Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 388415..388974 Replicon chromosome
Accession NZ_OW443148
Organism Vibrio cholerae strain CNRVC190243 isolate YE-NCPHL-19014-PI

Toxin (Protein)


Gene name relE Uniprot ID Q9K2M8
Locus tag OC617_RS15720 Protein ID WP_000578476.1
Coordinates 388415..388693 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9L991
Locus tag OC617_RS15725 Protein ID WP_000381183.1
Coordinates 388690..388974 (-) Length 95 a.a.

Genomic Context

OC617_RS15670OC617_RS15675OC617_RS15680OC617_RS15685OC617_RS15690OC617_RS15695OC617_RS15700OC617_RS15705OC617_RS15710OC617_RS15715OC617_RS15730OC617_RS15735OC617_RS15740OC617_RS15745OC617_RS15750OC617_RS15755OC617_RS15760OC617_RS15765OC617_RS15770OC617_RS15720OC617_RS15725
Location: 383493..383999 (507 bp)
Type: Others
Protein ID: WP_000393074.1
Location: 384156..384542 (387 bp)
Type: Others
Protein ID: WP_000703163.1
Location: 384799..385002 (204 bp)
Type: Others
Protein ID: WP_001911580.1
Location: 385197..385448 (252 bp)
Type: Others
Protein ID: WP_001890111.1
Location: 385421..385570 (150 bp)
Type: Others
Protein ID: WP_071908333.1
Location: 385717..386142 (426 bp)
Type: Others
Protein ID: WP_000415750.1
Location: 386348..386971 (624 bp)
Type: Others
Protein ID: WP_000247070.1
Location: 387184..387663 (480 bp)
Type: Others
Protein ID: WP_000009888.1
Location: 387660..387776 (117 bp)
Type: Others
Protein ID: WP_086010882.1
Location: 387851..388264 (414 bp)
Type: Others
Protein ID: WP_000049420.1
Location: 389223..389684 (462 bp)
Type: Others
Protein ID: WP_001911578.1
Location: 389749..390345 (597 bp)
Type: Others
Protein ID: WP_000255434.1
Location: 390539..390676 (138 bp)
Type: Others
Protein ID: WP_001890145.1
Location: 390737..390919 (183 bp)
Type: Others
Protein ID: WP_000923182.1
Location: 391119..391592 (474 bp)
Type: Others
Protein ID: WP_001161076.1
Location: 391607..391699 (93 bp)
Type: Others
Protein ID: WP_014378730.1
Location: 391741..392367 (627 bp)
Type: Others
Protein ID: WP_000365424.1
Location: 392490..393188 (699 bp)
Type: Others
Protein ID: WP_001890502.1
Location: 393219..393308 (90 bp)
Type: Others
Protein ID: WP_072606010.1
Location: 388415..388693 (279 bp)
Type: Toxin
Protein ID: WP_000578476.1
Location: 388690..388974 (285 bp)
Type: Antitoxin
Protein ID: WP_000381183.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
OC617_RS15670 (CNRVC190243H_03103)383493..383999+507WP_000393074.1hypothetical protein-
OC617_RS15675 (CNRVC190243H_03104)384156..384542+387WP_000703163.1VOC family protein-
OC617_RS15680 (CNRVC190243H_03105)384799..385002+204WP_001911580.1hypothetical protein-
OC617_RS15685 (CNRVC190243H_03106)385197..385448+252WP_001890111.1TIGR03643 family protein-
OC617_RS15690385421..385570+150WP_071908333.1DUF3265 domain-containing protein-
OC617_RS15695 (CNRVC190243H_03107)385717..386142+426WP_000415750.1hypothetical protein-
OC617_RS15700 (CNRVC190243H_03108)386348..386971+624WP_000247070.1DUF1349 domain-containing protein-
OC617_RS15705 (CNRVC190243H_03109)387184..387663+480WP_000009888.1lecithin retinol acyltransferase family protein-
OC617_RS15710387660..387776+117WP_086010882.1DUF3265 domain-containing protein-
OC617_RS15715 (CNRVC190243H_03110)387851..388264+414WP_000049420.1VOC family protein-
OC617_RS15720 (CNRVC190243H_03111)388415..388693-279WP_000578476.1type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE familyToxin
OC617_RS15725 (CNRVC190243H_03112)388690..388974-285WP_000381183.1type II toxin-antitoxin system RelB/DinJ family antitoxinAntitoxin
OC617_RS15730 (CNRVC190243H_03113)389223..389684+462WP_001911578.1lipocalin family protein-
OC617_RS15735 (CNRVC190243H_03114)389749..390345+597WP_000255434.1hypothetical protein-
OC617_RS15740390539..390676+138WP_001890145.1hypothetical protein-
OC617_RS15745390737..390919+183WP_000923182.1DUF645 family protein-
OC617_RS15750 (CNRVC190243H_03115)391119..391592+474WP_001161076.1GrpB family protein-
OC617_RS15755391607..391699+93WP_014378730.1DUF3265 domain-containing protein-
OC617_RS15760 (CNRVC190243H_03116)391741..392367+627WP_000365424.1LysE family translocator-
OC617_RS15765 (CNRVC190243H_03117)392490..393188+699WP_001890502.1hypothetical protein-
OC617_RS15770393219..393308+90WP_072606010.1DUF3265 domain-containing protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-349905..456410106505
insideIntegroncatB9-354985..456034101049


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-70)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10819.59 Da        Isoelectric Point: 5.1651

>T295390 WP_000578476.1 NZ_OW443148:c388693-388415 [Vibrio cholerae]
MIFWEEASLNDREKIFEFLYDFNPAAAKKTDELIEAKVENLLEQPLIGVQRDGIRGRLLIIPEISMIVSYWVDGSKIRIM
RVLHQKQKFPND

Download         Length: 279 bp

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10901.25 Da        Isoelectric Point: 8.0775

>AT295390 WP_000381183.1 NZ_OW443148:c388974-388690 [Vibrio cholerae]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKALSHDAWLTEQVNQAFEKFDSGKAVFIEHDIAKAR
MAERKAKIRNRGHA

Download         Length: 285 bp


Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBQ9K2M8

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A067BL33

References