Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 273814..274352 Replicon chromosome
Accession NZ_AP024554
Organism Vibrio cholerae strain IDH-03329

Toxin (Protein)


Gene name parE Uniprot ID Q9KMJ0
Locus tag K6J80_RS15305 Protein ID WP_000802136.1
Coordinates 274053..274352 (+) Length 100 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P58093
Locus tag K6J80_RS15300 Protein ID WP_001107719.1
Coordinates 273814..274056 (+) Length 81 a.a.

Genomic Context

K6J80_RS15300K6J80_RS15305K6J80_RS15265K6J80_RS15270K6J80_RS15275K6J80_RS15280K6J80_RS15285K6J80_RS15290K6J80_RS15295K6J80_RS15310K6J80_RS15315K6J80_RS15320K6J80_RS15325K6J80_RS15330K6J80_RS15335K6J80_RS15340K6J80_RS15345K6J80_RS19050
Location: 273814..274056 (243 bp)
Type: Antitoxin
Protein ID: WP_001107719.1
Location: 274053..274352 (300 bp)
Type: Toxin
Protein ID: WP_000802136.1
Location: 269230..269370 (141 bp)
Type: Others
Protein ID: WP_001883049.1
Location: 269336..270271 (936 bp)
Type: Others
Protein ID: WP_000051985.1
Location: 270552..271151 (600 bp)
Type: Others
Protein ID: WP_000429495.1
Location: 271306..271572 (267 bp)
Type: Others
Protein ID: WP_000937852.1
Location: 271786..272469 (684 bp)
Type: Others
Protein ID: WP_000877436.1
Location: 272893..272985 (93 bp)
Type: Others
Protein ID: WP_014164112.1
Location: 273007..273585 (579 bp)
Type: Others
Protein ID: WP_000110120.1
Location: 274480..274875 (396 bp)
Type: Others
Protein ID: WP_000870857.1
Location: 275089..275268 (180 bp)
Type: Others
Protein ID: WP_001883058.1
Location: 275846..275935 (90 bp)
Type: Others
Protein ID: WP_072606010.1
Location: 275966..276664 (699 bp)
Type: Others
Protein ID: WP_001890502.1
Location: 276787..277413 (627 bp)
Type: Others
Protein ID: WP_000365424.1
Location: 277455..277547 (93 bp)
Type: Others
Protein ID: WP_014378730.1
Location: 277562..278035 (474 bp)
Type: Others
Protein ID: WP_001161076.1
Location: 278235..278417 (183 bp)
Type: Others
Protein ID: WP_000923182.1
Location: 278478..278615 (138 bp)
Type: Others
Protein ID: WP_001890145.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
K6J80_RS15265269230..269370-141WP_001883049.1DUF3265 domain-containing protein-
K6J80_RS15270269336..270271-936WP_000051985.1restriction endonuclease-
K6J80_RS15275270552..271151-600WP_000429495.1DUF6338 family protein-
K6J80_RS15280271306..271572-267WP_000937852.1hypothetical protein-
K6J80_RS15285271786..272469-684WP_000877436.1hypothetical protein-
K6J80_RS15290272893..272985-93WP_014164112.1DUF3265 domain-containing protein-
K6J80_RS15295273007..273585-579WP_000110120.1hypothetical protein-
K6J80_RS15300273814..274056+243WP_001107719.1type II toxin-antitoxin system ParD family antitoxinAntitoxin
K6J80_RS15305274053..274352+300WP_000802136.1type II toxin-antitoxin system RelE/ParE family toxinToxin
K6J80_RS15310274480..274875-396WP_000870857.1DUF3465 domain-containing protein-
K6J80_RS15315275089..275268-180WP_001883058.1DUF645 family protein-
K6J80_RS15320275846..275935-90WP_072606010.1DUF3265 domain-containing protein-
K6J80_RS15325275966..276664-699WP_001890502.1hypothetical protein-
K6J80_RS15330276787..277413-627WP_000365424.1LysE family translocator-
K6J80_RS15335277455..277547-93WP_014378730.1DUF3265 domain-containing protein-
K6J80_RS15340277562..278035-474WP_001161076.1GrpB family protein-
K6J80_RS15345278235..278417-183WP_000923182.1DUF645 family protein-
K6J80_RS19050278478..278615-138WP_001890145.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-213119..319686106567
insideIntegron--213119..31285699737


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-92)

Antitoxin

Antitoxin ParD

(1-79)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11589.29 Da        Isoelectric Point: 9.9232

>T38679 WP_000802136.1 NZ_AP024554:274053-274352 [Vibrio cholerae]
MKPFNLTVAAKADLRDIALFTQRRWGKEQRNVYLKQFDDSFWLLAENPDIGKSCDEIREGYRKFPQGSHVIFYQQTGSQQ
IRVIRILHKSMDVNPIFGA

Download         Length: 300 bp

>T38679 NZ_AP024554:274053-274352 [Vibrio cholerae]
ATGAAACCATTTAATCTTACCGTCGCCGCCAAAGCCGATTTACGTGATATTGCTTTATTCACTCAACGACGCTGGGGAAA
AGAGCAGCGAAATGTTTATTTAAAGCAATTCGATGATTCCTTTTGGCTTTTAGCGGAAAATCCCGACATTGGTAAATCAT
GCGATGAAATCCGAGAGGGATACAGAAAATTTCCCCAAGGGAGTCACGTCATCTTTTATCAGCAAACCGGCAGCCAACAA
ATCAGGGTGATCCGAATTCTTCATAAGAGCATGGATGTGAACCCAATATTCGGCGCATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8964.84 Da        Isoelectric Point: 4.1677

>AT38679 WP_001107719.1 NZ_AP024554:273814-274056 [Vibrio cholerae]
MAKNTSITLGEHFDGFITSQIQSGRYGSASEVIRSALRLLENQETKLQSLRQLLIEGEQSGDADYDLDSFINELDSENIR

Download         Length: 243 bp

>AT38679 NZ_AP024554:273814-274056 [Vibrio cholerae]
ATGGCTAAAAATACAAGTATCACTCTTGGTGAACACTTCGATGGCTTTATTACAAGCCAAATACAAAGTGGGCGTTACGG
CTCAGCAAGTGAAGTCATTCGCTCTGCGCTACGTCTACTCGAAAACCAAGAAACCAAACTACAGTCACTCCGTCAACTAC
TTATTGAAGGAGAGCAAAGTGGTGACGCTGATTATGACCTTGATAGCTTCATCAATGAACTCGATAGTGAAAACATTCGA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
PDB7R5A

Antitoxin

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Source
ID
Structure
PDB7R5A
PDB7B22
AlphaFold DBA0A151JFU4

References