Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /BrnT(toxin)
Location 910495..910993 Replicon chromosome
Accession NZ_CP040173
Organism Vibrio cholerae strain VC1374

Toxin (Protein)


Gene name - Uniprot ID Q9KMK7
Locus tag FDZ90_RS18770 Protein ID WP_000589156.1
Coordinates 910495..910761 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q9KMK6
Locus tag FDZ90_RS18775 Protein ID WP_000643598.1
Coordinates 910748..910993 (+) Length 82 a.a.

Genomic Context

FDZ90_RS18715FDZ90_RS18720FDZ90_RS18725FDZ90_RS18730FDZ90_RS18735FDZ90_RS18740FDZ90_RS18745FDZ90_RS18750FDZ90_RS18755FDZ90_RS18760FDZ90_RS18765FDZ90_RS18770FDZ90_RS18775FDZ90_RS18780FDZ90_RS18785FDZ90_RS18790FDZ90_RS18795FDZ90_RS18800FDZ90_RS18805FDZ90_RS18810FDZ90_RS18815FDZ90_RS18820
Location: 905916..906122 (207 bp)
Type: Others
Protein ID: Protein_796
Location: 906322..906423 (102 bp)
Type: Others
Protein ID: WP_001921603.1
Location: 906413..906799 (387 bp)
Type: Others
Protein ID: WP_000703163.1
Location: 906994..907245 (252 bp)
Type: Others
Protein ID: WP_001890111.1
Location: 907218..907367 (150 bp)
Type: Others
Protein ID: WP_071908333.1
Location: 907459..907701 (243 bp)
Type: Others
Protein ID: WP_000107461.1
Location: 907953..908231 (279 bp)
Type: Others
Protein ID: WP_000280324.1
Location: 908606..908749 (144 bp)
Type: Others
Protein ID: Protein_803
Location: 908803..908841 (39 bp)
Type: Others
Protein ID: WP_082798268.1
Location: 909053..909520 (468 bp)
Type: Others
Protein ID: WP_001289288.1
Location: 909648..910310 (663 bp)
Type: Others
Protein ID: WP_000960654.1
Location: 910495..910761 (267 bp)
Type: Toxin
Protein ID: WP_000589156.1
Location: 910748..910993 (246 bp)
Type: Antitoxin
Protein ID: WP_000643598.1
Location: 911089..911883 (795 bp)
Type: Others
Protein ID: WP_001911581.1
Location: 911986..912114 (129 bp)
Type: Others
Protein ID: WP_071908338.1
Location: 912175..912357 (183 bp)
Type: Others
Protein ID: WP_000923182.1
Location: 912557..913030 (474 bp)
Type: Others
Protein ID: WP_001161076.1
Location: 913027..913137 (111 bp)
Type: Others
Protein ID: WP_071908312.1
Location: 913179..913805 (627 bp)
Type: Others
Protein ID: WP_000365424.1
Location: 913928..914626 (699 bp)
Type: Others
Protein ID: WP_001890502.1
Location: 914630..914746 (117 bp)
Type: Others
Protein ID: WP_071908339.1
Location: 915324..915503 (180 bp)
Type: Others
Protein ID: WP_001883058.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
FDZ90_RS18715905916..906122+207Protein_796DUF3709 domain-containing protein-
FDZ90_RS18720906322..906423+102WP_001921603.1hypothetical protein-
FDZ90_RS18725906413..906799+387WP_000703163.1VOC family protein-
FDZ90_RS18730906994..907245+252WP_001890111.1TIGR03643 family protein-
FDZ90_RS18735907218..907367+150WP_071908333.1DUF3265 domain-containing protein-
FDZ90_RS18740907459..907701+243WP_000107461.1hypothetical protein-
FDZ90_RS18745907953..908231+279WP_000280324.1DUF3709 domain-containing protein-
FDZ90_RS18750908606..908749+144Protein_803DUF645 family protein-
FDZ90_RS18755908803..908841+39WP_082798268.1hypothetical protein-
FDZ90_RS18760909053..909520+468WP_001289288.1OsmC family protein-
FDZ90_RS18765909648..910310+663WP_000960654.1hypothetical protein-
FDZ90_RS18770910495..910761+267WP_000589156.1BrnT family toxinToxin
FDZ90_RS18775910748..910993+246WP_000643598.1hypothetical proteinAntitoxin
FDZ90_RS18780911089..911883+795WP_001911581.1hypothetical protein-
FDZ90_RS18785911986..912114+129WP_071908338.1general secretion pathway protein GspI-
FDZ90_RS18790912175..912357+183WP_000923182.1DUF645 family protein-
FDZ90_RS18795912557..913030+474WP_001161076.1GrpB family protein-
FDZ90_RS18800913027..913137+111WP_071908312.1DUF3265 domain-containing protein-
FDZ90_RS18805913179..913805+627WP_000365424.1LysE family translocator-
FDZ90_RS18810913928..914626+699WP_001890502.1hypothetical protein-
FDZ90_RS18815914630..914746+117WP_071908339.1DUF3265 domain-containing protein-
FDZ90_RS18820915324..915503+180WP_001883058.1DUF645 family protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-882589..97784095251
insideIntegroncatB9-887669..97746489795


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(6-81)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10092.34 Da        Isoelectric Point: 7.3171

>T125039 WP_000589156.1 NZ_CP040173:910495-910761 [Vibrio cholerae]
MIKFEFDENKSRSNLEKHGIDFHTAQGLWNDSDLIEIPANTSDEPRYLVVGLLNGKHWSGVITYRGTNIRIISVRRSRKA
EVSLYESA

Download         Length: 267 bp

>T125039 NZ_CP040173:910495-910761 [Vibrio cholerae]
ATGATTAAATTTGAATTTGATGAAAACAAAAGCAGAAGTAATCTCGAAAAGCACGGTATTGATTTTCATACAGCTCAAGG
ATTGTGGAATGATTCAGATCTTATCGAGATCCCTGCTAACACGAGTGATGAGCCCAGATATTTGGTTGTCGGCTTACTAA
ACGGTAAGCATTGGTCAGGAGTAATTACCTACCGAGGTACGAATATCAGGATCATCTCAGTTCGGCGTTCACGGAAAGCG
GAGGTAAGCCTTTATGAAAGCGCATGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9478.77 Da        Isoelectric Point: 6.4832

>AT125039 WP_000643598.1 NZ_CP040173:910748-910993 [Vibrio cholerae]
MKAHEFDAKFESDDDDIVMDLDLSQAKRPMHKQKRVNVDFPAWMLESLDREASRIGVTRQSIIKIWLAERLESVSHHSSV
R

Download         Length: 246 bp

>AT125039 NZ_CP040173:910748-910993 [Vibrio cholerae]
ATGAAAGCGCATGAATTTGATGCCAAGTTTGAAAGTGACGACGATGATATCGTAATGGACTTGGATCTATCGCAAGCTAA
AAGACCGATGCATAAGCAAAAACGAGTCAATGTAGATTTTCCAGCCTGGATGCTTGAGTCCTTGGACAGAGAAGCGAGTC
GTATTGGTGTAACACGTCAATCAATCATTAAAATTTGGCTGGCAGAAAGGTTAGAGAGCGTGTCTCATCATTCAAGTGTG
AGATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A271VMP7

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A271VME2

References