Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-Phd
Location 321274..321852 Replicon chromosome
Accession NZ_CP090379
Organism Vibrio cholerae strain BY369

Toxin (Protein)


Gene name parE Uniprot ID O68848
Locus tag LVJ30_RS15220 Protein ID WP_001180243.1
Coordinates 321274..321591 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q7DCR7
Locus tag LVJ30_RS15225 Protein ID WP_000557292.1
Coordinates 321610..321852 (-) Length 81 a.a.

Genomic Context

LVJ30_RS15185LVJ30_RS15190LVJ30_RS15195LVJ30_RS15200LVJ30_RS15205LVJ30_RS15210LVJ30_RS15215LVJ30_RS15230LVJ30_RS15235LVJ30_RS15240LVJ30_RS15245LVJ30_RS15250LVJ30_RS15255LVJ30_RS15270LVJ30_RS15275LVJ30_RS15220LVJ30_RS15225LVJ30_RS15260LVJ30_RS15265
Location: 316809..316991 (183 bp)
Type: Others
Protein ID: WP_000923340.1
Location: 317111..317173 (63 bp)
Type: Others
Protein ID: Protein_271
Location: 317345..317527 (183 bp)
Type: Others
Protein ID: WP_000923153.1
Location: 317722..318399 (678 bp)
Type: Others
Protein ID: WP_000254617.1
Location: 318561..319758 (1198 bp)
Type: Others
Protein ID: Protein_274
Location: 319920..320624 (705 bp)
Type: Others
Protein ID: WP_000087610.1
Location: 320782..321120 (339 bp)
Type: Others
Protein ID: WP_000713853.1
Location: 322096..322482 (387 bp)
Type: Others
Protein ID: WP_001015867.1
Location: 322539..322652 (114 bp)
Type: Others
Protein ID: WP_001900214.1
Location: 322661..322882 (222 bp)
Type: Others
Protein ID: WP_032467793.1
Location: 323140..323676 (537 bp)
Type: Others
Protein ID: WP_000469482.1
Location: 323867..324328 (462 bp)
Type: Others
Protein ID: WP_001903091.1
Location: 324393..324461 (69 bp)
Type: Others
Protein ID: Protein_284
Location: 325637..325762 (126 bp)
Type: Others
Protein ID: WP_001900195.1
Location: 326012..326458 (447 bp)
Type: Others
Protein ID: WP_000006157.1
Location: 321274..321591 (318 bp)
Type: Toxin
Protein ID: WP_001180243.1
Location: 321610..321852 (243 bp)
Type: Antitoxin
Protein ID: WP_000557292.1
Location: 324478..324975 (498 bp)
Type: Others
Protein ID: WP_000982260.1
Location: 324972..325244 (273 bp)
Type: Others
Protein ID: WP_000246253.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
LVJ30_RS15185 (LVJ30_15190)316809..316991+183WP_000923340.1DUF645 family protein-
LVJ30_RS15190 (LVJ30_15195)317111..317173+63Protein_271acetyltransferase-
LVJ30_RS15195 (LVJ30_15200)317345..317527+183WP_000923153.1DUF645 family protein-
LVJ30_RS15200 (LVJ30_15205)317722..318399+678WP_000254617.1HNH endonuclease signature motif containing protein-
LVJ30_RS15205 (LVJ30_15210)318561..319758+1198Protein_274deoxyguanosinetriphosphate triphosphohydrolase family protein-
LVJ30_RS15210 (LVJ30_15215)319920..320624+705WP_000087610.1HNH endonuclease-
LVJ30_RS15215 (LVJ30_15220)320782..321120+339WP_000713853.1hypothetical protein-
LVJ30_RS15220 (LVJ30_15225)321274..321591-318WP_001180243.1type II toxin-antitoxin system RelE/ParE family toxinToxin
LVJ30_RS15225 (LVJ30_15230)321610..321852-243WP_000557292.1type II toxin-antitoxin system Phd/YefM family antitoxinAntitoxin
LVJ30_RS15230 (LVJ30_15235)322096..322482+387WP_001015867.1NUDIX hydrolase-
LVJ30_RS15235 (LVJ30_15240)322539..322652+114WP_001900214.1hypothetical protein-
LVJ30_RS15240 (LVJ30_15245)322661..322882+222WP_032467793.1DUF1289 domain-containing protein-
LVJ30_RS15245 (LVJ30_15250)323140..323676+537WP_000469482.1GNAT family protein-
LVJ30_RS15250 (LVJ30_15255)323867..324328+462WP_001903091.1lipocalin family protein-
LVJ30_RS15255 (LVJ30_15260)324393..324461+69Protein_284acetyltransferase-
LVJ30_RS15260 (LVJ30_15265)324478..324975-498WP_000982260.1GNAT family N-acetyltransferase-
LVJ30_RS15265 (LVJ30_15270)324972..325244-273WP_000246253.1DUF1778 domain-containing protein-
LVJ30_RS15270 (LVJ30_15275)325637..325762+126WP_001900195.1DUF645 family protein-
LVJ30_RS15275 (LVJ30_15280)326012..326458+447WP_000006157.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-304645..39989295247
insideIntegron--309725..39951689791


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-93)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-71)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12158.97 Da        Isoelectric Point: 9.7495

>T230515 WP_001180243.1 NZ_CP090379:c321591-321274 [Vibrio cholerae]
MQNKQYKLSQLAQEHLLKIKHYTIENFAEAQWQKYKSTLLSGFQTLADNPGLGKSCEDIYQNGFYFPVGKHMAYYTKEAN
FILIVAVLGQSQLPQKHLKQSRFVS

Download         Length: 318 bp

>T230515 NZ_CP124916:c311460-311365 [Enterococcus faecalis]
ATGTACGAGATTGTCACAAAAGTTCTTGTGCCGATTTTTGTCGGGATTGTCCTGAAACTTGTAACCATTTGGTTGGAAAA
ACAGAACGAGGAATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.25 Da        Isoelectric Point: 5.6630

>AT230515 WP_000557292.1 NZ_CP090379:c321852-321610 [Vibrio cholerae]
MHTLTANDAKRNFGELLLSAQREPVIISKNSKNTVVVMSIKDFEELEAMKLDYLKHCFESAQKDLDSGKTVDGATFLNTL

Download         Length: 243 bp

>AT230515 NZ_CP124916:311266-311330 [Enterococcus faecalis]
CTTGTGACAAAGTCGTGCATGGATGCACTAAAAAGACACCCTATTGCGGTAGGGTGTCTTTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0K9UJR8

Antitoxin

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Source
ID
Structure
AlphaFold DBQ7DCR7

References