a.a.

Antitoxin (Protein)

• Gene name: dhiA
• Uniprot ID: C3LUY7
• Locus tag: ASZ80_RS15855
• Protein ID: WP_000921692.1
• Coordinates: 337733..338254 (+)
• Length: 174 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ASZ80_RS15790	332880..333179	-	300	WP_000802136.1	type II toxin-antitoxin system RelE/ParE family toxin	-
ASZ80_RS15795	333176..333418	-	243	WP_001107719.1	type II toxin-antitoxin system ParD family antitoxin	-
ASZ80_RS15805	333837..333914	+	78	WP_071908337.1	DUF645 family protein	-
ASZ80_RS20860	333918..333944	+	27	Protein_299	hypothetical protein	-
ASZ80_RS20945	334530..334673	+	144	WP_001900215.1	hypothetical protein	-
ASZ80_RS20420	334767..334946	+	180	Protein_301	DUF645 family protein	-
ASZ80_RS15830	335164..335592	+	429	WP_000620002.1	N-acetyltransferase	-
ASZ80_RS15840	336180..336662	+	483	WP_000422940.1	GNAT family N-acetyltransferase	-
ASZ80_RS15850	337470..337739	+	270	WP_001114075.1	DUF4160 domain-containing protein	Toxin
ASZ80_RS15855	337733..338254	+	522	WP_000921692.1	DUF2442 domain-containing protein	Antitoxin
ASZ80_RS20440	338311..338424	+	114	WP_001894981.1	hypothetical protein	-
ASZ80_RS15860	338393..339229	+	837	WP_000242986.1	hypothetical protein	-
ASZ80_RS15865	339394..340032	+	639	WP_000230118.1	HD domain-containing protein	-
ASZ80_RS20445	340122..340282	+	161	Protein_309	DUF3709 domain-containing protein	-
ASZ80_RS15870	340303..340524	+	222	WP_012705854.1	DUF3709 domain-containing protein	-
ASZ80_RS15880	340844..341164	+	321	WP_001909340.1	DUF1778 domain-containing protein	-
ASZ80_RS15885	341161..341694	+	534	WP_000118351.1	GNAT family N-acetyltransferase	-
ASZ80_RS15890	341932..342210	+	279	WP_000280324.1	DUF3709 domain-containing protein	-
ASZ80_RS15895	342611..342835	+	225	WP_001894423.1	DUF3709 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	catB9	-	304694..469286	164592
	Similar MGE(s) Similar MGE(s) is defined as other TA-related MGE(s) with Mash distance < 0.01 to this MGE. Detail Genome accession Organism MGE type Related TA Coordinates Mash distance View NC_002506 Vibrio cholerae O1 biovar El Tor str. N16961 Integron TA000164, TA000169, TA000166, TA000167, TA000179, TA000170, TA000171, TA000172, TA000173, TA000174, TA000175, TA000176, TA000177, TA000178, TA000168, TA000165, TA010030, TA010035 309750..435387 0.005	inside	Integron	-	-	309774..468910	159136

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF4160 (9-74)

Antitoxin

• Protein of unknown function DUF2442 (4-59)

Sequences

Toxin

Protein

• Length: 90 a.a.
• Molecular weight: 10310.94 Da
• Isoelectric Point: 6.6303

>T58216 WP_001114075.1 NZ_CP013302:337470-337739 [Vibrio cholerae]
MPEIDALLGLSFCLYFFDNKQHKLPHIHVKYGSYELIIAIETGECLEGYLPNKQRKRAENHILEHREQLMVMWNKAVNGE
NPGKLGDLC

Nucleotide

• Length: 270 bp

>T58216 NZ_CP013302:337470-337739 [Vibrio cholerae]
ATGCCAGAGATTGATGCCCTATTAGGCCTTTCATTTTGCTTGTACTTCTTTGATAACAAGCAGCATAAATTGCCTCATAT
TCACGTTAAGTACGGTAGTTACGAGCTAATTATTGCTATTGAAACAGGTGAGTGTTTAGAGGGTTACTTACCCAATAAAC
AACGAAAACGTGCTGAAAACCATATTCTTGAACATCGAGAGCAATTGATGGTGATGTGGAATAAAGCGGTGAATGGTGAA
AATCCAGGTAAGTTAGGTGATTTATGTTGA

Antitoxin

Protein

• Length: 174 a.a.
• Molecular weight: 19439.04 Da
• Isoelectric Point: 6.7342

>AT58216 WP_000921692.1 NZ_CP013302:337733-338254 [Vibrio cholerae]
MLKVIDVDFVSDHTLELTFNDGYQGYADLSVYFKKTPFSEIKDFKRFSLTRDGSLNWDGNELTAATLRDITKGSQKSVEL
SFNVQEMEAVIKQASWESMMEGRPDILQAAIRSYVEQFGHGQVIAKAGIKSRTSAYRSLKPETTPNFGTLVQLGHAVIEL
AKDRTVANKEPRI

Nucleotide

• Length: 522 bp

>AT58216 NZ_CP013302:337733-338254 [Vibrio cholerae]
ATGTTGAAAGTCATAGATGTTGATTTTGTCTCAGACCATACATTAGAACTGACGTTCAATGATGGTTACCAAGGCTATGC
CGACTTGTCGGTATACTTTAAAAAAACACCGTTTTCAGAAATTAAGGACTTTAAACGCTTTTCCTTGACTCGTGATGGCT
CGTTAAATTGGGATGGTAATGAGTTAACGGCCGCGACACTCCGTGACATAACCAAGGGCTCACAAAAGTCGGTGGAGTTA
AGTTTTAATGTTCAAGAAATGGAAGCCGTCATCAAACAGGCCTCATGGGAATCGATGATGGAGGGGCGTCCCGACATCTT
GCAAGCGGCTATTCGTTCTTACGTAGAGCAGTTTGGTCATGGTCAAGTTATTGCAAAGGCGGGTATAAAAAGTCGTACGA
GTGCTTATCGCTCCTTGAAGCCAGAAACAACGCCAAACTTTGGCACACTAGTTCAGTTAGGGCACGCCGTCATCGAACTA
GCGAAAGATAGAACAGTGGCAAACAAGGAACCACGCATATAA

Structures

Toxin

• AlphaFold DB: A0A086SLD6

Antitoxin

• AlphaFold DB: C3LUY7