Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 326606..327146 Replicon chromosome
Accession NZ_CP090379
Organism Vibrio cholerae strain BY369

Toxin (Protein)


Gene name relE Uniprot ID A0A151JGK8
Locus tag LVJ30_RS15280 Protein ID WP_000277238.1
Coordinates 326606..326875 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9KML3
Locus tag LVJ30_RS15285 Protein ID WP_001258569.1
Coordinates 326868..327146 (-) Length 93 a.a.

Genomic Context

LVJ30_RS15230LVJ30_RS15235LVJ30_RS15240LVJ30_RS15245LVJ30_RS15250LVJ30_RS15255LVJ30_RS15270LVJ30_RS15275LVJ30_RS15290LVJ30_RS15295LVJ30_RS15300LVJ30_RS15305LVJ30_RS15310LVJ30_RS15315LVJ30_RS15320LVJ30_RS15325LVJ30_RS15330LVJ30_RS15335LVJ30_RS15340LVJ30_RS15345LVJ30_RS15350LVJ30_RS15225LVJ30_RS15260LVJ30_RS15265LVJ30_RS15280LVJ30_RS15285
Location: 322096..322482 (387 bp)
Type: Others
Protein ID: WP_001015867.1
Location: 322539..322652 (114 bp)
Type: Others
Protein ID: WP_001900214.1
Location: 322661..322882 (222 bp)
Type: Others
Protein ID: WP_032467793.1
Location: 323140..323676 (537 bp)
Type: Others
Protein ID: WP_000469482.1
Location: 323867..324328 (462 bp)
Type: Others
Protein ID: WP_001903091.1
Location: 324393..324461 (69 bp)
Type: Others
Protein ID: Protein_284
Location: 325637..325762 (126 bp)
Type: Others
Protein ID: WP_001900195.1
Location: 326012..326458 (447 bp)
Type: Others
Protein ID: WP_000006157.1
Location: 327197..327314 (118 bp)
Type: Others
Protein ID: Protein_291
Location: 327432..327710 (279 bp)
Type: Others
Protein ID: WP_001921601.1
Location: 328070..328168 (99 bp)
Type: Others
Protein ID: WP_223225486.1
Location: 328368..328469 (102 bp)
Type: Others
Protein ID: WP_001921603.1
Location: 328459..328845 (387 bp)
Type: Others
Protein ID: WP_000703163.1
Location: 329040..329291 (252 bp)
Type: Others
Protein ID: WP_001890111.1
Location: 329264..329413 (150 bp)
Type: Others
Protein ID: WP_071908333.1
Location: 329505..329747 (243 bp)
Type: Others
Protein ID: WP_000107461.1
Location: 329999..330277 (279 bp)
Type: Others
Protein ID: WP_000280324.1
Location: 330709..330752 (44 bp)
Type: Others
Protein ID: Protein_300
Location: 330734..330827 (94 bp)
Type: Others
Protein ID: Protein_301
Location: 330796..330927 (132 bp)
Type: Others
Protein ID: WP_001883067.1
Location: 331099..331566 (468 bp)
Type: Others
Protein ID: WP_001289288.1
Location: 321610..321852 (243 bp)
Type: Others
Protein ID: WP_000557292.1
Location: 324478..324975 (498 bp)
Type: Others
Protein ID: WP_000982260.1
Location: 324972..325244 (273 bp)
Type: Others
Protein ID: WP_000246253.1
Location: 326606..326875 (270 bp)
Type: Toxin
Protein ID: WP_000277238.1
Location: 326868..327146 (279 bp)
Type: Antitoxin
Protein ID: WP_001258569.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
LVJ30_RS15225 (LVJ30_15230)321610..321852-243WP_000557292.1type II toxin-antitoxin system Phd/YefM family antitoxin-
LVJ30_RS15230 (LVJ30_15235)322096..322482+387WP_001015867.1NUDIX hydrolase-
LVJ30_RS15235 (LVJ30_15240)322539..322652+114WP_001900214.1hypothetical protein-
LVJ30_RS15240 (LVJ30_15245)322661..322882+222WP_032467793.1DUF1289 domain-containing protein-
LVJ30_RS15245 (LVJ30_15250)323140..323676+537WP_000469482.1GNAT family protein-
LVJ30_RS15250 (LVJ30_15255)323867..324328+462WP_001903091.1lipocalin family protein-
LVJ30_RS15255 (LVJ30_15260)324393..324461+69Protein_284acetyltransferase-
LVJ30_RS15260 (LVJ30_15265)324478..324975-498WP_000982260.1GNAT family N-acetyltransferase-
LVJ30_RS15265 (LVJ30_15270)324972..325244-273WP_000246253.1DUF1778 domain-containing protein-
LVJ30_RS15270 (LVJ30_15275)325637..325762+126WP_001900195.1DUF645 family protein-
LVJ30_RS15275 (LVJ30_15280)326012..326458+447WP_000006157.1hypothetical protein-
LVJ30_RS15280 (LVJ30_15285)326606..326875-270WP_000277238.1type II toxin-antitoxin system YafQ family toxinToxin
LVJ30_RS15285 (LVJ30_15290)326868..327146-279WP_001258569.1type II toxin-antitoxin system RelB/DinJ family antitoxinAntitoxin
LVJ30_RS15290 (LVJ30_15295)327197..327314+118Protein_291DUF3265 domain-containing protein-
LVJ30_RS15295 (LVJ30_15300)327432..327710+279WP_001921601.1DUF3709 domain-containing protein-
LVJ30_RS15300 (LVJ30_15305)328070..328168+99WP_223225486.1DUF3709 domain-containing protein-
LVJ30_RS15305 (LVJ30_15310)328368..328469+102WP_001921603.1hypothetical protein-
LVJ30_RS15310 (LVJ30_15315)328459..328845+387WP_000703163.1VOC family protein-
LVJ30_RS15315 (LVJ30_15320)329040..329291+252WP_001890111.1TIGR03643 family protein-
LVJ30_RS15320 (LVJ30_15325)329264..329413+150WP_071908333.1DUF3265 domain-containing protein-
LVJ30_RS15325 (LVJ30_15330)329505..329747+243WP_000107461.1hypothetical protein-
LVJ30_RS15330 (LVJ30_15335)329999..330277+279WP_000280324.1DUF3709 domain-containing protein-
LVJ30_RS15335 (LVJ30_15340)330709..330752+44Protein_300hypothetical protein-
LVJ30_RS15340 (LVJ30_15345)330734..330827+94Protein_301ggdef family protein-
LVJ30_RS15345 (LVJ30_15350)330796..330927+132WP_001883067.1hypothetical protein-
LVJ30_RS15350 (LVJ30_15355)331099..331566+468WP_001289288.1OsmC family protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-304645..39989295247
insideIntegron--309725..39951689791


