Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /GNAT-DUF1778
Location 324070..324836 Replicon chromosome
Accession NZ_CP024163
Organism Vibrio cholerae strain E7946

Toxin (Protein)


Gene name - Uniprot ID Q9K2P7
Locus tag CSW01_RS15635 Protein ID WP_000982260.1
Coordinates 324070..324567 (-) Length 166 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q9K2J6
Locus tag CSW01_RS15640 Protein ID WP_000246253.1
Coordinates 324564..324836 (-) Length 91 a.a.

Genomic Context

CSW01_RS15570CSW01_RS15575CSW01_RS15595CSW01_RS15600CSW01_RS15605CSW01_RS15620CSW01_RS15625CSW01_RS15650CSW01_RS19800CSW01_RS15660CSW01_RS15685CSW01_RS19805CSW01_RS15690CSW01_RS15695CSW01_RS15700CSW01_RS15705CSW01_RS15710CSW01_RS15585CSW01_RS15590CSW01_RS15635CSW01_RS15640CSW01_RS15670CSW01_RS15675
Location: 319512..320216 (705 bp)
Type: Others
Protein ID: WP_000087610.1
Location: 320374..320712 (339 bp)
Type: Others
Protein ID: WP_000713853.1
Location: 321688..322074 (387 bp)
Type: Others
Protein ID: WP_001015867.1
Location: 322131..322244 (114 bp)
Type: Others
Protein ID: WP_001900214.1
Location: 322193..322474 (282 bp)
Type: Others
Protein ID: WP_001894429.1
Location: 322732..323268 (537 bp)
Type: Others
Protein ID: WP_000469482.1
Location: 323405..323920 (516 bp)
Type: Others
Protein ID: WP_001201509.1
Location: 325229..325354 (126 bp)
Type: Others
Protein ID: WP_001900195.1
Location: 325370..325408 (39 bp)
Type: Others
Protein ID: WP_106019118.1
Location: 325604..326050 (447 bp)
Type: Others
Protein ID: WP_000006157.1
Location: 327024..327302 (279 bp)
Type: Others
Protein ID: WP_001921601.1
Location: 327554..327760 (207 bp)
Type: Others
Protein ID: Protein_289
Location: 327960..328061 (102 bp)
Type: Others
Protein ID: WP_001921603.1
Location: 328051..328437 (387 bp)
Type: Others
Protein ID: WP_000703163.1
Location: 328632..328883 (252 bp)
Type: Others
Protein ID: WP_001890111.1
Location: 328856..329005 (150 bp)
Type: Others
Protein ID: WP_071908333.1
Location: 329097..329339 (243 bp)
Type: Others
Protein ID: WP_000107461.1
Location: 320866..321183 (318 bp)
Type: Others
Protein ID: WP_001180243.1
Location: 321202..321444 (243 bp)
Type: Others
Protein ID: WP_000557292.1
Location: 324070..324567 (498 bp)
Type: Toxin
Protein ID: WP_000982260.1
Location: 324564..324836 (273 bp)
Type: Antitoxin
Protein ID: WP_000246253.1
Location: 326198..326467 (270 bp)
Type: Others
Protein ID: WP_000277238.1
Location: 326460..326738 (279 bp)
Type: Others
Protein ID: WP_001258569.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
CSW01_RS15570319512..320216+705WP_000087610.1HNH endonuclease-
CSW01_RS15575320374..320712+339WP_000713853.1hypothetical protein-
CSW01_RS15585320866..321183-318WP_001180243.1type II toxin-antitoxin system RelE/ParE family toxin-
CSW01_RS15590321202..321444-243WP_000557292.1type II toxin-antitoxin system Phd/YefM family antitoxin-
CSW01_RS15595321688..322074+387WP_001015867.1NUDIX hydrolase-
CSW01_RS15600322131..322244+114WP_001900214.1hypothetical protein-
CSW01_RS15605322193..322474+282WP_001894429.1DUF1289 domain-containing protein-
CSW01_RS15620322732..323268+537WP_000469482.1GNAT family N-acetyltransferase-
CSW01_RS15625323405..323920+516WP_001201509.1lipocalin family protein-
CSW01_RS15635324070..324567-498WP_000982260.1GNAT family N-acetyltransferaseToxin
CSW01_RS15640324564..324836-273WP_000246253.1DUF1778 domain-containing proteinAntitoxin
CSW01_RS15650325229..325354+126WP_001900195.1DUF645 family protein-
CSW01_RS19800325370..325408+39WP_106019118.1hypothetical protein-
CSW01_RS15660325604..326050+447WP_000006157.1hypothetical protein-
CSW01_RS15670326198..326467-270WP_000277238.1type II toxin-antitoxin system YafQ family toxin-
CSW01_RS15675326460..326738-279WP_001258569.1type II toxin-antitoxin system RelB/DinJ family antitoxin-
CSW01_RS15685327024..327302+279WP_001921601.1DUF3709 domain-containing protein-
CSW01_RS19805327554..327760+207Protein_289DUF3709 domain-containing protein-
CSW01_RS15690327960..328061+102WP_001921603.1hypothetical protein-
CSW01_RS15695328051..328437+387WP_000703163.1VOC family protein-
CSW01_RS15700328632..328883+252WP_001890111.1TIGR03643 family protein-
CSW01_RS15705328856..329005+150WP_071908333.1DUF3265 domain-containing protein-
CSW01_RS15710329097..329339+243WP_000107461.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-304226..433944129718
insideIntegron--309306..433568124262


