Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 143997..144556 Replicon chromosome
Accession NZ_CP013316
Organism Vibrio cholerae strain M2140

Toxin (Protein)


Gene name relE Uniprot ID Q9K2M8
Locus tag ASZ83_RS14860 Protein ID WP_000578476.1
Coordinates 143997..144275 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9L991
Locus tag ASZ83_RS14865 Protein ID WP_000381183.1
Coordinates 144272..144556 (-) Length 95 a.a.

Genomic Context

ASZ83_RS14815ASZ83_RS14820ASZ83_RS14825ASZ83_RS14830ASZ83_RS14835ASZ83_RS14840ASZ83_RS14845ASZ83_RS14850ASZ83_RS14855ASZ83_RS14875ASZ83_RS14880ASZ83_RS14895ASZ83_RS14900ASZ83_RS14905ASZ83_RS14910ASZ83_RS14915ASZ83_RS14920ASZ83_RS14860ASZ83_RS14865
Location: 139075..139581 (507 bp)
Type: Others
Protein ID: WP_000393074.1
Location: 139738..140124 (387 bp)
Type: Others
Protein ID: WP_000703163.1
Location: 140381..140584 (204 bp)
Type: Others
Protein ID: WP_001911580.1
Location: 140779..141030 (252 bp)
Type: Others
Protein ID: WP_001890111.1
Location: 141003..141152 (150 bp)
Type: Others
Protein ID: WP_071908333.1
Location: 141299..141724 (426 bp)
Type: Others
Protein ID: WP_000415750.1
Location: 141930..142553 (624 bp)
Type: Others
Protein ID: WP_000247070.1
Location: 142766..143245 (480 bp)
Type: Others
Protein ID: WP_000009888.1
Location: 143433..143846 (414 bp)
Type: Others
Protein ID: WP_000049420.1
Location: 144751..145266 (516 bp)
Type: Others
Protein ID: WP_001201520.1
Location: 145331..145927 (597 bp)
Type: Others
Protein ID: WP_000255434.1
Location: 146319..146501 (183 bp)
Type: Others
Protein ID: WP_000923182.1
Location: 146701..147174 (474 bp)
Type: Others
Protein ID: WP_001161076.1
Location: 147189..147281 (93 bp)
Type: Others
Protein ID: WP_014378730.1
Location: 147323..147949 (627 bp)
Type: Others
Protein ID: WP_000365424.1
Location: 148072..148770 (699 bp)
Type: Others
Protein ID: WP_001890502.1
Location: 148780..148890 (111 bp)
Type: Others
Protein ID: WP_079857360.1
Location: 143997..144275 (279 bp)
Type: Toxin
Protein ID: WP_000578476.1
Location: 144272..144556 (285 bp)
Type: Antitoxin
Protein ID: WP_000381183.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
ASZ83_RS14815139075..139581+507WP_000393074.1hypothetical protein-
ASZ83_RS14820139738..140124+387WP_000703163.1VOC family protein-
ASZ83_RS14825140381..140584+204WP_001911580.1hypothetical protein-
ASZ83_RS14830140779..141030+252WP_001890111.1TIGR03643 family protein-
ASZ83_RS14835141003..141152+150WP_071908333.1DUF3265 domain-containing protein-
ASZ83_RS14840141299..141724+426WP_000415750.1hypothetical protein-
ASZ83_RS14845141930..142553+624WP_000247070.1DUF1349 domain-containing protein-
ASZ83_RS14850142766..143245+480WP_000009888.1lecithin retinol acyltransferase family protein-
ASZ83_RS14855143433..143846+414WP_000049420.1VOC family protein-
ASZ83_RS14860143997..144275-279WP_000578476.1type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE familyToxin
ASZ83_RS14865144272..144556-285WP_000381183.1type II toxin-antitoxin system RelB/DinJ family antitoxinAntitoxin
ASZ83_RS14875144751..145266+516WP_001201520.1lipocalin family protein-
ASZ83_RS14880145331..145927+597WP_000255434.1hypothetical protein-
ASZ83_RS14895146319..146501+183WP_000923182.1DUF645 family protein-
ASZ83_RS14900146701..147174+474WP_001161076.1GrpB family protein-
ASZ83_RS14905147189..147281+93WP_014378730.1DUF3265 domain-containing protein-
ASZ83_RS14910147323..147949+627WP_000365424.1LysE family translocator-
ASZ83_RS14915148072..148770+699WP_001890502.1hypothetical protein-
ASZ83_RS14920148780..148890+111WP_079857360.1DUF3265 domain-containing protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic island--87981..224211136230
insideIntegron--93061..221594128533


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-70)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10819.59 Da        Isoelectric Point: 5.1651

>T58378 WP_000578476.1 NZ_CP013316:c144275-143997 [Vibrio cholerae]
MIFWEEASLNDREKIFEFLYDFNPAAAKKTDELIEAKVENLLEQPLIGVQRDGIRGRLLIIPEISMIVSYWVDGSKIRIM
RVLHQKQKFPND

Download         Length: 279 bp

>T58378 NZ_CP013316:c144275-143997 [Vibrio cholerae]
ATGATTTTCTGGGAAGAAGCATCTCTCAATGATCGTGAGAAAATTTTCGAATTTCTCTACGACTTTAACCCAGCAGCGGC
TAAAAAAACGGATGAGCTCATAGAAGCCAAAGTCGAAAATTTGCTTGAGCAACCACTAATCGGTGTTCAGCGTGATGGCA
TTAGAGGCAGATTGCTTATTATCCCTGAGATATCAATGATTGTTTCGTATTGGGTTGATGGTTCTAAAATTCGAATAATG
CGTGTACTACATCAGAAACAAAAATTTCCAAACGACTGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10901.25 Da        Isoelectric Point: 8.0775

>AT58378 WP_000381183.1 NZ_CP013316:c144556-144272 [Vibrio cholerae]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKALSHDAWLTEQVNQAFEKFDSGKAVFIEHDIAKAR
MAERKAKIRNRGHA

Download         Length: 285 bp

>AT58378 NZ_CP013316:c144556-144272 [Vibrio cholerae]
ATGGATACTAGAATTCAATTTCGTGTAGACGAAGAAACAAAACGTTTAGCTCAACAAATGGCTGAAAGCCAAGGTCGAAC
TCTTAGCGATGCTTGCCGTGAACTCACTGAACAATTAGCTGAGCAGCAACGCAAGGCATTATCTCACGATGCATGGCTAA
CTGAACAAGTGAATCAAGCATTTGAGAAGTTCGACTCAGGAAAAGCAGTATTCATTGAACATGACATCGCCAAAGCACGA
ATGGCTGAACGTAAAGCTAAAATCCGAAATCGAGGCCACGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBQ9K2M8

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A067BL33

References