Detailed information of TA system TA125039

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /BrnT(toxin)
• Location: 910495..910993
• Replicon: chromosome
• Accession: NZ_CP040173
• Organism: Vibrio cholerae strain VC1374

Toxin (Protein)

• Gene name: -
• Uniprot ID: Q9KMK7
• Locus tag: FDZ90_RS18770
• Protein ID: WP_000589156.1
• Coordinates: 910495..910761 (+)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: Q9KMK6
• Locus tag: FDZ90_RS18775
• Protein ID: WP_000643598.1
• Coordinates: 910748..910993 (+)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FDZ90_RS18715	905916..906122	+	207	Protein_796	DUF3709 domain-containing protein	-
FDZ90_RS18720	906322..906423	+	102	WP_001921603.1	hypothetical protein	-
FDZ90_RS18725	906413..906799	+	387	WP_000703163.1	VOC family protein	-
FDZ90_RS18730	906994..907245	+	252	WP_001890111.1	TIGR03643 family protein	-
FDZ90_RS18735	907218..907367	+	150	WP_071908333.1	DUF3265 domain-containing protein	-
FDZ90_RS18740	907459..907701	+	243	WP_000107461.1	hypothetical protein	-
FDZ90_RS18745	907953..908231	+	279	WP_000280324.1	DUF3709 domain-containing protein	-
FDZ90_RS18750	908606..908749	+	144	Protein_803	DUF645 family protein	-
FDZ90_RS18755	908803..908841	+	39	WP_082798268.1	hypothetical protein	-
FDZ90_RS18760	909053..909520	+	468	WP_001289288.1	OsmC family protein	-
FDZ90_RS18765	909648..910310	+	663	WP_000960654.1	hypothetical protein	-
FDZ90_RS18770	910495..910761	+	267	WP_000589156.1	BrnT family toxin	Toxin
FDZ90_RS18775	910748..910993	+	246	WP_000643598.1	hypothetical protein	Antitoxin
FDZ90_RS18780	911089..911883	+	795	WP_001911581.1	hypothetical protein	-
FDZ90_RS18785	911986..912114	+	129	WP_071908338.1	general secretion pathway protein GspI	-
FDZ90_RS18790	912175..912357	+	183	WP_000923182.1	DUF645 family protein	-
FDZ90_RS18795	912557..913030	+	474	WP_001161076.1	GrpB family protein	-
FDZ90_RS18800	913027..913137	+	111	WP_071908312.1	DUF3265 domain-containing protein	-
FDZ90_RS18805	913179..913805	+	627	WP_000365424.1	LysE family translocator	-
FDZ90_RS18810	913928..914626	+	699	WP_001890502.1	hypothetical protein	-
FDZ90_RS18815	914630..914746	+	117	WP_071908339.1	DUF3265 domain-containing protein	-
FDZ90_RS18820	915324..915503	+	180	WP_001883058.1	DUF645 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	catB9	-	882589..977840	95251
	Similar MGE(s) Similar MGE(s) is defined as other TA-related MGE(s) with Mash distance < 0.01 to this MGE. Detail Genome accession Organism MGE type Related TA Coordinates Mash distance View NC_002506 Vibrio cholerae O1 biovar El Tor str. N16961 Integron TA000164, TA000169, TA000166, TA000167, TA000179, TA000170, TA000171, TA000172, TA000173, TA000174, TA000175, TA000176, TA000177, TA000178, TA000168, TA000165, TA010030, TA010035 309750..435387 0.005	inside	Integron	catB9	-	887669..977464	89795

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Ribonuclease toxin, BrnT, of type II toxin-antitoxin system (6-81)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10092.34 Da
• Isoelectric Point: 7.3171

>T125039 WP_000589156.1 NZ_CP040173:910495-910761 [Vibrio cholerae]
MIKFEFDENKSRSNLEKHGIDFHTAQGLWNDSDLIEIPANTSDEPRYLVVGLLNGKHWSGVITYRGTNIRIISVRRSRKA
EVSLYESA

Nucleotide

• Length: 267 bp

>T125039 NZ_CP040173:910495-910761 [Vibrio cholerae]
ATGATTAAATTTGAATTTGATGAAAACAAAAGCAGAAGTAATCTCGAAAAGCACGGTATTGATTTTCATACAGCTCAAGG
ATTGTGGAATGATTCAGATCTTATCGAGATCCCTGCTAACACGAGTGATGAGCCCAGATATTTGGTTGTCGGCTTACTAA
ACGGTAAGCATTGGTCAGGAGTAATTACCTACCGAGGTACGAATATCAGGATCATCTCAGTTCGGCGTTCACGGAAAGCG
GAGGTAAGCCTTTATGAAAGCGCATGA

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 9478.77 Da
• Isoelectric Point: 6.4832

>AT125039 WP_000643598.1 NZ_CP040173:910748-910993 [Vibrio cholerae]
MKAHEFDAKFESDDDDIVMDLDLSQAKRPMHKQKRVNVDFPAWMLESLDREASRIGVTRQSIIKIWLAERLESVSHHSSV
R

Nucleotide

• Length: 246 bp

>AT125039 NZ_CP040173:910748-910993 [Vibrio cholerae]
ATGAAAGCGCATGAATTTGATGCCAAGTTTGAAAGTGACGACGATGATATCGTAATGGACTTGGATCTATCGCAAGCTAA
AAGACCGATGCATAAGCAAAAACGAGTCAATGTAGATTTTCCAGCCTGGATGCTTGAGTCCTTGGACAGAGAAGCGAGTC
GTATTGGTGTAACACGTCAATCAATCATTAAAATTTGGCTGGCAGAAAGGTTAGAGAGCGTGTCTCATCATTCAAGTGTG
AGATAA

Structures

Toxin

• AlphaFold DB: A0A271VMP7

Antitoxin

• AlphaFold DB: A0A271VME2