Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-Phd
Location 389844..390422 Replicon chromosome
Accession NZ_CP064351
Organism Vibrio cholerae C6706

Toxin (Protein)


Gene name parE Uniprot ID O68848
Locus tag IT766_RS15405 Protein ID WP_001180243.1
Coordinates 389844..390161 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q7DCR7
Locus tag IT766_RS15410 Protein ID WP_000557292.1
Coordinates 390180..390422 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IT766_RS15375 385368..385550 + 183 WP_000923340.1 DUF645 family protein -
IT766_RS15380 385904..386086 + 183 WP_000923153.1 DUF645 family protein -
IT766_RS15385 386281..386958 + 678 WP_000254617.1 HNH endonuclease -
IT766_RS15390 387120..388328 + 1209 WP_000272282.1 deoxyguanosinetriphosphate triphosphohydrolase family protein -
IT766_RS15395 388490..389194 + 705 WP_000087610.1 HNH endonuclease -
IT766_RS15400 389352..389690 + 339 WP_000713853.1 hypothetical protein -
IT766_RS15405 389844..390161 - 318 WP_001180243.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
IT766_RS15410 390180..390422 - 243 WP_000557292.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
IT766_RS15415 390666..391052 + 387 WP_001015867.1 NUDIX hydrolase -
IT766_RS15420 391109..391222 + 114 WP_001900214.1 hypothetical protein -
IT766_RS15425 391171..391452 + 282 WP_001894429.1 DUF1289 domain-containing protein -
IT766_RS15430 391710..392246 + 537 WP_000469482.1 GNAT family N-acetyltransferase -
IT766_RS15435 392383..392898 + 516 WP_001201509.1 lipocalin family protein -
IT766_RS15440 393048..393545 - 498 WP_000982260.1 GNAT family N-acetyltransferase -
IT766_RS15445 393542..393814 - 273 WP_000246253.1 DUF1778 domain-containing protein -
IT766_RS15450 394207..394332 + 126 WP_001900195.1 DUF645 family protein -
IT766_RS15455 394348..394386 + 39 WP_106019118.1 hypothetical protein -
IT766_RS15460 394582..395028 + 447 WP_000006157.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 373204..502464 129260
inside Integron - - 378284..502088 123804


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-93)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-71)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12158.97 Da        Isoelectric Point: 9.7495

>T180865 WP_001180243.1 NZ_CP064351:c390161-389844 [Vibrio cholerae C6706]
MQNKQYKLSQLAQEHLLKIKHYTIENFAEAQWQKYKSTLLSGFQTLADNPGLGKSCEDIYQNGFYFPVGKHMAYYTKEAN
FILIVAVLGQSQLPQKHLKQSRFVS

Download         Length: 318 bp

>T180865 NZ_CP085763:114939-115424 [Enterobacter hormaechei]
GTGGGACGTGTAACAGCACCAGAACCATTATCCAGCTCCCATCAACTAGCAGAGTTCGTCAGTGGTGAGGCAGTACTTGA
TGACTGGCTTAAACAGAGGGGATTAAAAAACCAAGCTCTTGGTGCAGCACGAACGTTCGTCGTTTGTAAAAGAGACACTA
AACAGGTTGTCGGTTTTTACTCTCTGGCCACCGGCAGCGTTAACCACGTGGAAGCAATGGGAAGCCTCAGGCGCAATATG
CCAGATCCAATTCCCGTAATCATACTTGCTCGCCTGGCAGTTGATGTTTCATACCGTGGCCAAGGGCTCGGGGCCGATTT
ACTGCATGATGCAGTTCTGCGCTGTTACCGTGTAGCTGAGAATATTGGAGTCCGTGCGATTATGGTTCATGCACTGACTG
AAGAAGCCAAAAACTTTTATCTTCACCATGGCTTTAAGGCATCACAAACTCAGGAACGGACATTGTTTTTAAAGTTACCA
CAGTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.25 Da        Isoelectric Point: 5.6630

>AT180865 WP_000557292.1 NZ_CP064351:c390422-390180 [Vibrio cholerae C6706]
MHTLTANDAKRNFGELLLSAQREPVIISKNSKNTVVVMSIKDFEELEAMKLDYLKHCFESAQKDLDSGKTVDGATFLNTL

Download         Length: 243 bp

>AT180865 NZ_CP085763:114685-114951 [Enterobacter hormaechei]
ATGAAATCAGATGTTCAGCTCAACCTTAGAGCTAAAGAATCTCAAAGAGCACTTATTGATGCTGCAGCAGAGATTCTCCA
TAAATCACGCACGGACTTCATCCTGGAAATGGCATGTCAGGCTGCGGAGAATGTGATCCTCGATCGTCGCGTATTTAATT
TTAACGATGAGCAGTATGCAGAGTTTATCGATATGCTCGATGCACCGGTTTCGGATGAGGCGGCTATTGATAAACTTCTG
GCAAGGAAACCTCAGTGGGACGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0K9UJR8

Antitoxin

Source ID Structure
AlphaFold DB Q7DCR7

References