Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 358082..358697 Replicon chromosome
Accession NZ_CP012666
Organism Vibrio cholerae strain ICDC-VC661

Toxin (Protein)


Gene name higB Uniprot ID Q9KMG5
Locus tag AN947_RS01905 Protein ID WP_001162670.1
Coordinates 358082..358369 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag AN947_RS01910 Protein ID WP_001232701.1
Coordinates 358380..358697 (+) Length 106 a.a.

Genomic Context

AN947_RS20750AN947_RS01875AN947_RS01880AN947_RS01885AN947_RS01895AN947_RS01900AN947_RS01905AN947_RS01910AN947_RS20755AN947_RS01920AN947_RS20760AN947_RS01930AN947_RS01935AN947_RS01940AN947_RS01945AN947_RS01950AN947_RS01955AN947_RS01865AN947_RS01870
Location: 353718..353813 (96 bp)
Type: Others
Protein ID: WP_001907607.1
Location: 354827..355336 (510 bp)
Type: Others
Protein ID: WP_000405987.1
Location: 355393..356046 (654 bp)
Type: Others
Protein ID: WP_000226874.1
Location: 356356..356574 (219 bp)
Type: Others
Protein ID: WP_001917086.1
Location: 356977..357210 (234 bp)
Type: Others
Protein ID: WP_032482776.1
Location: 357635..357815 (181 bp)
Type: Others
Protein ID: Protein_344
Location: 358082..358369 (288 bp)
Type: Toxin
Protein ID: WP_001162670.1
Location: 358380..358697 (318 bp)
Type: Antitoxin
Protein ID: WP_001232701.1
Location: 358694..358804 (111 bp)
Type: Others
Protein ID: WP_134814058.1
Location: 358981..359106 (126 bp)
Type: Others
Protein ID: WP_001944767.1
Location: 359122..359160 (39 bp)
Type: Others
Protein ID: WP_106019119.1
Location: 359373..360377 (1005 bp)
Type: Others
Protein ID: WP_000964925.1
Location: 360530..360976 (447 bp)
Type: Others
Protein ID: WP_000128977.1
Location: 361096..362025 (930 bp)
Type: Others
Protein ID: WP_000335802.1
Location: 362022..362132 (111 bp)
Type: Others
Protein ID: WP_071917832.1
Location: 362160..362636 (477 bp)
Type: Others
Protein ID: WP_001047180.1
Location: 362773..363288 (516 bp)
Type: Others
Protein ID: WP_001201532.1
Location: 354007..354324 (318 bp)
Type: Others
Protein ID: WP_001180243.1
Location: 354343..354585 (243 bp)
Type: Others
Protein ID: WP_000557292.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
AN947_RS20750353718..353813+96WP_001907607.1DUF645 family protein-
AN947_RS01865354007..354324-318WP_001180243.1type II toxin-antitoxin system RelE/ParE family toxin-
AN947_RS01870354343..354585-243WP_000557292.1type II toxin-antitoxin system Phd/YefM family antitoxin-
AN947_RS01875354827..355336+510WP_000405987.1GNAT family N-acetyltransferase-
AN947_RS01880355393..356046+654WP_000226874.1hypothetical protein-
AN947_RS01885356356..356574+219WP_001917086.1DUF3709 domain-containing protein-
AN947_RS01895356977..357210+234WP_032482776.1DUF3709 domain-containing protein-
AN947_RS01900357635..357815+181Protein_344DUF645 family protein-
AN947_RS01905358082..358369+288WP_001162670.1type II toxin-antitoxin system RelE/ParE family toxinToxin
AN947_RS01910358380..358697+318WP_001232701.1HigA family addiction module antidote proteinAntitoxin
AN947_RS20755358694..358804+111WP_134814058.1DUF3265 domain-containing protein-
AN947_RS01920358981..359106+126WP_001944767.1DUF645 family protein-
AN947_RS20760359122..359160+39WP_106019119.1hypothetical protein-
AN947_RS01930359373..360377+1005WP_000964925.1LD-carboxypeptidase-
AN947_RS01935360530..360976+447WP_000128977.1hypothetical protein-
AN947_RS01940361096..362025+930WP_000335802.1hypothetical protein-
AN947_RS01945362022..362132+111WP_071917832.1DUF3265 domain-containing protein-
AN947_RS01950362160..362636+477WP_001047180.1GNAT family N-acetyltransferase-
AN947_RS01955362773..363288+516WP_001201532.1lipocalin family protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-304645..39989295247
insideIntegron--309725..39951689791


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(2-95)

Antitoxin

Cro/C1-type helix-turn-helix domain

(12-69)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11349.95 Da        Isoelectric Point: 6.7187

>T56915 WP_001162670.1 NZ_CP012666:358082-358369 [Vibrio cholerae]
MALEFKDKWLEQFYEDDKRHRLIPSSIENALFRKLEILDAAQAESDLRIPPGNRFEHLEGNLKGWCSIRVNKQYRLIFQW
VDGVALNTYLDPHKY

Download         Length: 288 bp

>T56915 NZ_CP012666:358082-358369 [Vibrio cholerae]
ATGGCATTAGAATTTAAAGATAAGTGGTTAGAGCAGTTTTACGAGGATGATAAACGACATCGTTTAATTCCAAGTAGCAT
AGAGAATGCTCTATTTCGGAAGCTGGAAATCTTAGATGCAGCTCAAGCTGAATCAGACTTAAGAATTCCACCGGGTAATC
GTTTTGAACATCTTGAAGGAAATCTTAAAGGTTGGTGTTCAATTCGAGTGAACAAACAGTATCGTTTGATTTTTCAGTGG
GTTGATGGTGTTGCACTAAATACTTACTTAGACCCACATAAGTATTGA

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11705.63 Da        Isoelectric Point: 10.4711

>AT56915 WP_001232701.1 NZ_CP012666:358380-358697 [Vibrio cholerae]
MRKTKRRPVSVGEMLKVEFLEPMGITSKALAEAMGVHRNTVSNLINGGVLTAPVAIKLAAALGNTPEFWLNIQHAVDLWD
TRNRYQEEAKFVKPLFVSLEQSART

Download         Length: 318 bp

>AT56915 NZ_CP012666:358380-358697 [Vibrio cholerae]
ATGCGTAAGACAAAACGTCGTCCAGTTAGCGTTGGGGAAATGTTAAAAGTTGAATTTCTTGAACCAATGGGCATCACATC
AAAAGCGCTCGCTGAAGCGATGGGCGTACACAGAAATACGGTCAGTAATTTAATTAATGGTGGTGTGTTAACAGCTCCGG
TAGCAATCAAGTTAGCCGCGGCATTAGGTAACACACCAGAATTTTGGCTTAACATTCAACATGCAGTTGATCTTTGGGAT
ACGAGAAATCGTTATCAAGAAGAAGCAAAGTTTGTAAAGCCGTTGTTTGTTTCGCTGGAACAAAGCGCACGTACATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0F2HI36

Antitoxin

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Source
ID
Structure
No matching records found

References