211912

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc(toxin)
Location 949258..949829 Replicon chromosome
Accession NZ_CP080466
Organism Vibrio cholerae strain ICDC-VC3741

Toxin (Protein)


Gene name doc Uniprot ID Q9KMA2
Locus tag K1T75_RS17920 Protein ID WP_000351248.1
Coordinates 949258..949659 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID Q8GNG3
Locus tag K1T75_RS18865 Protein ID WP_001080654.1
Coordinates 949659..949829 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K1T75_RS17875 944552..944839 - 288 WP_000426470.1 hypothetical protein -
K1T75_RS17880 944991..945659 - 669 WP_000043871.1 hypothetical protein -
K1T75_RS18845 945676..945738 - 63 Protein_821 acetyltransferase -
K1T75_RS17885 945890..946162 + 273 WP_000246253.1 DUF1778 domain-containing protein -
K1T75_RS17890 946159..946656 + 498 WP_000982260.1 GNAT family N-acetyltransferase -
K1T75_RS18850 946673..946741 - 69 Protein_824 acetyltransferase -
K1T75_RS17895 946858..946962 - 105 WP_228840819.1 DUF645 family protein -
K1T75_RS18855 947153..947275 - 123 Protein_826 acetyltransferase -
K1T75_RS17900 947332..947787 - 456 WP_001245327.1 GNAT family N-acetyltransferase -
K1T75_RS17905 947915..948202 - 288 WP_000221354.1 type II toxin-antitoxin system RelE/ParE family toxin -
K1T75_RS17910 948192..948443 - 252 WP_001250179.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
K1T75_RS17915 948657..949070 - 414 WP_000049417.1 VOC family protein -
K1T75_RS18860 949145..949255 - 111 WP_082798255.1 DUF3265 domain-containing protein -
K1T75_RS17920 949258..949659 - 402 WP_000351248.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
K1T75_RS18865 949659..949829 - 171 WP_001080654.1 hypothetical protein Antitoxin
K1T75_RS18870 949953..950351 - 399 Protein_834 GNAT family N-acetyltransferase -
K1T75_RS17930 950488..950794 - 307 Protein_835 CatB-related O-acetyltransferase -
K1T75_RS17935 950862..951842 + 981 WP_000019370.1 IS5-like element ISVch5 family transposase -
K1T75_RS17940 951967..952122 - 156 WP_000751734.1 hypothetical protein -
K1T75_RS17945 952290..952724 - 435 WP_000256036.1 GNAT family N-acetyltransferase -
K1T75_RS17950 952861..953175 - 315 WP_000071008.1 DNA-binding transcriptional regulator -
K1T75_RS17955 953162..953494 - 333 WP_000843587.1 type II toxin-antitoxin system RelE/ParE family toxin -
K1T75_RS17960 953835..954062 - 228 WP_001894457.1 DUF1289 domain-containing protein -
K1T75_RS17965 954011..954124 - 114 WP_001889158.1 hypothetical protein -
K1T75_RS17970 954290..954511 - 222 WP_032468461.1 DUF1289 domain-containing protein -
K1T75_RS17975 954520..954634 - 115 Protein_844 acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 932680..1039634 106954
inside Integron - - 933056..1032792 99736
flank IS/Tn - - 950862..951842 980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(1-132)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14608.71 Da        Isoelectric Point: 4.0128

>T211912 WP_000351248.1 NZ_CP080466:c949659-949258 [Vibrio cholerae]
MDIICFPFERVIEINAFILKTEPGMKGAVDIPKLQGALGRIDNAIVYEGLDDVFEIAAKYTACIAVSHALPDANKRTGLA
VALEYLSLNDFELTQENDLLADAVRDLVIGIINETDFADILYAQYAKEQNSAL

Download         Length: 402 bp

>T211912 NZ_CP106839:c86115-85783 [Klebsiella michiganensis]
ATGGTAAAACGCTACGTGCCAGATGCAGGTGATCTTATCTGGATAGATTTCGATCCCGTTGCCGGGCATGAGCAGGGAGG
ACACAGACCTGCCGTTGTCCTGAGTCCCTTCGCCTACAACAACAAAGTTGGCCTGCTGCTGTGTGTGCCATGCACTACGC
AAATCAAGGGCTACCCCTTTGAAGTCACGCTATCGGGTAGCAAAGAAGGGGTGGCGCTGTCGGATCAGGTTACATGCGTT
GACTGGCGGGCCAGGAAAGTGACCAAGAAGGCCACGGTTAACAGTACTGAACTTGCAGAAATACGGGCAAAAGCGAAAGC
GCTGATTGGTTGA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6287.35 Da        Isoelectric Point: 10.7274

>AT211912 WP_001080654.1 NZ_CP080466:c949829-949659 [Vibrio cholerae]
MNRKVEAYGVDAVERPKIKASKKLDLTGDAGRQIVKSETKLALRTHQKTFTKLADM

Download         Length: 171 bp

>AT211912 NZ_CP106839:c86360-86115 [Klebsiella michiganensis]
ATGGCTCAAGCAATAGTTAAAAAATGGGGTAACAGCCCGTCAGTCCGGTTGCCAGTGGCGGTGATGAAAGCAGCGTCGCT
AAAAGTTGATGATACTGTCGATATTGAGGTTGAGGATGGTCGTATCATCATTGTTCCTGTCAGACAGAAAGAGTATTCCC
TCGATGCATTGCTGGCCGGTATTTCCACCGATAATCTTCATGACAAAGCAGATTTCGGCCCGGCACAGGGTAAGGAACTA
CTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Q0PN34

Antitoxin

Source ID Structure
AlphaFold DB A0A1T4SJJ1

References