58383

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 206207..206735 Replicon chromosome
Accession NZ_CP013316
Organism Vibrio cholerae strain M2140

Toxin (Protein)


Gene name relE Uniprot ID A0A0X1KZS6
Locus tag ASZ83_RS15485 Protein ID WP_000221354.1
Coordinates 206448..206735 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0X1KZS8
Locus tag ASZ83_RS15480 Protein ID WP_001250179.1
Coordinates 206207..206458 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ASZ83_RS20485 201261..201299 + 39 WP_106019119.1 hypothetical protein -
ASZ83_RS15440 201512..202516 + 1005 WP_000964925.1 LD-carboxypeptidase -
ASZ83_RS15445 202669..203115 + 447 WP_000128977.1 hypothetical protein -
ASZ83_RS15450 203235..204164 + 930 WP_000335802.1 hypothetical protein -
ASZ83_RS20210 204161..204271 + 111 WP_071917832.1 DUF3265 domain-containing protein -
ASZ83_RS15460 204299..204991 + 693 WP_001047177.1 GNAT family N-acetyltransferase -
ASZ83_RS15465 204991..205392 + 402 WP_000351248.1 type II toxin-antitoxin system death-on-curing family toxin -
ASZ83_RS20215 205362..205505 + 144 WP_071908341.1 DUF3265 domain-containing protein -
ASZ83_RS15475 205580..205993 + 414 WP_000049417.1 VOC family protein -
ASZ83_RS15480 206207..206458 + 252 WP_001250179.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
ASZ83_RS15485 206448..206735 + 288 WP_000221354.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ASZ83_RS15490 206863..207318 + 456 WP_001245327.1 GNAT family N-acetyltransferase -
ASZ83_RS15500 207640..207792 + 153 WP_001884520.1 DUF645 family protein -
ASZ83_RS15505 207994..208491 - 498 WP_000982260.1 GNAT family N-acetyltransferase -
ASZ83_RS15510 208488..208760 - 273 WP_000246253.1 DUF1778 domain-containing protein -
ASZ83_RS15515 208991..209659 + 669 WP_000043871.1 hypothetical protein -
ASZ83_RS15520 209811..210098 + 288 WP_000426470.1 hypothetical protein -
ASZ83_RS15525 210239..210610 + 372 WP_001164080.1 nucleotide pyrophosphohydrolase -
ASZ83_RS15530 210677..211102 + 426 WP_001882332.1 DUF1778 domain-containing protein -
ASZ83_RS15535 211099..211632 + 534 WP_000118351.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 87981..224211 136230
inside Integron - - 93061..221594 128533


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(11-71)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10991.96 Da        Isoelectric Point: 10.4934

>T58383 WP_000221354.1 NZ_CP013316:206448-206735 [Vibrio cholerae]
MTYKLKFLPAAQKEWSKLAPTIQSQFKKKLKERLENPHVPSAKLRGYDAVYKIKLRTAGYRLAYEVIDDEIVVYVLAVGK
RDKDAVYKKLASRFG

Download         Length: 288 bp

>T58383 NZ_CP013316:206448-206735 [Vibrio cholerae]
ATGACCTATAAGTTAAAGTTTCTGCCGGCTGCGCAAAAGGAATGGAGTAAGTTAGCTCCGACAATTCAGAGTCAGTTCAA
GAAGAAGTTAAAGGAACGATTAGAAAATCCGCACGTCCCTTCGGCTAAGCTTCGAGGATACGACGCTGTTTACAAGATTA
AACTTCGTACGGCGGGTTATCGTTTAGCTTATGAGGTTATTGACGATGAGATAGTTGTCTATGTCCTTGCTGTCGGTAAA
CGTGACAAAGATGCTGTCTATAAAAAACTGGCTTCACGCTTCGGTTAG

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9136.29 Da        Isoelectric Point: 4.0197

>AT58383 WP_001250179.1 NZ_CP013316:206207-206458 [Vibrio cholerae]
MRQVLANCSASISELKKNPTALLNEADGSAIAILNHNKPAAYLVPAETYEYLIDMLDDYELSQIVDSRRADLAQAVEVNI
DDL

Download         Length: 252 bp

>AT58383 NZ_CP013316:206207-206458 [Vibrio cholerae]
ATGAGACAAGTTTTAGCGAATTGCTCTGCAAGTATTTCAGAGTTAAAGAAGAACCCAACAGCTTTGTTGAATGAGGCTGA
TGGGTCTGCAATTGCAATTTTAAACCACAACAAGCCAGCGGCTTACCTTGTGCCAGCGGAAACGTATGAGTATCTCATCG
ATATGCTCGATGATTATGAGCTTTCCCAAATTGTCGATAGTCGCCGAGCTGACTTAGCACAAGCTGTGGAAGTAAATATT
GATGACCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0X1KZS6

Antitoxin

Source ID Structure
AlphaFold DB A0A0X1KZS8

References