Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 367640..368255 Replicon chromosome
Accession NZ_CP024868
Organism Vibrio cholerae strain A1552

Toxin (Protein)


Gene name higB Uniprot ID Q9KMG5
Locus tag VCA1552_RS16230 Protein ID WP_001162670.1
Coordinates 367640..367927 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag VCA1552_RS16235 Protein ID WP_001232701.1
Coordinates 367938..368255 (+) Length 106 a.a.

Genomic Context

VCA1552_RS20000VCA1552_RS16200VCA1552_RS16205VCA1552_RS16210VCA1552_RS16215VCA1552_RS16220VCA1552_RS16230VCA1552_RS16235VCA1552_RS20005VCA1552_RS16250VCA1552_RS16255VCA1552_RS16260VCA1552_RS16265VCA1552_RS16270VCA1552_RS16280VCA1552_RS16285VCA1552_RS16190VCA1552_RS16195
Location: 363276..363371 (96 bp)
Type: Others
Protein ID: WP_001907607.1
Location: 364385..364894 (510 bp)
Type: Others
Protein ID: WP_000405987.1
Location: 364951..365604 (654 bp)
Type: Others
Protein ID: WP_000226874.1
Location: 365914..366132 (219 bp)
Type: Others
Protein ID: WP_001917086.1
Location: 366535..366768 (234 bp)
Type: Others
Protein ID: WP_032482776.1
Location: 367193..367373 (181 bp)
Type: Others
Protein ID: Protein_360
Location: 367640..367927 (288 bp)
Type: Toxin
Protein ID: WP_001162670.1
Location: 367938..368255 (318 bp)
Type: Antitoxin
Protein ID: WP_001232701.1
Location: 368252..368362 (111 bp)
Type: Others
Protein ID: WP_134814058.1
Location: 368539..368664 (126 bp)
Type: Others
Protein ID: WP_001944767.1
Location: 368680..368718 (39 bp)
Type: Others
Protein ID: WP_106019119.1
Location: 368942..369682 (741 bp)
Type: Others
Protein ID: WP_000469836.1
Location: 369887..370717 (831 bp)
Type: Others
Protein ID: WP_000056616.1
Location: 370774..371256 (483 bp)
Type: Others
Protein ID: WP_001895003.1
Location: 371703..372578 (876 bp)
Type: Others
Protein ID: WP_000259044.1
Location: 372708..373163 (456 bp)
Type: Others
Protein ID: WP_001245327.1
Location: 363565..363882 (318 bp)
Type: Others
Protein ID: WP_001180243.1
Location: 363901..364143 (243 bp)
Type: Others
Protein ID: WP_000557292.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
VCA1552_RS20000363276..363371+96WP_001907607.1DUF645 family protein-
VCA1552_RS16190363565..363882-318WP_001180243.1type II toxin-antitoxin system RelE/ParE family toxin-
VCA1552_RS16195363901..364143-243WP_000557292.1type II toxin-antitoxin system Phd/YefM family antitoxin-
VCA1552_RS16200364385..364894+510WP_000405987.1GNAT family N-acetyltransferase-
VCA1552_RS16205364951..365604+654WP_000226874.1hypothetical protein-
VCA1552_RS16210365914..366132+219WP_001917086.1DUF3709 domain-containing protein-
VCA1552_RS16215366535..366768+234WP_032482776.1DUF3709 domain-containing protein-
VCA1552_RS16220367193..367373+181Protein_360DUF645 family protein-
VCA1552_RS16230367640..367927+288WP_001162670.1type II toxin-antitoxin system RelE/ParE family toxinToxin
VCA1552_RS16235367938..368255+318WP_001232701.1HigA family addiction module antidote proteinAntitoxin
VCA1552_RS20005368252..368362+111WP_134814058.1DUF3265 domain-containing protein-
VCA1552_RS16250368539..368664+126WP_001944767.1DUF645 family protein-
VCA1552_RS16255368680..368718+39WP_106019119.1hypothetical protein-
VCA1552_RS16260368942..369682+741WP_000469836.1PhzF family phenazine biosynthesis protein-
VCA1552_RS16265369887..370717+831WP_000056616.1abortive infection family protein-
VCA1552_RS16270370774..371256+483WP_001895003.1hypothetical protein-
VCA1552_RS16280371703..372578+876WP_000259044.1hypothetical protein-
VCA1552_RS16285372708..373163+456WP_001245327.1GNAT family N-acetyltransferase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-304717..433978129261
insideIntegron--309797..433602123805


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(2-95)

Antitoxin

Cro/C1-type helix-turn-helix domain

(12-69)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11349.95 Da        Isoelectric Point: 6.7187

>T88994 WP_001162670.1 NZ_CP024868:367640-367927 [Vibrio cholerae]
MALEFKDKWLEQFYEDDKRHRLIPSSIENALFRKLEILDAAQAESDLRIPPGNRFEHLEGNLKGWCSIRVNKQYRLIFQW
VDGVALNTYLDPHKY

Download         Length: 288 bp

>T88994 NZ_CP024868:367640-367927 [Vibrio cholerae]
ATGGCATTAGAATTTAAAGATAAGTGGTTAGAGCAGTTTTACGAGGATGATAAACGACATCGTTTAATTCCAAGTAGCAT
AGAGAATGCTCTATTTCGGAAGCTGGAAATCTTAGATGCAGCTCAAGCTGAATCAGACTTAAGAATTCCACCGGGTAATC
GTTTTGAACATCTTGAAGGAAATCTTAAAGGTTGGTGTTCAATTCGAGTGAACAAACAGTATCGTTTGATTTTTCAGTGG
GTTGATGGTGTTGCACTAAATACTTACTTAGACCCACATAAGTATTGA

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11705.63 Da        Isoelectric Point: 10.4711

>AT88994 WP_001232701.1 NZ_CP024868:367938-368255 [Vibrio cholerae]
MRKTKRRPVSVGEMLKVEFLEPMGITSKALAEAMGVHRNTVSNLINGGVLTAPVAIKLAAALGNTPEFWLNIQHAVDLWD
TRNRYQEEAKFVKPLFVSLEQSART

Download         Length: 318 bp

>AT88994 NZ_CP024868:367938-368255 [Vibrio cholerae]
ATGCGTAAGACAAAACGTCGTCCAGTTAGCGTTGGGGAAATGTTAAAAGTTGAATTTCTTGAACCAATGGGCATCACATC
AAAAGCGCTCGCTGAAGCGATGGGCGTACACAGAAATACGGTCAGTAATTTAATTAATGGTGGTGTGTTAACAGCTCCGG
TAGCAATCAAGTTAGCCGCGGCATTAGGTAACACACCAGAATTTTGGCTTAACATTCAACATGCAGTTGATCTTTGGGAT
ACGAGAAATCGTTATCAAGAAGAAGCAAAGTTTGTAAAGCCGTTGTTTGTTTCGCTGGAACAAAGCGCACGTACATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0F2HI36

Antitoxin

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Source
ID
Structure
No matching records found

References