Detailed information of TA system TA045806

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-RelB
• Location: 343150..343709
• Replicon: chromosome
• Accession: NZ_CP006948
• Organism: Vibrio cholerae O1 str. KW3

Toxin (Protein)

• Gene name: relE
• Uniprot ID: Q9K2M8
• Locus tag: N900_RS15630
• Protein ID: WP_000578476.1
• Coordinates: 343150..343428 (-)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: Q9L991
• Locus tag: N900_RS15635
• Protein ID: WP_000381183.1
• Coordinates: 343425..343709 (-)
• Length: 95 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
N900_RS15590	338228..338734	+	507	WP_000393074.1	hypothetical protein	-
N900_RS15595	338891..339277	+	387	WP_000703163.1	VOC family protein	-
N900_RS15600	339534..339737	+	204	WP_001911580.1	hypothetical protein	-
N900_RS15605	339932..340183	+	252	WP_001890111.1	TIGR03643 family protein	-
N900_RS19490	340156..340305	+	150	WP_071908333.1	DUF3265 domain-containing protein	-
N900_RS15610	340452..340877	+	426	WP_000415750.1	hypothetical protein	-
N900_RS15615	341083..341706	+	624	WP_000247070.1	DUF1349 domain-containing protein	-
N900_RS15620	341919..342398	+	480	WP_000009888.1	lecithin retinol acyltransferase family protein	-
N900_RS15625	342586..342999	+	414	WP_000049420.1	VOC family protein	-
N900_RS15630	343150..343428	-	279	WP_000578476.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
N900_RS15635	343425..343709	-	285	WP_000381183.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
N900_RS19500	343904..344417	+	514	Protein_320	lipocalin family protein	-
N900_RS15645	344482..345078	+	597	WP_000255434.1	hypothetical protein	-
N900_RS15650	345470..345652	+	183	WP_000923182.1	DUF645 family protein	-
N900_RS15655	345852..346325	+	474	WP_001161076.1	GrpB family protein	-
N900_RS19510	346340..346432	+	93	WP_014378730.1	DUF3265 domain-containing protein	-
N900_RS15660	346474..347100	+	627	WP_000365424.1	LysE family translocator	-
N900_RS15665	347223..347921	+	699	WP_001890502.1	hypothetical protein	-
N900_RS19515	347931..348041	+	111	WP_079857360.1	DUF3265 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	catB9	-	304645..411088	106443
	Similar MGE(s) Similar MGE(s) is defined as other TA-related MGE(s) with Mash distance < 0.01 to this MGE. Detail Genome accession Organism MGE type Related TA Coordinates Mash distance View NC_002506 Vibrio cholerae O1 biovar El Tor str. N16961 Integron TA000164, TA000169, TA000166, TA000167, TA000179, TA000170, TA000171, TA000172, TA000173, TA000174, TA000175, TA000176, TA000177, TA000178, TA000168, TA000165, TA010030, TA010035 309750..435387 0.004	inside	Integron	-	-	309725..410760	101035

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (2-89)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (5-70)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10819.59 Da
• Isoelectric Point: 5.1651

>T45806 WP_000578476.1 NZ_CP006948:c343428-343150 [Vibrio cholerae O1 str. KW3]
MIFWEEASLNDREKIFEFLYDFNPAAAKKTDELIEAKVENLLEQPLIGVQRDGIRGRLLIIPEISMIVSYWVDGSKIRIM
RVLHQKQKFPND

Nucleotide

• Length: 279 bp

>T45806 NZ_CP006948:c343428-343150 [Vibrio cholerae O1 str. KW3]
ATGATTTTCTGGGAAGAAGCATCTCTCAATGATCGTGAGAAAATTTTCGAATTTCTCTACGACTTTAACCCAGCAGCGGC
TAAAAAAACGGATGAGCTCATAGAAGCCAAAGTCGAAAATTTGCTTGAGCAACCACTAATCGGTGTTCAGCGTGATGGCA
TTAGAGGCAGATTGCTTATTATCCCTGAGATATCAATGATTGTTTCGTATTGGGTTGATGGTTCTAAAATTCGAATAATG
CGTGTACTACATCAGAAACAAAAATTTCCAAACGACTGA

Antitoxin

Protein

• Length: 95 a.a.
• Molecular weight: 10901.25 Da
• Isoelectric Point: 8.0775

>AT45806 WP_000381183.1 NZ_CP006948:c343709-343425 [Vibrio cholerae O1 str. KW3]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKALSHDAWLTEQVNQAFEKFDSGKAVFIEHDIAKAR
MAERKAKIRNRGHA

Nucleotide

• Length: 285 bp

>AT45806 NZ_CP006948:c343709-343425 [Vibrio cholerae O1 str. KW3]
ATGGATACTAGAATTCAATTTCGTGTAGACGAAGAAACAAAACGTTTAGCTCAACAAATGGCTGAAAGCCAAGGTCGAAC
TCTTAGCGATGCTTGCCGTGAACTCACTGAACAATTAGCTGAGCAGCAACGCAAGGCATTATCTCACGATGCATGGCTAA
CTGAACAAGTGAATCAAGCATTTGAGAAGTTCGACTCAGGAAAAGCAGTATTCATTGAACATGACATCGCCAAAGCACGA
ATGGCTGAACGTAAAGCTAAAATCCGAAATCGAGGCCACGCATGA

Structures

Toxin

• AlphaFold DB: Q9K2M8

Antitoxin

• AlphaFold DB: A0A067BL33