87017

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /GNAT-DUF1778
Location 324070..324836 Replicon chromosome
Accession NZ_CP024163
Organism Vibrio cholerae strain E7946

Toxin (Protein)


Gene name - Uniprot ID Q9K2P7
Locus tag CSW01_RS15635 Protein ID WP_000982260.1
Coordinates 324070..324567 (-) Length 166 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q9K2J6
Locus tag CSW01_RS15640 Protein ID WP_000246253.1
Coordinates 324564..324836 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CSW01_RS15570 319512..320216 + 705 WP_000087610.1 HNH endonuclease -
CSW01_RS15575 320374..320712 + 339 WP_000713853.1 hypothetical protein -
CSW01_RS15585 320866..321183 - 318 WP_001180243.1 type II toxin-antitoxin system RelE/ParE family toxin -
CSW01_RS15590 321202..321444 - 243 WP_000557292.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
CSW01_RS15595 321688..322074 + 387 WP_001015867.1 NUDIX hydrolase -
CSW01_RS15600 322131..322244 + 114 WP_001900214.1 hypothetical protein -
CSW01_RS15605 322193..322474 + 282 WP_001894429.1 DUF1289 domain-containing protein -
CSW01_RS15620 322732..323268 + 537 WP_000469482.1 GNAT family N-acetyltransferase -
CSW01_RS15625 323405..323920 + 516 WP_001201509.1 lipocalin family protein -
CSW01_RS15635 324070..324567 - 498 WP_000982260.1 GNAT family N-acetyltransferase Toxin
CSW01_RS15640 324564..324836 - 273 WP_000246253.1 DUF1778 domain-containing protein Antitoxin
CSW01_RS15650 325229..325354 + 126 WP_001900195.1 DUF645 family protein -
CSW01_RS19800 325370..325408 + 39 WP_106019118.1 hypothetical protein -
CSW01_RS15660 325604..326050 + 447 WP_000006157.1 hypothetical protein -
CSW01_RS15670 326198..326467 - 270 WP_000277238.1 type II toxin-antitoxin system YafQ family toxin -
CSW01_RS15675 326460..326738 - 279 WP_001258569.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
CSW01_RS15685 327024..327302 + 279 WP_001921601.1 DUF3709 domain-containing protein -
CSW01_RS19805 327554..327760 + 207 Protein_289 DUF3709 domain-containing protein -
CSW01_RS15690 327960..328061 + 102 WP_001921603.1 hypothetical protein -
CSW01_RS15695 328051..328437 + 387 WP_000703163.1 VOC family protein -
CSW01_RS15700 328632..328883 + 252 WP_001890111.1 TIGR03643 family protein -
CSW01_RS15705 328856..329005 + 150 WP_071908333.1 DUF3265 domain-containing protein -
CSW01_RS15710 329097..329339 + 243 WP_000107461.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 304226..433944 129718
inside Integron - - 309306..433568 124262


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(86-152)

Antitoxin

Vibrio phage ICP1, Orf50

(7-86)


Sequences

Toxin        


Download         Length: 166 a.a.        Molecular weight: 18527.18 Da        Isoelectric Point: 8.7753

>T87017 WP_000982260.1 NZ_CP024163:c324567-324070 [Vibrio cholerae]
MMNTVLLDKDKHDRNRFNCGTEALNNYLKVMASQQAKKDNTRTFVLEDDNNSAYIIGFYTLTMTPIDLKALPDKLQKKHQ
SSTSGGLIARLAVDDRYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKHFYERYGFQAFQDAENKLFITIADI
RASLG

Download         Length: 498 bp

>T87017 NZ_CP024163:c324567-324070 [Vibrio cholerae]
ATGATGAATACGGTACTTCTCGATAAAGATAAGCACGATAGGAACCGTTTCAATTGTGGCACTGAAGCACTCAACAATTA
CTTAAAAGTAATGGCGAGTCAGCAAGCCAAAAAAGACAACACCAGAACCTTCGTTTTGGAAGATGACAATAACAGTGCTT
ATATCATCGGCTTTTACACTCTGACTATGACGCCCATTGATTTGAAAGCCTTGCCCGACAAGTTACAAAAGAAGCACCAA
TCCTCAACCTCTGGAGGGCTCATTGCTCGTTTAGCTGTCGACGATAGATACAAAGGAAAAGGTTTTGGTGAGTGGCTACT
CATTGACGCTCTCAGAAAGCTACTCGCAGCCAGTGACAGTGTAGCGTTCCCTGTTGTCATTGTTGATGCCAAAGATGGTG
CAAAACATTTCTATGAGCGCTATGGGTTTCAAGCGTTTCAAGATGCCGAAAACAAACTCTTCATCACCATTGCTGATATC
AGAGCAAGCTTAGGCTAG

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9683.22 Da        Isoelectric Point: 6.2988

>AT87017 WP_000246253.1 NZ_CP024163:c324836-324564 [Vibrio cholerae]
MATTLPRITARVDVDTQDLLAKAAALAGMSSINSFVLNAAIEKAKQVIEREQALKLSQADAVLLMEALDNPAVVNAKLKL
ASERYESKTQ

Download         Length: 273 bp

>AT87017 NZ_CP024163:c324836-324564 [Vibrio cholerae]
ATGGCAACGACTTTGCCTCGCATCACCGCTAGAGTTGATGTCGATACTCAAGATTTACTCGCTAAGGCTGCTGCTCTTGC
TGGTATGTCTAGTATTAACTCATTTGTTTTGAATGCAGCAATCGAAAAAGCAAAACAAGTCATTGAACGTGAGCAAGCTC
TAAAGCTTAGCCAAGCTGATGCCGTATTGCTGATGGAAGCTCTTGATAATCCAGCTGTAGTAAATGCAAAGCTCAAATTG
GCATCCGAACGTTATGAGAGCAAAACTCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Q0KGB1

Antitoxin

Source ID Structure
AlphaFold DB A0A0F2IC79

References