Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 382751..383366 Replicon chromosome
Accession NZ_CP013318
Organism Vibrio cholerae strain NCTC5395

Toxin (Protein)


Gene name higB Uniprot ID Q9KMG5
Locus tag ASZ85_RS16065 Protein ID WP_001162670.1
Coordinates 382751..383038 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag ASZ85_RS16070 Protein ID WP_001232701.1
Coordinates 383049..383366 (+) Length 106 a.a.

Genomic Context

ASZ85_RS16020ASZ85_RS16025ASZ85_RS16030ASZ85_RS16035ASZ85_RS21000ASZ85_RS16050ASZ85_RS16060ASZ85_RS16065ASZ85_RS16070ASZ85_RS21445ASZ85_RS16080ASZ85_RS16085ASZ85_RS16090ASZ85_RS21020ASZ85_RS21025ASZ85_RS16095ASZ85_RS16100ASZ85_RS16105ASZ85_RS16110ASZ85_RS16115ASZ85_RS16120
Location: 378243..378500 (258 bp)
Type: Others
Protein ID: WP_000861987.1
Location: 378488..378790 (303 bp)
Type: Others
Protein ID: WP_000229318.1
Location: 379079..379303 (225 bp)
Type: Others
Protein ID: WP_001894423.1
Location: 379747..379866 (120 bp)
Type: Others
Protein ID: WP_071919600.1
Location: 379870..379923 (54 bp)
Type: Others
Protein ID: Protein_360
Location: 380525..381529 (1005 bp)
Type: Others
Protein ID: WP_000964931.1
Location: 382304..382484 (181 bp)
Type: Others
Protein ID: Protein_362
Location: 382751..383038 (288 bp)
Type: Toxin
Protein ID: WP_001162670.1
Location: 383049..383366 (318 bp)
Type: Antitoxin
Protein ID: WP_001232701.1
Location: 383363..383473 (111 bp)
Type: Others
Protein ID: WP_134814058.1
Location: 383519..384058 (540 bp)
Type: Others
Protein ID: WP_000099372.1
Location: 384203..384637 (435 bp)
Type: Others
Protein ID: WP_000453680.1
Location: 384864..385142 (279 bp)
Type: Others
Protein ID: WP_001921601.1
Location: 385394..385600 (207 bp)
Type: Others
Protein ID: Protein_369
Location: 385800..385901 (102 bp)
Type: Others
Protein ID: WP_001921603.1
Location: 385891..386277 (387 bp)
Type: Others
Protein ID: WP_000703163.1
Location: 386472..386723 (252 bp)
Type: Others
Protein ID: WP_001890111.1
Location: 386696..386845 (150 bp)
Type: Others
Protein ID: WP_071908333.1
Location: 387058..387210 (153 bp)
Type: Others
Protein ID: WP_001884520.1
Location: 387411..387782 (372 bp)
Type: Others
Protein ID: WP_001164080.1
Location: 388078..388260 (183 bp)
Type: Others
Protein ID: WP_001900194.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
ASZ85_RS16020378243..378500+258WP_000861987.1type II toxin-antitoxin system Phd/YefM family antitoxin-
ASZ85_RS16025378488..378790+303WP_000229318.1type II toxin-antitoxin system RelE/ParE family toxin-
ASZ85_RS16030379079..379303+225WP_001894423.1DUF3709 domain-containing protein-
ASZ85_RS16035379747..379866+120WP_071919600.1DUF645 family protein-
ASZ85_RS21000379870..379923+54Protein_360DUF645 family protein-
ASZ85_RS16050380525..381529+1005WP_000964931.1LD-carboxypeptidase-
ASZ85_RS16060382304..382484+181Protein_362DUF645 family protein-
ASZ85_RS16065382751..383038+288WP_001162670.1type II toxin-antitoxin system RelE/ParE family toxinToxin
ASZ85_RS16070383049..383366+318WP_001232701.1HigA family addiction module antidote proteinAntitoxin
ASZ85_RS21445383363..383473+111WP_134814058.1DUF3265 domain-containing protein-
ASZ85_RS16080383519..384058+540WP_000099372.1hypothetical protein-
ASZ85_RS16085384203..384637+435WP_000453680.1GNAT family N-acetyltransferase-
ASZ85_RS16090384864..385142+279WP_001921601.1DUF3709 domain-containing protein-
ASZ85_RS21020385394..385600+207Protein_369DUF3709 domain-containing protein-
ASZ85_RS21025385800..385901+102WP_001921603.1hypothetical protein-
ASZ85_RS16095385891..386277+387WP_000703163.1VOC family protein-
ASZ85_RS16100386472..386723+252WP_001890111.1TIGR03643 family protein-
ASZ85_RS16105386696..386845+150WP_071908333.1DUF3265 domain-containing protein-
ASZ85_RS16110387058..387210+153WP_001884520.1DUF645 family protein-
ASZ85_RS16115387411..387782+372WP_001164080.1nucleotide pyrophosphohydrolase-
ASZ85_RS16120388078..388260+183WP_001900194.1DUF645 family protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic island--338285..496833158548
insideIntegron--343365..496457153092


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(2-95)

Antitoxin

Cro/C1-type helix-turn-helix domain

(12-69)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11349.95 Da        Isoelectric Point: 6.7187

>T58397 WP_001162670.1 NZ_CP013318:382751-383038 [Vibrio cholerae]
MALEFKDKWLEQFYEDDKRHRLIPSSIENALFRKLEILDAAQAESDLRIPPGNRFEHLEGNLKGWCSIRVNKQYRLIFQW
VDGVALNTYLDPHKY

Download         Length: 288 bp

>T58397 NZ_CP013318:382751-383038 [Vibrio cholerae]
ATGGCATTAGAATTTAAAGATAAGTGGTTAGAGCAGTTTTACGAGGATGATAAACGACATCGTTTAATTCCAAGTAGCAT
AGAGAATGCTCTATTTCGGAAGCTGGAAATCTTAGATGCAGCTCAAGCTGAATCAGACTTAAGAATTCCACCGGGTAATC
GTTTTGAACATCTTGAAGGAAATCTTAAAGGTTGGTGTTCAATTCGAGTGAACAAACAGTATCGTTTGATTTTTCAGTGG
GTTGATGGTGTTGCACTAAATACTTACTTAGACCCACATAAGTATTGA

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11705.63 Da        Isoelectric Point: 10.4711

>AT58397 WP_001232701.1 NZ_CP013318:383049-383366 [Vibrio cholerae]
MRKTKRRPVSVGEMLKVEFLEPMGITSKALAEAMGVHRNTVSNLINGGVLTAPVAIKLAAALGNTPEFWLNIQHAVDLWD
TRNRYQEEAKFVKPLFVSLEQSART

Download         Length: 318 bp

>AT58397 NZ_CP013318:383049-383366 [Vibrio cholerae]
ATGCGTAAGACAAAACGTCGTCCAGTTAGCGTTGGGGAAATGTTAAAAGTTGAATTTCTTGAACCAATGGGCATCACATC
AAAAGCGCTCGCTGAAGCGATGGGCGTACACAGAAATACGGTCAGTAATTTAATTAATGGTGGTGTGTTAACAGCTCCGG
TAGCAATCAAGTTAGCCGCGGCATTAGGTAACACACCAGAATTTTGGCTTAACATTCAACATGCAGTTGATCTTTGGGAT
ACGAGAAATCGTTATCAAGAAGAAGCAAAGTTTGTAAAGCCGTTGTTTGTTTCGCTGGAACAAAGCGCACGTACATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0F2HI36

Antitoxin

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Source
ID
Structure
No matching records found

References