Detailed information of TA system TA058217

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /DUF1778(antitoxin)
• Location: 340844..341694
• Replicon: chromosome
• Accession: NZ_CP013302
• Organism: Vibrio cholerae strain C5

Toxin (Protein)

• Gene name: -
• Uniprot ID: Q9KM94
• Locus tag: ASZ80_RS15885
• Protein ID: WP_000118351.1
• Coordinates: 341161..341694 (+)
• Length: 178 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: ASZ80_RS15880
• Protein ID: WP_001909340.1
• Coordinates: 340844..341164 (+)
• Length: 107 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ASZ80_RS15840	336180..336662	+	483	WP_000422940.1	GNAT family N-acetyltransferase	-
ASZ80_RS15850	337470..337739	+	270	WP_001114075.1	DUF4160 domain-containing protein	-
ASZ80_RS15855	337733..338254	+	522	WP_000921692.1	DUF2442 domain-containing protein	-
ASZ80_RS20440	338311..338424	+	114	WP_001894981.1	hypothetical protein	-
ASZ80_RS15860	338393..339229	+	837	WP_000242986.1	hypothetical protein	-
ASZ80_RS15865	339394..340032	+	639	WP_000230118.1	HD domain-containing protein	-
ASZ80_RS20445	340122..340282	+	161	Protein_309	DUF3709 domain-containing protein	-
ASZ80_RS15870	340303..340524	+	222	WP_012705854.1	DUF3709 domain-containing protein	-
ASZ80_RS15880	340844..341164	+	321	WP_001909340.1	DUF1778 domain-containing protein	Antitoxin
ASZ80_RS15885	341161..341694	+	534	WP_000118351.1	GNAT family N-acetyltransferase	Toxin
ASZ80_RS15890	341932..342210	+	279	WP_000280324.1	DUF3709 domain-containing protein	-
ASZ80_RS15895	342611..342835	+	225	WP_001894423.1	DUF3709 domain-containing protein	-
ASZ80_RS15905	343573..343962	+	390	WP_000491263.1	VOC family protein	-
ASZ80_RS15910	344095..344610	+	516	WP_000090008.1	hypothetical protein	-
ASZ80_RS15915	344751..345188	+	438	WP_001202554.1	NUDIX pyrophosphatase	-
ASZ80_RS15920	345349..345696	+	348	WP_000933409.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	catB9	-	304694..469286	164592
	Similar MGE(s) Similar MGE(s) is defined as other TA-related MGE(s) with Mash distance < 0.01 to this MGE. Detail Genome accession Organism MGE type Related TA Coordinates Mash distance View NC_002506 Vibrio cholerae O1 biovar El Tor str. N16961 Integron TA000164, TA000169, TA000166, TA000167, TA000179, TA000170, TA000171, TA000172, TA000173, TA000174, TA000175, TA000176, TA000177, TA000178, TA000168, TA000165, TA010030, TA010035 309750..435387 0.005	inside	Integron	-	-	309774..468910	159136

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (97-153)

Antitoxin

• Vibrio phage ICP1, Orf50 (22-98)

Sequences

Toxin

Protein

• Length: 178 a.a.
• Molecular weight: 20171.46 Da
• Isoelectric Point: 9.1432

>T58217 WP_000118351.1 NZ_CP013302:341161-341694 [Vibrio cholerae]
VSWGKEFVELSKSKHDRDSFDCGEQELNTFIKTQAAKHMQAGISRTMVLPSAHPLLNQKFAICAFYSVAPSSISRETLPA
QLAKKLPRYPIPVFLLAQLAVHKEFHGSGLGKVSLIRALKYLWEVNHHMRAYAIVVDCLTDSAQAFYTKFGFEVLCEHNE
RIRMFLPMKTVEQLFNQ

Nucleotide

• Length: 534 bp

>T58217 NZ_CP013302:341161-341694 [Vibrio cholerae]
GTGAGTTGGGGCAAAGAGTTTGTAGAACTTAGTAAATCAAAGCATGACCGCGACTCATTTGACTGTGGTGAGCAAGAGCT
AAACACATTTATCAAAACTCAAGCTGCAAAGCACATGCAAGCAGGTATTAGTCGAACAATGGTTTTACCTAGTGCTCACC
CACTGTTAAATCAAAAATTCGCTATTTGTGCCTTTTATAGTGTTGCACCGAGCTCAATCAGCCGAGAAACATTACCGGCA
CAATTAGCAAAGAAACTACCGAGGTATCCAATCCCTGTTTTTCTGTTGGCTCAGTTAGCTGTGCACAAAGAATTTCACGG
TTCTGGACTTGGAAAGGTCAGTCTAATCCGTGCGCTGAAGTACTTGTGGGAAGTGAATCATCACATGAGAGCATATGCAA
TAGTTGTGGATTGTCTGACAGATTCCGCTCAAGCGTTCTATACGAAGTTCGGCTTTGAAGTATTGTGCGAACATAATGAG
CGTATTCGTATGTTCTTACCGATGAAAACGGTAGAACAACTTTTTAATCAATAG

Antitoxin

Protein

• Length: 107 a.a.
• Molecular weight: 11759.53 Da
• Isoelectric Point: 4.9309

>AT58217 WP_001909340.1 NZ_CP013302:340844-341164 [Vibrio cholerae]
MAYNRSTDGMYPYAGGVMATARLDIRLDEEIKAKAEKASALLGLKSLTEYVVRLMDEDATHVIEEHESIMVKDSVFDEFM
AACNKVKAPNQALLEAVKFTEKSGIK

Nucleotide

• Length: 321 bp

>AT58217 NZ_CP013302:340844-341164 [Vibrio cholerae]
TTGGCCTATAATCGCTCAACTGACGGAATGTATCCGTACGCAGGAGGGGTTATGGCAACGGCACGTTTAGATATCCGCCT
TGATGAAGAGATCAAGGCAAAAGCCGAAAAGGCATCGGCTTTACTTGGTTTAAAAAGTCTCACTGAATATGTGGTGAGAC
TTATGGACGAAGATGCGACTCATGTTATTGAGGAGCATGAAAGTATTATGGTTAAAGACAGTGTTTTTGACGAGTTTATG
GCTGCGTGTAATAAAGTAAAAGCACCGAATCAAGCTTTGCTTGAAGCTGTTAAATTTACAGAGAAGAGCGGTATCAAGTG
A

Structures

Toxin

• AlphaFold DB: Q9KM94