Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 343652..344211 Replicon chromosome
Accession NZ_CP028895
Organism Vibrio cholerae strain A1552

Toxin (Protein)


Gene name relE Uniprot ID Q9K2M8
Locus tag A1552VC_RS15970 Protein ID WP_000578476.1
Coordinates 343652..343930 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9L991
Locus tag A1552VC_RS15975 Protein ID WP_000381183.1
Coordinates 343927..344211 (-) Length 95 a.a.

Genomic Context

A1552VC_RS15915A1552VC_RS15920A1552VC_RS15925A1552VC_RS15930A1552VC_RS15935A1552VC_RS15940A1552VC_RS15945A1552VC_RS15950A1552VC_RS15960A1552VC_RS15980A1552VC_RS15985A1552VC_RS15995A1552VC_RS16000A1552VC_RS16005A1552VC_RS16010A1552VC_RS16015A1552VC_RS16020A1552VC_RS15970A1552VC_RS15975
Location: 338689..338922 (234 bp)
Type: Others
Protein ID: WP_001890112.1
Location: 339190..339696 (507 bp)
Type: Others
Protein ID: WP_000393074.1
Location: 339853..340239 (387 bp)
Type: Others
Protein ID: WP_000703163.1
Location: 340434..340685 (252 bp)
Type: Others
Protein ID: WP_001890111.1
Location: 340658..340807 (150 bp)
Type: Others
Protein ID: WP_071908333.1
Location: 340954..341379 (426 bp)
Type: Others
Protein ID: WP_000415750.1
Location: 341585..342208 (624 bp)
Type: Others
Protein ID: WP_000247070.1
Location: 342421..342900 (480 bp)
Type: Others
Protein ID: WP_000009888.1
Location: 343088..343501 (414 bp)
Type: Others
Protein ID: WP_000049420.1
Location: 344406..344921 (516 bp)
Type: Others
Protein ID: WP_001201520.1
Location: 344986..345582 (597 bp)
Type: Others
Protein ID: WP_000255434.1
Location: 345974..346156 (183 bp)
Type: Others
Protein ID: WP_000923182.1
Location: 346356..346829 (474 bp)
Type: Others
Protein ID: WP_001161076.1
Location: 346844..346936 (93 bp)
Type: Others
Protein ID: WP_014378730.1
Location: 346978..347604 (627 bp)
Type: Others
Protein ID: WP_000365424.1
Location: 347727..348425 (699 bp)
Type: Others
Protein ID: WP_001890502.1
Location: 348435..348545 (111 bp)
Type: Others
Protein ID: WP_079857360.1
Location: 343652..343930 (279 bp)
Type: Toxin
Protein ID: WP_000578476.1
Location: 343927..344211 (285 bp)
Type: Antitoxin
Protein ID: WP_000381183.1
ToxinAntitoxinOther genes
Loading, please wait
Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
A1552VC_RS15915338689..338922+234WP_001890112.1DUF3709 domain-containing protein-
A1552VC_RS15920339190..339696+507WP_000393074.1hypothetical protein-
A1552VC_RS15925339853..340239+387WP_000703163.1VOC family protein-
A1552VC_RS15930340434..340685+252WP_001890111.1TIGR03643 family protein-
A1552VC_RS15935340658..340807+150WP_071908333.1DUF3265 domain-containing protein-
A1552VC_RS15940340954..341379+426WP_000415750.1hypothetical protein-
A1552VC_RS15945341585..342208+624WP_000247070.1DUF1349 domain-containing protein-
A1552VC_RS15950342421..342900+480WP_000009888.1lecithin retinol acyltransferase family protein-
A1552VC_RS15960343088..343501+414WP_000049420.1VOC family protein-
A1552VC_RS15970343652..343930-279WP_000578476.1type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE familyToxin
A1552VC_RS15975343927..344211-285WP_000381183.1type II toxin-antitoxin system RelB/DinJ family antitoxinAntitoxin
A1552VC_RS15980344406..344921+516WP_001201520.1lipocalin family protein-
A1552VC_RS15985344986..345582+597WP_000255434.1hypothetical protein-
A1552VC_RS15995345974..346156+183WP_000923182.1DUF645 family protein-
A1552VC_RS16000346356..346829+474WP_001161076.1GrpB family protein-
A1552VC_RS16005346844..346936+93WP_014378730.1DUF3265 domain-containing protein-
A1552VC_RS16010346978..347604+627WP_000365424.1LysE family translocator-
A1552VC_RS16015347727..348425+699WP_001890502.1hypothetical protein-
A1552VC_RS16020348435..348545+111WP_079857360.1DUF3265 domain-containing protein-

Associated MGEs

Loading, please wait
MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-306914..436175129261
insideIntegron--311994..435799123805


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-70)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10819.59 Da        Isoelectric Point: 5.1651

>T104339 WP_000578476.1 NZ_CP028895:c343930-343652 [Vibrio cholerae]
MIFWEEASLNDREKIFEFLYDFNPAAAKKTDELIEAKVENLLEQPLIGVQRDGIRGRLLIIPEISMIVSYWVDGSKIRIM
RVLHQKQKFPND

Download         Length: 279 bp

>T104339 NZ_CP028895:c343930-343652 [Vibrio cholerae]
ATGATTTTCTGGGAAGAAGCATCTCTCAATGATCGTGAGAAAATTTTCGAATTTCTCTACGACTTTAACCCAGCAGCGGC
TAAAAAAACGGATGAGCTCATAGAAGCCAAAGTCGAAAATTTGCTTGAGCAACCACTAATCGGTGTTCAGCGTGATGGCA
TTAGAGGCAGATTGCTTATTATCCCTGAGATATCAATGATTGTTTCGTATTGGGTTGATGGTTCTAAAATTCGAATAATG
CGTGTACTACATCAGAAACAAAAATTTCCAAACGACTGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10901.25 Da        Isoelectric Point: 8.0775

>AT104339 WP_000381183.1 NZ_CP028895:c344211-343927 [Vibrio cholerae]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKALSHDAWLTEQVNQAFEKFDSGKAVFIEHDIAKAR
MAERKAKIRNRGHA

Download         Length: 285 bp

>AT104339 NZ_CP028895:c344211-343927 [Vibrio cholerae]
ATGGATACTAGAATTCAATTTCGTGTAGACGAAGAAACAAAACGTTTAGCTCAACAAATGGCTGAAAGCCAAGGTCGAAC
TCTTAGCGATGCTTGCCGTGAACTCACTGAACAATTAGCTGAGCAGCAACGCAAGGCATTATCTCACGATGCATGGCTAA
CTGAACAAGTGAATCAAGCATTTGAGAAGTTCGACTCAGGAAAAGCAGTATTCATTGAACATGACATCGCCAAAGCACGA
ATGGCTGAACGTAAAGCTAAAATCCGAAATCGAGGCCACGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

Loading, please wait
Source
ID
Structure
AlphaFold DBQ9K2M8

Antitoxin

Loading, please wait
Source
ID
Structure
AlphaFold DBA0A067BL33

References