Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 384129..384657 Replicon chromosome
Accession NZ_CP090379
Organism Vibrio cholerae strain BY369

Toxin (Protein)


Gene name relE Uniprot ID A0A0X1KZS6
Locus tag LVJ30_RS15880 Protein ID WP_000221354.1
Coordinates 384370..384657 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0X1KZS8
Locus tag LVJ30_RS15875 Protein ID WP_001250179.1
Coordinates 384129..384380 (+) Length 84 a.a.

Genomic Context

LVJ30_RS15825LVJ30_RS15830LVJ30_RS15835LVJ30_RS15845LVJ30_RS15850LVJ30_RS15855LVJ30_RS15860LVJ30_RS15865LVJ30_RS15870LVJ30_RS15875LVJ30_RS15880LVJ30_RS15885LVJ30_RS15890LVJ30_RS15895LVJ30_RS15900LVJ30_RS15915LVJ30_RS15920LVJ30_RS15925LVJ30_RS15930LVJ30_RS15935LVJ30_RS15940LVJ30_RS15840LVJ30_RS15905LVJ30_RS15910
Location: 379397..379711 (315 bp)
Type: Others
Protein ID: WP_000071008.1
Location: 379848..380282 (435 bp)
Type: Others
Protein ID: WP_000256036.1
Location: 380450..380605 (156 bp)
Type: Others
Protein ID: WP_000751734.1
Location: 381778..382084 (307 bp)
Type: Others
Protein ID: Protein_402
Location: 382221..382619 (399 bp)
Type: Others
Protein ID: Protein_403
Location: 382743..382913 (171 bp)
Type: Others
Protein ID: WP_001080654.1
Location: 382913..383314 (402 bp)
Type: Others
Protein ID: WP_000351248.1
Location: 383317..383427 (111 bp)
Type: Others
Protein ID: WP_082798255.1
Location: 383502..383915 (414 bp)
Type: Others
Protein ID: WP_000049417.1
Location: 384129..384380 (252 bp)
Type: Antitoxin
Protein ID: WP_001250179.1
Location: 384370..384657 (288 bp)
Type: Toxin
Protein ID: WP_000221354.1
Location: 384785..385240 (456 bp)
Type: Others
Protein ID: WP_001245327.1
Location: 385297..385419 (123 bp)
Type: Others
Protein ID: Protein_411
Location: 385590..385714 (125 bp)
Type: Others
Protein ID: Protein_412
Location: 385831..385899 (69 bp)
Type: Others
Protein ID: Protein_413
Location: 386834..386896 (63 bp)
Type: Others
Protein ID: Protein_416
Location: 386913..387581 (669 bp)
Type: Others
Protein ID: WP_000043871.1
Location: 387733..388020 (288 bp)
Type: Others
Protein ID: WP_000426470.1
Location: 388161..388532 (372 bp)
Type: Others
Protein ID: WP_001164080.1
Location: 388755..389024 (270 bp)
Type: Others
Protein ID: WP_000179600.1
Location: 389021..389554 (534 bp)
Type: Others
Protein ID: WP_000118351.1
Location: 380730..381710 (981 bp)
Type: Others
Protein ID: WP_000019370.1
Location: 385916..386413 (498 bp)
Type: Others
Protein ID: WP_000982260.1
Location: 386410..386682 (273 bp)
Type: Others
Protein ID: WP_000246253.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
LVJ30_RS15825 (LVJ30_15825)379397..379711+315WP_000071008.1DNA-binding transcriptional regulator-
LVJ30_RS15830 (LVJ30_15830)379848..380282+435WP_000256036.1GNAT family N-acetyltransferase-
LVJ30_RS15835 (LVJ30_15835)380450..380605+156WP_000751734.1hypothetical protein-
LVJ30_RS15840 (LVJ30_15840)380730..381710-981WP_000019370.1IS5-like element ISVch5 family transposase-
LVJ30_RS15845 (LVJ30_15845)381778..382084+307Protein_402CatB-related O-acetyltransferase-
LVJ30_RS15850 (LVJ30_15850)382221..382619+399Protein_403GNAT family N-acetyltransferase-
LVJ30_RS15855 (LVJ30_15855)382743..382913+171WP_001080654.1hypothetical protein-
LVJ30_RS15860 (LVJ30_15860)382913..383314+402WP_000351248.1type II toxin-antitoxin system death-on-curing family toxin-
LVJ30_RS15865 (LVJ30_15865)383317..383427+111WP_082798255.1DUF3265 domain-containing protein-
LVJ30_RS15870 (LVJ30_15870)383502..383915+414WP_000049417.1VOC family protein-
LVJ30_RS15875 (LVJ30_15875)384129..384380+252WP_001250179.1type II toxin-antitoxin system Phd/YefM family antitoxinAntitoxin
LVJ30_RS15880 (LVJ30_15880)384370..384657+288WP_000221354.1type II toxin-antitoxin system RelE/ParE family toxinToxin
LVJ30_RS15885 (LVJ30_15885)384785..385240+456WP_001245327.1GNAT family N-acetyltransferase-
LVJ30_RS15890 (LVJ30_15890)385297..385419+123Protein_411acetyltransferase-
LVJ30_RS15895 (LVJ30_15895)385590..385714+125Protein_412DUF645 family protein-
LVJ30_RS15900 (LVJ30_15900)385831..385899+69Protein_413acetyltransferase-
LVJ30_RS15905 (LVJ30_15905)385916..386413-498WP_000982260.1GNAT family N-acetyltransferase-
LVJ30_RS15910 (LVJ30_15910)386410..386682-273WP_000246253.1DUF1778 domain-containing protein-
LVJ30_RS15915 (LVJ30_15915)386834..386896+63Protein_416acetyltransferase-
LVJ30_RS15920 (LVJ30_15920)386913..387581+669WP_000043871.1hypothetical protein-
LVJ30_RS15925 (LVJ30_15925)387733..388020+288WP_000426470.1hypothetical protein-
LVJ30_RS15930 (LVJ30_15930)388161..388532+372WP_001164080.1MazG nucleotide pyrophosphohydrolase domain-containing protein-
LVJ30_RS15935 (LVJ30_15935)388755..389024+270WP_000179600.1DUF1778 domain-containing protein-
LVJ30_RS15940 (LVJ30_15940)389021..389554+534WP_000118351.1GNAT family N-acetyltransferase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-304645..39989295247
insideIntegron--309725..39951689791
flankIS/Tn--380730..381710980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(11-71)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10991.96 Da        Isoelectric Point: 10.4934

