Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /BrnT(toxin)
Location 331975..332473 Replicon chromosome
Accession NZ_CP025937
Organism Vibrio cholerae strain A1552

Toxin (Protein)


Gene name - Uniprot ID Q9KMK7
Locus tag C1H56_RS15840 Protein ID WP_000589156.1
Coordinates 331975..332241 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q9KMK6
Locus tag C1H56_RS15845 Protein ID WP_000643598.1
Coordinates 332228..332473 (+) Length 82 a.a.

Genomic Context

C1H56_RS19835C1H56_RS15785C1H56_RS15790C1H56_RS15795C1H56_RS15800C1H56_RS15805C1H56_RS15810C1H56_RS19945C1H56_RS19950C1H56_RS15825C1H56_RS15830C1H56_RS15840C1H56_RS15845C1H56_RS15850C1H56_RS19955C1H56_RS15865C1H56_RS15870C1H56_RS15875C1H56_RS15880C1H56_RS15885C1H56_RS15890
Location: 327395..327601 (207 bp)
Type: Others
Protein ID: Protein_290
Location: 327801..327902 (102 bp)
Type: Others
Protein ID: WP_001921603.1
Location: 327892..328278 (387 bp)
Type: Others
Protein ID: WP_000703163.1
Location: 328473..328724 (252 bp)
Type: Others
Protein ID: WP_001890111.1
Location: 328697..328846 (150 bp)
Type: Others
Protein ID: WP_071908333.1
Location: 328938..329180 (243 bp)
Type: Others
Protein ID: WP_000107461.1
Location: 329387..329710 (324 bp)
Type: Others
Protein ID: WP_001890134.1
Location: 330085..330228 (144 bp)
Type: Others
Protein ID: Protein_297
Location: 330282..330320 (39 bp)
Type: Others
Protein ID: WP_082798268.1
Location: 330532..330999 (468 bp)
Type: Others
Protein ID: WP_001289288.1
Location: 331127..331790 (664 bp)
Type: Others
Protein ID: Protein_300
Location: 331975..332241 (267 bp)
Type: Toxin
Protein ID: WP_000589156.1
Location: 332228..332473 (246 bp)
Type: Antitoxin
Protein ID: WP_000643598.1
Location: 332569..333363 (795 bp)
Type: Others
Protein ID: WP_001911581.1
Location: 333466..333594 (129 bp)
Type: Others
Protein ID: WP_071908338.1
Location: 333655..333837 (183 bp)
Type: Others
Protein ID: WP_000923182.1
Location: 334053..335057 (1005 bp)
Type: Others
Protein ID: WP_000964920.1
Location: 335210..335569 (360 bp)
Type: Others
Protein ID: WP_001071541.1
Location: 335842..336075 (234 bp)
Type: Others
Protein ID: WP_001890112.1
Location: 336343..336849 (507 bp)
Type: Others
Protein ID: WP_000393074.1
Location: 337006..337392 (387 bp)
Type: Others
Protein ID: WP_000703163.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
C1H56_RS19835327395..327601+207Protein_290DUF3709 domain-containing protein-
C1H56_RS15785327801..327902+102WP_001921603.1hypothetical protein-
C1H56_RS15790327892..328278+387WP_000703163.1VOC family protein-
C1H56_RS15795328473..328724+252WP_001890111.1TIGR03643 family protein-
C1H56_RS15800328697..328846+150WP_071908333.1DUF3265 domain-containing protein-
C1H56_RS15805328938..329180+243WP_000107461.1hypothetical protein-
C1H56_RS15810329387..329710+324WP_001890134.1DUF3709 domain-containing protein-
C1H56_RS19945330085..330228+144Protein_297DUF645 family protein-
C1H56_RS19950330282..330320+39WP_082798268.1hypothetical protein-
C1H56_RS15825330532..330999+468WP_001289288.1OsmC family protein-
C1H56_RS15830331127..331790+664Protein_300hypothetical protein-
C1H56_RS15840331975..332241+267WP_000589156.1BrnT family toxinToxin
C1H56_RS15845332228..332473+246WP_000643598.1hypothetical proteinAntitoxin
C1H56_RS15850332569..333363+795WP_001911581.1hypothetical protein-
C1H56_RS19955333466..333594+129WP_071908338.1general secretion pathway protein GspI-
C1H56_RS15865333655..333837+183WP_000923182.1DUF645 family protein-
C1H56_RS15870334053..335057+1005WP_000964920.1LD-carboxypeptidase-
C1H56_RS15875335210..335569+360WP_001071541.1VOC family protein-
C1H56_RS15880335842..336075+234WP_001890112.1DUF3709 domain-containing protein-
C1H56_RS15885336343..336849+507WP_000393074.1hypothetical protein-
C1H56_RS15890337006..337392+387WP_000703163.1VOC family protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-304067..433328129261
insideIntegroncatB9-309147..432952123805


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(6-81)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10092.34 Da        Isoelectric Point: 7.3171

>T92505 WP_000589156.1 NZ_CP025937:331975-332241 [Vibrio cholerae]
MIKFEFDENKSRSNLEKHGIDFHTAQGLWNDSDLIEIPANTSDEPRYLVVGLLNGKHWSGVITYRGTNIRIISVRRSRKA
EVSLYESA

Download         Length: 267 bp

>T92505 NZ_CP025937:331975-332241 [Vibrio cholerae]
ATGATTAAATTTGAATTTGATGAAAACAAAAGCAGAAGTAATCTCGAAAAGCACGGTATTGATTTTCATACAGCTCAAGG
ATTGTGGAATGATTCAGATCTTATCGAGATCCCTGCTAACACGAGTGATGAGCCCAGATATTTGGTTGTCGGCTTACTAA
ACGGTAAGCATTGGTCAGGAGTAATTACCTACCGAGGTACGAATATCAGGATCATCTCAGTTCGGCGTTCACGGAAAGCG
GAGGTAAGCCTTTATGAAAGCGCATGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9478.77 Da        Isoelectric Point: 6.4832

>AT92505 WP_000643598.1 NZ_CP025937:332228-332473 [Vibrio cholerae]
MKAHEFDAKFESDDDDIVMDLDLSQAKRPMHKQKRVNVDFPAWMLESLDREASRIGVTRQSIIKIWLAERLESVSHHSSV
R

Download         Length: 246 bp

>AT92505 NZ_CP025937:332228-332473 [Vibrio cholerae]
ATGAAAGCGCATGAATTTGATGCCAAGTTTGAAAGTGACGACGATGATATCGTAATGGACTTGGATCTATCGCAAGCTAA
AAGACCGATGCATAAGCAAAAACGAGTCAATGTAGATTTTCCAGCCTGGATGCTTGAGTCCTTGGACAGAGAAGCGAGTC
GTATTGGTGTAACACGTCAATCAATCATTAAAATTTGGCTGGCAGAAAGGTTAGAGAGCGTGTCTCATCATTCAAGTGTG
AGATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A271VMP7

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A271VME2

References