145824

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /GNAT-DUF1778
Location 326745..327511 Replicon chromosome
Accession NZ_CP047298
Organism Vibrio cholerae O1 biovar El Tor strain C6709

Toxin (Protein)


Gene name - Uniprot ID Q9K2P7
Locus tag GTF73_RS15215 Protein ID WP_000982260.1
Coordinates 326745..327242 (-) Length 166 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q9K2J6
Locus tag GTF73_RS15220 Protein ID WP_000246253.1
Coordinates 327239..327511 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GTF73_RS15165 322187..322891 + 705 WP_000087610.1 HNH endonuclease -
GTF73_RS15170 323049..323387 + 339 WP_000713853.1 hypothetical protein -
GTF73_RS15175 323541..323858 - 318 WP_001180243.1 type II toxin-antitoxin system RelE/ParE family toxin -
GTF73_RS15180 323877..324119 - 243 WP_000557292.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
GTF73_RS15185 324363..324749 + 387 WP_001015867.1 NUDIX hydrolase -
GTF73_RS15190 324806..324919 + 114 WP_001900214.1 hypothetical protein -
GTF73_RS15195 324868..325149 + 282 WP_001894429.1 DUF1289 domain-containing protein -
GTF73_RS15200 325125..325283 - 159 WP_001886450.1 DUF1196 family protein -
GTF73_RS15205 325407..325943 + 537 WP_000469482.1 GNAT family N-acetyltransferase -
GTF73_RS15210 326080..326595 + 516 WP_001201509.1 lipocalin family protein -
GTF73_RS15215 326745..327242 - 498 WP_000982260.1 GNAT family N-acetyltransferase Toxin
GTF73_RS15220 327239..327511 - 273 WP_000246253.1 DUF1778 domain-containing protein Antitoxin
GTF73_RS15225 327904..328029 + 126 WP_001900195.1 DUF645 family protein -
GTF73_RS15230 328045..328083 + 39 WP_106019118.1 hypothetical protein -
GTF73_RS15235 328279..328725 + 447 WP_000006157.1 hypothetical protein -
GTF73_RS15240 328873..329142 - 270 WP_000277238.1 type II toxin-antitoxin system YafQ family toxin -
GTF73_RS15245 329135..329413 - 279 WP_001258569.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
GTF73_RS15250 329699..329977 + 279 WP_001921601.1 DUF3709 domain-containing protein -
GTF73_RS15255 330229..330435 + 207 Protein_294 DUF3709 domain-containing protein -
GTF73_RS15260 330635..330736 + 102 WP_001921603.1 hypothetical protein -
GTF73_RS15265 330726..331112 + 387 WP_000703163.1 VOC family protein -
GTF73_RS15270 331307..331558 + 252 WP_001890111.1 TIGR03643 family protein -
GTF73_RS15275 331531..331680 + 150 WP_071908333.1 DUF3265 domain-containing protein -
GTF73_RS15280 331772..332014 + 243 WP_000107461.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 306901..436162 129261
inside Integron - - 311981..435786 123805


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(86-152)

Antitoxin

Vibrio phage ICP1, Orf50

(7-86)


Sequences

Toxin        


Download         Length: 166 a.a.        Molecular weight: 18527.18 Da        Isoelectric Point: 8.7753

>T145824 WP_000982260.1 NZ_CP047298:c327242-326745 [Vibrio cholerae O1 biovar El Tor]
MMNTVLLDKDKHDRNRFNCGTEALNNYLKVMASQQAKKDNTRTFVLEDDNNSAYIIGFYTLTMTPIDLKALPDKLQKKHQ
SSTSGGLIARLAVDDRYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKHFYERYGFQAFQDAENKLFITIADI
RASLG

Download         Length: 498 bp

>T145824 NZ_CP062700:c4686180-4685866 [Escherichia coli O157:H7]
ATGCAATTTACGGTATACCGCAGTCGCAGCAGGAACGCCGCGTTTCCCTTTGTTATCGATGTTACCAGCGACATTATTGG
TGTGATTAATCGCCGTATTGTTATTCCATTAACACCTATTGAACGATTTAGCCGTATTCGCCCACCAGAACGGCTTAACC
CAATCCTTTTACTGGTAGACGGCAAAGAATATGTGCTCATGACGCATGAGACTGCAACTGTTCCAGTTAACGCGCTGGGA
ACGAAATTTTGCGATGCCAGCGCGCACCGAACGTTGATTAAAGGAGCATTAGATTTTATGCTCGACGGGATTTAA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9683.22 Da        Isoelectric Point: 6.2988

>AT145824 WP_000246253.1 NZ_CP047298:c327511-327239 [Vibrio cholerae O1 biovar El Tor]
MATTLPRITARVDVDTQDLLAKAAALAGMSSINSFVLNAAIEKAKQVIEREQALKLSQADAVLLMEALDNPAVVNAKLKL
ASERYESKTQ

Download         Length: 273 bp

>AT145824 NZ_CP062700:c4686416-4686183 [Escherichia coli O157:H7]
ATGACTGCAAAACGTACCACACAAAGTGTGACCGTCACCGTCGACCGTGAGTTAGTCAATCGCGCTCGTGATGCAGGCTT
AAATATGAGCGCCACCCTTACGGTTGCGCTCAATGCTGAACTTAAAAAACATGCAGCAACACGTTGGCGTGAAGAGAACG
CTGAAGCTATCGCTGCGTTAAATCAATTGGCTGATGAAACCGGATGTTTCTCTGATGAGTACCGGAGCTTCTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Q0KGB1

Antitoxin

Source ID Structure
AlphaFold DB A0A0F2IC79

References