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(86-152)

Antitoxin

Vibrio phage ICP1, Orf50

(7-86)


Sequences

Toxin        


Download         Length: 166 a.a.        Molecular weight: 18527.18 Da        Isoelectric Point: 8.7753

>T87017 WP_000982260.1 NZ_CP024163:c324567-324070 [Vibrio cholerae]
MMNTVLLDKDKHDRNRFNCGTEALNNYLKVMASQQAKKDNTRTFVLEDDNNSAYIIGFYTLTMTPIDLKALPDKLQKKHQ
SSTSGGLIARLAVDDRYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKHFYERYGFQAFQDAENKLFITIADI
RASLG

Download         Length: 498 bp

>T87017 NZ_CP024163:c324567-324070 [Vibrio cholerae]
ATGATGAATACGGTACTTCTCGATAAAGATAAGCACGATAGGAACCGTTTCAATTGTGGCACTGAAGCACTCAACAATTA
CTTAAAAGTAATGGCGAGTCAGCAAGCCAAAAAAGACAACACCAGAACCTTCGTTTTGGAAGATGACAATAACAGTGCTT
ATATCATCGGCTTTTACACTCTGACTATGACGCCCATTGATTTGAAAGCCTTGCCCGACAAGTTACAAAAGAAGCACCAA
TCCTCAACCTCTGGAGGGCTCATTGCTCGTTTAGCTGTCGACGATAGATACAAAGGAAAAGGTTTTGGTGAGTGGCTACT
CATTGACGCTCTCAGAAAGCTACTCGCAGCCAGTGACAGTGTAGCGTTCCCTGTTGTCATTGTTGATGCCAAAGATGGTG
CAAAACATTTCTATGAGCGCTATGGGTTTCAAGCGTTTCAAGATGCCGAAAACAAACTCTTCATCACCATTGCTGATATC
AGAGCAAGCTTAGGCTAG

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9683.22 Da        Isoelectric Point: 6.2988

>AT87017 WP_000246253.1 NZ_CP024163:c324836-324564 [Vibrio cholerae]
MATTLPRITARVDVDTQDLLAKAAALAGMSSINSFVLNAAIEKAKQVIEREQALKLSQADAVLLMEALDNPAVVNAKLKL
ASERYESKTQ

Download         Length: 273 bp

>AT87017 NZ_CP024163:c324836-324564 [Vibrio cholerae]
ATGGCAACGACTTTGCCTCGCATCACCGCTAGAGTTGATGTCGATACTCAAGATTTACTCGCTAAGGCTGCTGCTCTTGC
TGGTATGTCTAGTATTAACTCATTTGTTTTGAATGCAGCAATCGAAAAAGCAAAACAAGTCATTGAACGTGAGCAAGCTC
TAAAGCTTAGCCAAGCTGATGCCGTATTGCTGATGGAAGCTCTTGATAATCCAGCTGTAGTAAATGCAAAGCTCAAATTG
GCATCCGAACGTTATGAGAGCAAAACTCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0Q0KGB1

Antitoxin

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Source
ID
Structure
PDB1Y9B
AlphaFold DBA0A0F2IC79

References