>T230525 WP_000221354.1 NZ_CP090379:384370-384657 [Vibrio cholerae]
MTYKLKFLPAAQKEWSKLAPTIQSQFKKKLKERLENPHVPSAKLRGYDAVYKIKLRTAGYRLAYEVIDDEIVVYVLAVGK
RDKDAVYKKLASRFG

Download         Length: 288 bp

>T230525 NZ_CP124918:571910-572026 [Enterococcus faecalis]
ATGTTTTTGTCCGTTGAAGCAGCGCTAGGACTGATGATTGGTTTTGCAACACTTGTTGTGACCATTATCTTCGGTATCTT
AGCGCTTGTCTTAGACAACAAAAATAACCGTTCATAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9136.29 Da        Isoelectric Point: 4.0197

>AT230525 WP_001250179.1 NZ_CP090379:384129-384380 [Vibrio cholerae]
MRQVLANCSASISELKKNPTALLNEADGSAIAILNHNKPAAYLVPAETYEYLIDMLDDYELSQIVDSRRADLAQAVEVNI
DDL

Download         Length: 252 bp

>AT230525 NZ_CP124918:c572142-571937 [Enterococcus faecalis]
AAAAGAGAGATATGCAGGAACATACCTCTCTAATAGCCACTACTAGTTATAAGAACTAGCGGCTTACTGAGTTATTGGTT
TTATTTCAAACGCTTAACCGTTCAGCTCCTCAAAGCTTATGAACGGTTATTTTTGTTGTCTAAGACAAGCGCTAAGATAC
CGAAGATAATGGTCACAACAAGTGTTGCAAAACCAATCATCAGTCC

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0X1KZS6

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A0X1KZS8

References