Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 54322..54862 Replicon chromosome
Accession NZ_CP007635
Organism Vibrio cholerae strain 2012EL-2176

Toxin (Protein)


Gene name relE Uniprot ID A0A151JGK8
Locus tag EN18_RS14435 Protein ID WP_000277238.1
Coordinates 54322..54591 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9KML3
Locus tag EN18_RS14440 Protein ID WP_001258569.1
Coordinates 54584..54862 (-) Length 93 a.a.

Genomic Context

EN18_RS14395EN18_RS14400EN18_RS21085EN18_RS21090EN18_RS14425EN18_RS14430EN18_RS20510EN18_RS21105EN18_RS21110EN18_RS14450EN18_RS14455EN18_RS20520EN18_RS14460EN18_RS14465EN18_RS21540EN18_RS21545EN18_RS14475EN18_RS14405EN18_RS14410EN18_RS14435EN18_RS14440
Location: 49543..50079 (537 bp)
Type: Others
Protein ID: WP_000469482.1
Location: 50216..50731 (516 bp)
Type: Others
Protein ID: WP_001201509.1
Location: 52040..52165 (126 bp)
Type: Others
Protein ID: WP_001900195.1
Location: 52181..52219 (39 bp)
Type: Others
Protein ID: WP_106019118.1
Location: 52415..52861 (447 bp)
Type: Others
Protein ID: WP_000006157.1
Location: 52924..54135 (1212 bp)
Type: Others
Protein ID: WP_001122813.1
Location: 55148..55426 (279 bp)
Type: Others
Protein ID: WP_001921601.1
Location: 55678..55884 (207 bp)
Type: Others
Protein ID: Protein_69
Location: 56084..56185 (102 bp)
Type: Others
Protein ID: WP_001921603.1
Location: 56175..56561 (387 bp)
Type: Others
Protein ID: WP_000703163.1
Location: 56756..57007 (252 bp)
Type: Others
Protein ID: WP_001890111.1
Location: 56980..57129 (150 bp)
Type: Others
Protein ID: WP_071908333.1
Location: 57221..57463 (243 bp)
Type: Others
Protein ID: WP_000107461.1
Location: 57715..57993 (279 bp)
Type: Others
Protein ID: WP_000280324.1
Location: 58368..58511 (144 bp)
Type: Others
Protein ID: Protein_76
Location: 58565..58603 (39 bp)
Type: Others
Protein ID: WP_082798268.1
Location: 58815..59282 (468 bp)
Type: Others
Protein ID: WP_001289288.1
Location: 50881..51378 (498 bp)
Type: Others
Protein ID: WP_000982260.1
Location: 51375..51647 (273 bp)
Type: Others
Protein ID: WP_000246253.1
Location: 54322..54591 (270 bp)
Type: Toxin
Protein ID: WP_000277238.1
Location: 54584..54862 (279 bp)
Type: Antitoxin
Protein ID: WP_001258569.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
EN18_RS1439549543..50079+537WP_000469482.1GNAT family N-acetyltransferase-
EN18_RS1440050216..50731+516WP_001201509.1lipocalin family protein-
EN18_RS1440550881..51378-498WP_000982260.1GNAT family N-acetyltransferase-
EN18_RS1441051375..51647-273WP_000246253.1DUF1778 domain-containing protein-
EN18_RS2108552040..52165+126WP_001900195.1DUF645 family protein-
EN18_RS2109052181..52219+39WP_106019118.1hypothetical protein-
EN18_RS1442552415..52861+447WP_000006157.1hypothetical protein-
EN18_RS1443052924..54135+1212WP_001122813.1IS256 family transposase-
EN18_RS1443554322..54591-270WP_000277238.1type II toxin-antitoxin system YafQ family toxinToxin
EN18_RS1444054584..54862-279WP_001258569.1type II toxin-antitoxin system RelB/DinJ family antitoxinAntitoxin
EN18_RS2051055148..55426+279WP_001921601.1DUF3709 domain-containing protein-
EN18_RS2110555678..55884+207Protein_69DUF3709 domain-containing protein-
EN18_RS2111056084..56185+102WP_001921603.1hypothetical protein-
EN18_RS1445056175..56561+387WP_000703163.1VOC family protein-
EN18_RS1445556756..57007+252WP_001890111.1TIGR03643 family protein-
EN18_RS2052056980..57129+150WP_071908333.1DUF3265 domain-containing protein-
EN18_RS1446057221..57463+243WP_000107461.1hypothetical protein-
EN18_RS1446557715..57993+279WP_000280324.1DUF3709 domain-containing protein-
EN18_RS2154058368..58511+144Protein_76DUF645 family protein-
EN18_RS2154558565..58603+39WP_082798268.1hypothetical protein-
EN18_RS1447558815..59282+468WP_001289288.1OsmC family protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-31037..137542106505
insideIntegron--36117..137166101049
-flankIS/Tn--52924..541351211


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-85)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10406.11 Da        Isoelectric Point: 9.5084

>T46751 WP_000277238.1 NZ_CP007635:c54591-54322 [Vibrio cholerae]
MYKLEYSTQFKKDFKKITKMPISDIIEVGNVISKLQRGEKLEPKNVDHPLTGNWVGFRDCHIKPDLVLIYRVFNDQLQLA
RIGSHSDLF

Download         Length: 270 bp

>T46751 NZ_CP007635:c54591-54322 [Vibrio cholerae]
ATGTATAAACTCGAATACTCCACACAGTTTAAGAAAGATTTCAAAAAGATAACTAAGATGCCGATTTCAGACATCATTGA
AGTCGGCAATGTTATTTCTAAGCTGCAACGCGGCGAAAAGCTTGAACCCAAGAATGTTGACCATCCGTTAACTGGAAATT
GGGTTGGATTTCGAGACTGCCACATTAAACCCGACCTAGTGTTAATCTATCGAGTTTTTAACGATCAACTACAACTAGCG
CGCATTGGTTCACATAGTGATTTATTCTAA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10088.58 Da        Isoelectric Point: 6.0728

>AT46751 WP_001258569.1 NZ_CP007635:c54862-54584 [Vibrio cholerae]
MRTEMLSTRIDHDTKIAFTNVCDEMGLSTSQAIKLFAKAVINHGGIPFELRVPQPNEVTASAIQELVEGKGHKAESVEAM
LNELTEGKVKHV

Download         Length: 279 bp

>AT46751 NZ_CP007635:c54862-54584 [Vibrio cholerae]
ATGAGAACAGAAATGCTGAGCACGCGCATTGACCACGACACGAAAATTGCGTTCACAAACGTCTGCGATGAGATGGGTCT
AAGTACATCACAGGCCATAAAGTTATTTGCAAAAGCGGTTATTAATCATGGTGGAATCCCTTTTGAGCTGCGAGTTCCAC
AGCCTAATGAGGTTACTGCATCTGCAATTCAAGAGCTCGTTGAAGGAAAAGGACATAAAGCTGAATCCGTTGAAGCTATG
CTGAATGAGCTTACTGAAGGCAAAGTTAAGCATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A151JGK8

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A151KTP9

References