Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /BrnT(toxin)
Location 333949..334447 Replicon chromosome
Accession NZ_LT906615
Organism Vibrio cholerae O1 biovar El Tor str. N16961

Toxin (Protein)


Gene name - Uniprot ID Q9KMK7
Locus tag FY484_RS15495 Protein ID WP_000589156.1
Coordinates 333949..334215 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q9KMK6
Locus tag FY484_RS15500 Protein ID WP_000643598.1
Coordinates 334202..334447 (+) Length 82 a.a.

Genomic Context

FY484_RS15435FY484_RS15440FY484_RS15445FY484_RS15450FY484_RS15455FY484_RS15460FY484_RS15465FY484_RS19505FY484_RS19510FY484_RS15480FY484_RS15485FY484_RS15495FY484_RS15500FY484_RS15505FY484_RS15515FY484_RS15520FY484_RS15525FY484_RS15530FY484_RS15535FY484_RS15540FY484_RS15545
Location: 329370..329576 (207 bp)
Type: Others
Protein ID: Protein_292
Location: 329776..329877 (102 bp)
Type: Others
Protein ID: WP_001921603.1
Location: 329867..330253 (387 bp)
Type: Others
Protein ID: WP_000703163.1
Location: 330448..330699 (252 bp)
Type: Others
Protein ID: WP_001890111.1
Location: 330672..330821 (150 bp)
Type: Others
Protein ID: WP_071908333.1
Location: 330913..331155 (243 bp)
Type: Others
Protein ID: WP_000107461.1
Location: 331407..331685 (279 bp)
Type: Others
Protein ID: WP_000280324.1
Location: 332060..332203 (144 bp)
Type: Others
Protein ID: Protein_299
Location: 332257..332295 (39 bp)
Type: Others
Protein ID: WP_082798268.1
Location: 332507..332974 (468 bp)
Type: Others
Protein ID: WP_001289288.1
Location: 333102..333764 (663 bp)
Type: Others
Protein ID: WP_000960654.1
Location: 333949..334215 (267 bp)
Type: Toxin
Protein ID: WP_000589156.1
Location: 334202..334447 (246 bp)
Type: Antitoxin
Protein ID: WP_000643598.1
Location: 334543..335337 (795 bp)
Type: Others
Protein ID: WP_001911581.1
Location: 335440..335568 (129 bp)
Type: Others
Protein ID: WP_071908338.1
Location: 335629..335811 (183 bp)
Type: Others
Protein ID: WP_000923182.1
Location: 336027..337031 (1005 bp)
Type: Others
Protein ID: WP_000964920.1
Location: 337184..337543 (360 bp)
Type: Others
Protein ID: WP_001071541.1
Location: 337816..338049 (234 bp)
Type: Others
Protein ID: WP_001890112.1
Location: 338317..338823 (507 bp)
Type: Others
Protein ID: WP_000393074.1
Location: 338980..339366 (387 bp)
Type: Others
Protein ID: WP_000703163.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
FY484_RS15435329370..329576+207Protein_292DUF3709 domain-containing protein-
FY484_RS15440329776..329877+102WP_001921603.1hypothetical protein-
FY484_RS15445329867..330253+387WP_000703163.1VOC family protein-
FY484_RS15450330448..330699+252WP_001890111.1TIGR03643 family protein-
FY484_RS15455330672..330821+150WP_071908333.1DUF3265 domain-containing protein-
FY484_RS15460330913..331155+243WP_000107461.1hypothetical protein-
FY484_RS15465331407..331685+279WP_000280324.1DUF3709 domain-containing protein-
FY484_RS19505332060..332203+144Protein_299DUF645 family protein-
FY484_RS19510332257..332295+39WP_082798268.1hypothetical protein-
FY484_RS15480332507..332974+468WP_001289288.1OsmC family protein-
FY484_RS15485333102..333764+663WP_000960654.1hypothetical protein-
FY484_RS15495333949..334215+267WP_000589156.1BrnT family toxinToxin
FY484_RS15500334202..334447+246WP_000643598.1hypothetical proteinAntitoxin
FY484_RS15505334543..335337+795WP_001911581.1hypothetical protein-
FY484_RS15515335440..335568+129WP_071908338.1general secretion pathway protein GspI-
FY484_RS15520335629..335811+183WP_000923182.1DUF645 family protein-
FY484_RS15525336027..337031+1005WP_000964920.1LD-carboxypeptidase-
FY484_RS15530337184..337543+360WP_001071541.1VOC family protein-
FY484_RS15535337816..338049+234WP_001890112.1DUF3709 domain-containing protein-
FY484_RS15540338317..338823+507WP_000393074.1hypothetical protein-
FY484_RS15545338980..339366+387WP_000703163.1VOC family protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-304666..435761131095
insideIntegroncatB9-309746..435385125639


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(6-81)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10092.34 Da        Isoelectric Point: 7.3171

>T293795 WP_000589156.1 NZ_LT906615:333949-334215 [Vibrio cholerae O1 biovar El Tor str. N16961]
MIKFEFDENKSRSNLEKHGIDFHTAQGLWNDSDLIEIPANTSDEPRYLVVGLLNGKHWSGVITYRGTNIRIISVRRSRKA
EVSLYESA

Download         Length: 267 bp

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9478.77 Da        Isoelectric Point: 6.4832

>AT293795 WP_000643598.1 NZ_LT906615:334202-334447 [Vibrio cholerae O1 biovar El Tor str. N16961]
MKAHEFDAKFESDDDDIVMDLDLSQAKRPMHKQKRVNVDFPAWMLESLDREASRIGVTRQSIIKIWLAERLESVSHHSSV
R

Download         Length: 246 bp


Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A271VMP7

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A271VME2

References