58378

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 143997..144556 Replicon chromosome
Accession NZ_CP013316
Organism Vibrio cholerae strain M2140

Toxin (Protein)


Gene name relE Uniprot ID Q9K2M8
Locus tag ASZ83_RS14860 Protein ID WP_000578476.1
Coordinates 143997..144275 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9L991
Locus tag ASZ83_RS14865 Protein ID WP_000381183.1
Coordinates 144272..144556 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ASZ83_RS14815 139075..139581 + 507 WP_000393074.1 hypothetical protein -
ASZ83_RS14820 139738..140124 + 387 WP_000703163.1 VOC family protein -
ASZ83_RS14825 140381..140584 + 204 WP_001911580.1 hypothetical protein -
ASZ83_RS14830 140779..141030 + 252 WP_001890111.1 TIGR03643 family protein -
ASZ83_RS14835 141003..141152 + 150 WP_071908333.1 DUF3265 domain-containing protein -
ASZ83_RS14840 141299..141724 + 426 WP_000415750.1 hypothetical protein -
ASZ83_RS14845 141930..142553 + 624 WP_000247070.1 DUF1349 domain-containing protein -
ASZ83_RS14850 142766..143245 + 480 WP_000009888.1 lecithin retinol acyltransferase family protein -
ASZ83_RS14855 143433..143846 + 414 WP_000049420.1 VOC family protein -
ASZ83_RS14860 143997..144275 - 279 WP_000578476.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
ASZ83_RS14865 144272..144556 - 285 WP_000381183.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
ASZ83_RS14875 144751..145266 + 516 WP_001201520.1 lipocalin family protein -
ASZ83_RS14880 145331..145927 + 597 WP_000255434.1 hypothetical protein -
ASZ83_RS14895 146319..146501 + 183 WP_000923182.1 DUF645 family protein -
ASZ83_RS14900 146701..147174 + 474 WP_001161076.1 GrpB family protein -
ASZ83_RS14905 147189..147281 + 93 WP_014378730.1 DUF3265 domain-containing protein -
ASZ83_RS14910 147323..147949 + 627 WP_000365424.1 LysE family translocator -
ASZ83_RS14915 148072..148770 + 699 WP_001890502.1 hypothetical protein -
ASZ83_RS14920 148780..148890 + 111 WP_079857360.1 DUF3265 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 87981..224211 136230
inside Integron - - 93061..221594 128533


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-70)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10819.59 Da        Isoelectric Point: 5.1651

>T58378 WP_000578476.1 NZ_CP013316:c144275-143997 [Vibrio cholerae]
MIFWEEASLNDREKIFEFLYDFNPAAAKKTDELIEAKVENLLEQPLIGVQRDGIRGRLLIIPEISMIVSYWVDGSKIRIM
RVLHQKQKFPND

Download         Length: 279 bp

>T58378 NZ_CP013316:c144275-143997 [Vibrio cholerae]
ATGATTTTCTGGGAAGAAGCATCTCTCAATGATCGTGAGAAAATTTTCGAATTTCTCTACGACTTTAACCCAGCAGCGGC
TAAAAAAACGGATGAGCTCATAGAAGCCAAAGTCGAAAATTTGCTTGAGCAACCACTAATCGGTGTTCAGCGTGATGGCA
TTAGAGGCAGATTGCTTATTATCCCTGAGATATCAATGATTGTTTCGTATTGGGTTGATGGTTCTAAAATTCGAATAATG
CGTGTACTACATCAGAAACAAAAATTTCCAAACGACTGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10901.25 Da        Isoelectric Point: 8.0775

>AT58378 WP_000381183.1 NZ_CP013316:c144556-144272 [Vibrio cholerae]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKALSHDAWLTEQVNQAFEKFDSGKAVFIEHDIAKAR
MAERKAKIRNRGHA

Download         Length: 285 bp

>AT58378 NZ_CP013316:c144556-144272 [Vibrio cholerae]
ATGGATACTAGAATTCAATTTCGTGTAGACGAAGAAACAAAACGTTTAGCTCAACAAATGGCTGAAAGCCAAGGTCGAAC
TCTTAGCGATGCTTGCCGTGAACTCACTGAACAATTAGCTGAGCAGCAACGCAAGGCATTATCTCACGATGCATGGCTAA
CTGAACAAGTGAATCAAGCATTTGAGAAGTTCGACTCAGGAAAAGCAGTATTCATTGAACATGACATCGCCAAAGCACGA
ATGGCTGAACGTAAAGCTAAAATCCGAAATCGAGGCCACGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q9K2M8

Antitoxin

Source ID Structure
AlphaFold DB A0A067BL33

References