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-85)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10406.11 Da        Isoelectric Point: 9.5084

>T230517 WP_000277238.1 NZ_CP090379:c326875-326606 [Vibrio cholerae]
MYKLEYSTQFKKDFKKITKMPISDIIEVGNVISKLQRGEKLEPKNVDHPLTGNWVGFRDCHIKPDLVLIYRVFNDQLQLA
RIGSHSDLF

Download         Length: 270 bp

>T230517 NZ_CP124916:592373-592489 [Enterococcus faecalis]
ATGTTTTTGTCCGTTGAAGCAGCGCTAGGACTGATGATTGGTTTTGCAACACTTGTTGTGACCATTATCTTCGGTATCTT
AGCGCTTGTCTTAGACAACAAAAATAACCGTTCATAA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10088.58 Da        Isoelectric Point: 6.0728

>AT230517 WP_001258569.1 NZ_CP090379:c327146-326868 [Vibrio cholerae]
MRTEMLSTRIDHDTKIAFTNVCDEMGLSTSQAIKLFAKAVINHGGIPFELRVPQPNEVTASAIQELVEGKGHKAESVEAM
LNELTEGKVKHV

Download         Length: 279 bp

>AT230517 NZ_CP124916:c592605-592400 [Enterococcus faecalis]
AAAAGAGAGATATGCAGGAACATACCTCTCTAATAGCCACTACTAGTTATAAGAACTAGCGGCTTACTGAGTTATTGGTT
TTATTTCAAACGCTTAACCGTTCAGCTCCTCAAAGCTTATGAACGGTTATTTTTGTTGTCTAAGACAAGCGCTAAGATAC
CGAAGATAATGGTCACAACAAGTGTTGCAAAACCAATCATCAGTCC

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A151JGK8

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A151KTP9

References