38679

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 273814..274352 Replicon chromosome
Accession NZ_AP024554
Organism Vibrio cholerae strain IDH-03329

Toxin (Protein)


Gene name parE Uniprot ID Q9KMJ0
Locus tag K6J80_RS15305 Protein ID WP_000802136.1
Coordinates 274053..274352 (+) Length 100 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P58093
Locus tag K6J80_RS15300 Protein ID WP_001107719.1
Coordinates 273814..274056 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6J80_RS15265 269230..269370 - 141 WP_001883049.1 DUF3265 domain-containing protein -
K6J80_RS15270 269336..270271 - 936 WP_000051985.1 restriction endonuclease -
K6J80_RS15275 270552..271151 - 600 WP_000429495.1 DUF6338 family protein -
K6J80_RS15280 271306..271572 - 267 WP_000937852.1 hypothetical protein -
K6J80_RS15285 271786..272469 - 684 WP_000877436.1 hypothetical protein -
K6J80_RS15290 272893..272985 - 93 WP_014164112.1 DUF3265 domain-containing protein -
K6J80_RS15295 273007..273585 - 579 WP_000110120.1 hypothetical protein -
K6J80_RS15300 273814..274056 + 243 WP_001107719.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
K6J80_RS15305 274053..274352 + 300 WP_000802136.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K6J80_RS15310 274480..274875 - 396 WP_000870857.1 DUF3465 domain-containing protein -
K6J80_RS15315 275089..275268 - 180 WP_001883058.1 DUF645 family protein -
K6J80_RS15320 275846..275935 - 90 WP_072606010.1 DUF3265 domain-containing protein -
K6J80_RS15325 275966..276664 - 699 WP_001890502.1 hypothetical protein -
K6J80_RS15330 276787..277413 - 627 WP_000365424.1 LysE family translocator -
K6J80_RS15335 277455..277547 - 93 WP_014378730.1 DUF3265 domain-containing protein -
K6J80_RS15340 277562..278035 - 474 WP_001161076.1 GrpB family protein -
K6J80_RS15345 278235..278417 - 183 WP_000923182.1 DUF645 family protein -
K6J80_RS19050 278478..278615 - 138 WP_001890145.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 213119..319686 106567
inside Integron - - 213119..312856 99737


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-92)

Antitoxin

Antitoxin ParD

(1-79)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11589.29 Da        Isoelectric Point: 9.9232

>T38679 WP_000802136.1 NZ_AP024554:274053-274352 [Vibrio cholerae]
MKPFNLTVAAKADLRDIALFTQRRWGKEQRNVYLKQFDDSFWLLAENPDIGKSCDEIREGYRKFPQGSHVIFYQQTGSQQ
IRVIRILHKSMDVNPIFGA

Download         Length: 300 bp

>T38679 NZ_AP024554:274053-274352 [Vibrio cholerae]
ATGAAACCATTTAATCTTACCGTCGCCGCCAAAGCCGATTTACGTGATATTGCTTTATTCACTCAACGACGCTGGGGAAA
AGAGCAGCGAAATGTTTATTTAAAGCAATTCGATGATTCCTTTTGGCTTTTAGCGGAAAATCCCGACATTGGTAAATCAT
GCGATGAAATCCGAGAGGGATACAGAAAATTTCCCCAAGGGAGTCACGTCATCTTTTATCAGCAAACCGGCAGCCAACAA
ATCAGGGTGATCCGAATTCTTCATAAGAGCATGGATGTGAACCCAATATTCGGCGCATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8964.84 Da        Isoelectric Point: 4.1677

>AT38679 WP_001107719.1 NZ_AP024554:273814-274056 [Vibrio cholerae]
MAKNTSITLGEHFDGFITSQIQSGRYGSASEVIRSALRLLENQETKLQSLRQLLIEGEQSGDADYDLDSFINELDSENIR

Download         Length: 243 bp

>AT38679 NZ_AP024554:273814-274056 [Vibrio cholerae]
ATGGCTAAAAATACAAGTATCACTCTTGGTGAACACTTCGATGGCTTTATTACAAGCCAAATACAAAGTGGGCGTTACGG
CTCAGCAAGTGAAGTCATTCGCTCTGCGCTACGTCTACTCGAAAACCAAGAAACCAAACTACAGTCACTCCGTCAACTAC
TTATTGAAGGAGAGCAAAGTGGTGACGCTGATTATGACCTTGATAGCTTCATCAATGAACTCGATAGTGAAAACATTCGA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7R5A

Antitoxin

Source ID Structure
AlphaFold DB A0A151JFU4

References