Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | relBE/RelE-RelB |
Location | 343652..344211 | Replicon | chromosome |
Accession | NZ_CP028895 | ||
Organism | Vibrio cholerae strain A1552 |
Toxin (Protein)
Gene name | relE | Uniprot ID | Q9K2M8 |
Locus tag | A1552VC_RS15970 | Protein ID | WP_000578476.1 |
Coordinates | 343652..343930 (-) | Length | 93 a.a. |
Antitoxin (Protein)
Gene name | relB | Uniprot ID | Q9L991 |
Locus tag | A1552VC_RS15975 | Protein ID | WP_000381183.1 |
Coordinates | 343927..344211 (-) | Length | 95 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
A1552VC_RS15915 | 338689..338922 | + | 234 | WP_001890112.1 | DUF3709 domain-containing protein | - |
A1552VC_RS15920 | 339190..339696 | + | 507 | WP_000393074.1 | hypothetical protein | - |
A1552VC_RS15925 | 339853..340239 | + | 387 | WP_000703163.1 | VOC family protein | - |
A1552VC_RS15930 | 340434..340685 | + | 252 | WP_001890111.1 | TIGR03643 family protein | - |
A1552VC_RS15935 | 340658..340807 | + | 150 | WP_071908333.1 | DUF3265 domain-containing protein | - |
A1552VC_RS15940 | 340954..341379 | + | 426 | WP_000415750.1 | hypothetical protein | - |
A1552VC_RS15945 | 341585..342208 | + | 624 | WP_000247070.1 | DUF1349 domain-containing protein | - |
A1552VC_RS15950 | 342421..342900 | + | 480 | WP_000009888.1 | lecithin retinol acyltransferase family protein | - |
A1552VC_RS15960 | 343088..343501 | + | 414 | WP_000049420.1 | VOC family protein | - |
A1552VC_RS15970 | 343652..343930 | - | 279 | WP_000578476.1 | type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family | Toxin |
A1552VC_RS15975 | 343927..344211 | - | 285 | WP_000381183.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | Antitoxin |
A1552VC_RS15980 | 344406..344921 | + | 516 | WP_001201520.1 | lipocalin family protein | - |
A1552VC_RS15985 | 344986..345582 | + | 597 | WP_000255434.1 | hypothetical protein | - |
A1552VC_RS15995 | 345974..346156 | + | 183 | WP_000923182.1 | DUF645 family protein | - |
A1552VC_RS16000 | 346356..346829 | + | 474 | WP_001161076.1 | GrpB family protein | - |
A1552VC_RS16005 | 346844..346936 | + | 93 | WP_014378730.1 | DUF3265 domain-containing protein | - |
A1552VC_RS16010 | 346978..347604 | + | 627 | WP_000365424.1 | LysE family translocator | - |
A1552VC_RS16015 | 347727..348425 | + | 699 | WP_001890502.1 | hypothetical protein | - |
A1552VC_RS16020 | 348435..348545 | + | 111 | WP_079857360.1 | DUF3265 domain-containing protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Genomic island | catB9 | - | 306914..436175 | 129261 | |
inside | Integron | - | - | 311994..435799 | 123805 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 93 a.a. Molecular weight: 10819.59 Da Isoelectric Point: 5.1651
>T104339 WP_000578476.1 NZ_CP028895:c343930-343652 [Vibrio cholerae]
MIFWEEASLNDREKIFEFLYDFNPAAAKKTDELIEAKVENLLEQPLIGVQRDGIRGRLLIIPEISMIVSYWVDGSKIRIM
RVLHQKQKFPND
MIFWEEASLNDREKIFEFLYDFNPAAAKKTDELIEAKVENLLEQPLIGVQRDGIRGRLLIIPEISMIVSYWVDGSKIRIM
RVLHQKQKFPND
Download Length: 279 bp
>T104339 NZ_CP028895:c343930-343652 [Vibrio cholerae]
ATGATTTTCTGGGAAGAAGCATCTCTCAATGATCGTGAGAAAATTTTCGAATTTCTCTACGACTTTAACCCAGCAGCGGC
TAAAAAAACGGATGAGCTCATAGAAGCCAAAGTCGAAAATTTGCTTGAGCAACCACTAATCGGTGTTCAGCGTGATGGCA
TTAGAGGCAGATTGCTTATTATCCCTGAGATATCAATGATTGTTTCGTATTGGGTTGATGGTTCTAAAATTCGAATAATG
CGTGTACTACATCAGAAACAAAAATTTCCAAACGACTGA
ATGATTTTCTGGGAAGAAGCATCTCTCAATGATCGTGAGAAAATTTTCGAATTTCTCTACGACTTTAACCCAGCAGCGGC
TAAAAAAACGGATGAGCTCATAGAAGCCAAAGTCGAAAATTTGCTTGAGCAACCACTAATCGGTGTTCAGCGTGATGGCA
TTAGAGGCAGATTGCTTATTATCCCTGAGATATCAATGATTGTTTCGTATTGGGTTGATGGTTCTAAAATTCGAATAATG
CGTGTACTACATCAGAAACAAAAATTTCCAAACGACTGA
Antitoxin
Download Length: 95 a.a. Molecular weight: 10901.25 Da Isoelectric Point: 8.0775
>AT104339 WP_000381183.1 NZ_CP028895:c344211-343927 [Vibrio cholerae]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKALSHDAWLTEQVNQAFEKFDSGKAVFIEHDIAKAR
MAERKAKIRNRGHA
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKALSHDAWLTEQVNQAFEKFDSGKAVFIEHDIAKAR
MAERKAKIRNRGHA
Download Length: 285 bp
>AT104339 NZ_CP028895:c344211-343927 [Vibrio cholerae]
ATGGATACTAGAATTCAATTTCGTGTAGACGAAGAAACAAAACGTTTAGCTCAACAAATGGCTGAAAGCCAAGGTCGAAC
TCTTAGCGATGCTTGCCGTGAACTCACTGAACAATTAGCTGAGCAGCAACGCAAGGCATTATCTCACGATGCATGGCTAA
CTGAACAAGTGAATCAAGCATTTGAGAAGTTCGACTCAGGAAAAGCAGTATTCATTGAACATGACATCGCCAAAGCACGA
ATGGCTGAACGTAAAGCTAAAATCCGAAATCGAGGCCACGCATGA
ATGGATACTAGAATTCAATTTCGTGTAGACGAAGAAACAAAACGTTTAGCTCAACAAATGGCTGAAAGCCAAGGTCGAAC
TCTTAGCGATGCTTGCCGTGAACTCACTGAACAATTAGCTGAGCAGCAACGCAAGGCATTATCTCACGATGCATGGCTAA
CTGAACAAGTGAATCAAGCATTTGAGAAGTTCGACTCAGGAAAAGCAGTATTCATTGAACATGACATCGCCAAAGCACGA
ATGGCTGAACGTAAAGCTAAAATCCGAAATCGAGGCCACGCATGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | Q9K2M8 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A067BL33 |