Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 94424..95039 Replicon chromosome
Accession NZ_CP026648
Organism Vibrio cholerae O1 biovar El Tor strain HC1037

Toxin (Protein)


Gene name higB Uniprot ID Q9KMG5
Locus tag C4E16_RS14895 Protein ID WP_001162670.1
Coordinates 94424..94711 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag C4E16_RS14900 Protein ID WP_001232701.1
Coordinates 94722..95039 (+) Length 106 a.a.

Genomic Context

C4E16_RS19565C4E16_RS14865C4E16_RS14870C4E16_RS14875C4E16_RS14880C4E16_RS14885C4E16_RS14895C4E16_RS14900C4E16_RS19570C4E16_RS14915C4E16_RS19440C4E16_RS14925C4E16_RS14930C4E16_RS14935C4E16_RS14940C4E16_RS14945C4E16_RS14950C4E16_RS14855C4E16_RS14860
Location: 90060..90155 (96 bp)
Type: Others
Protein ID: WP_001907607.1
Location: 91169..91678 (510 bp)
Type: Others
Protein ID: WP_000405987.1
Location: 91735..92388 (654 bp)
Type: Others
Protein ID: WP_000226874.1
Location: 92698..92916 (219 bp)
Type: Others
Protein ID: WP_001917086.1
Location: 93319..93552 (234 bp)
Type: Others
Protein ID: WP_032482776.1
Location: 93977..94157 (181 bp)
Type: Others
Protein ID: Protein_139
Location: 94424..94711 (288 bp)
Type: Toxin
Protein ID: WP_001162670.1
Location: 94722..95039 (318 bp)
Type: Antitoxin
Protein ID: WP_001232701.1
Location: 95036..95146 (111 bp)
Type: Others
Protein ID: WP_134814058.1
Location: 95323..95448 (126 bp)
Type: Others
Protein ID: WP_001944767.1
Location: 95464..95502 (39 bp)
Type: Others
Protein ID: WP_106019119.1
Location: 95715..96719 (1005 bp)
Type: Others
Protein ID: WP_000964925.1
Location: 96872..97318 (447 bp)
Type: Others
Protein ID: WP_000128977.1
Location: 97438..98367 (930 bp)
Type: Others
Protein ID: WP_000335802.1
Location: 98364..98474 (111 bp)
Type: Others
Protein ID: WP_071917832.1
Location: 98502..98978 (477 bp)
Type: Others
Protein ID: WP_001047180.1
Location: 99115..99630 (516 bp)
Type: Others
Protein ID: WP_001201528.1
Location: 90349..90666 (318 bp)
Type: Others
Protein ID: WP_001180243.1
Location: 90685..90927 (243 bp)
Type: Others
Protein ID: WP_000557292.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
C4E16_RS1956590060..90155+96WP_001907607.1DUF645 family protein-
C4E16_RS1485590349..90666-318WP_001180243.1type II toxin-antitoxin system RelE/ParE family toxin-
C4E16_RS1486090685..90927-243WP_000557292.1type II toxin-antitoxin system Phd/YefM family antitoxin-
C4E16_RS1486591169..91678+510WP_000405987.1GNAT family N-acetyltransferase-
C4E16_RS1487091735..92388+654WP_000226874.1hypothetical protein-
C4E16_RS1487592698..92916+219WP_001917086.1DUF3709 domain-containing protein-
C4E16_RS1488093319..93552+234WP_032482776.1DUF3709 domain-containing protein-
C4E16_RS1488593977..94157+181Protein_139DUF645 family protein-
C4E16_RS1489594424..94711+288WP_001162670.1type II toxin-antitoxin system RelE/ParE family toxinToxin
C4E16_RS1490094722..95039+318WP_001232701.1HigA family addiction module antidote proteinAntitoxin
C4E16_RS1957095036..95146+111WP_134814058.1DUF3265 domain-containing protein-
C4E16_RS1491595323..95448+126WP_001944767.1DUF645 family protein-
C4E16_RS1944095464..95502+39WP_106019119.1hypothetical protein-
C4E16_RS1492595715..96719+1005WP_000964925.1LD-carboxypeptidase-
C4E16_RS1493096872..97318+447WP_000128977.1hypothetical protein-
C4E16_RS1493597438..98367+930WP_000335802.1hypothetical protein-
C4E16_RS1494098364..98474+111WP_071917832.1DUF3265 domain-containing protein-
C4E16_RS1494598502..98978+477WP_001047180.1GNAT family N-acetyltransferase-
C4E16_RS1495099115..99630+516WP_001201528.1lipocalin family protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-31043..136234105191
insideIntegron--36123..13585899735


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(2-95)

Antitoxin

Cro/C1-type helix-turn-helix domain

(12-69)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11349.95 Da        Isoelectric Point: 6.7187

>T95382 WP_001162670.1 NZ_CP026648:94424-94711 [Vibrio cholerae O1 biovar El Tor]
MALEFKDKWLEQFYEDDKRHRLIPSSIENALFRKLEILDAAQAESDLRIPPGNRFEHLEGNLKGWCSIRVNKQYRLIFQW
VDGVALNTYLDPHKY

Download         Length: 288 bp

>T95382 NZ_CP026648:94424-94711 [Vibrio cholerae O1 biovar El Tor]
ATGGCATTAGAATTTAAAGATAAGTGGTTAGAGCAGTTTTACGAGGATGATAAACGACATCGTTTAATTCCAAGTAGCAT
AGAGAATGCTCTATTTCGGAAGCTGGAAATCTTAGATGCAGCTCAAGCTGAATCAGACTTAAGAATTCCACCGGGTAATC
GTTTTGAACATCTTGAAGGAAATCTTAAAGGTTGGTGTTCAATTCGAGTGAACAAACAGTATCGTTTGATTTTTCAGTGG
GTTGATGGTGTTGCACTAAATACTTACTTAGACCCACATAAGTATTGA

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11705.63 Da        Isoelectric Point: 10.4711

>AT95382 WP_001232701.1 NZ_CP026648:94722-95039 [Vibrio cholerae O1 biovar El Tor]
MRKTKRRPVSVGEMLKVEFLEPMGITSKALAEAMGVHRNTVSNLINGGVLTAPVAIKLAAALGNTPEFWLNIQHAVDLWD
TRNRYQEEAKFVKPLFVSLEQSART

Download         Length: 318 bp

>AT95382 NZ_CP026648:94722-95039 [Vibrio cholerae O1 biovar El Tor]
ATGCGTAAGACAAAACGTCGTCCAGTTAGCGTTGGGGAAATGTTAAAAGTTGAATTTCTTGAACCAATGGGCATCACATC
AAAAGCGCTCGCTGAAGCGATGGGCGTACACAGAAATACGGTCAGTAATTTAATTAATGGTGGTGTGTTAACAGCTCCGG
TAGCAATCAAGTTAGCCGCGGCATTAGGTAACACACCAGAATTTTGGCTTAACATTCAACATGCAGTTGATCTTTGGGAT
ACGAGAAATCGTTATCAAGAAGAAGCAAAGTTTGTAAAGCCGTTGTTTGTTTCGCTGGAACAAAGCGCACGTACATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0F2HI36

Antitoxin

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Source
ID
Structure
No matching records found

References