Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) dhiT-phd/-
Location 132686..133090 Replicon chromosome
Accession NZ_CP007635
Organism Vibrio cholerae strain 2012EL-2176

Toxin (Protein)


Gene name dhiT Uniprot ID A0A086SLD6
Locus tag EN18_RS15050 Protein ID WP_001114075.1
Coordinates 132821..133090 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag EN18_RS21240 Protein ID WP_099607150.1
Coordinates 132686..132790 (+) Length 35 a.a.

Genomic Context

EN18_RS15015EN18_RS15020EN18_RS15025EN18_RS15030EN18_RS15035EN18_RS15040EN18_RS15045EN18_RS21240EN18_RS15050EN18_RS15055EN18_RS21245EN18_RS15060EN18_RS15075EN18_RS15080EN18_RS15065EN18_RS15070
Location: 128187..129104 (918 bp)
Type: Others
Protein ID: WP_000186333.1
Location: 129261..129650 (390 bp)
Type: Others
Protein ID: WP_001081302.1
Location: 129786..129995 (210 bp)
Type: Others
Protein ID: Protein_203
Location: 130114..130551 (438 bp)
Type: Others
Protein ID: WP_000503169.1
Location: 130615..130833 (219 bp)
Type: Others
Protein ID: WP_071908318.1
Location: 131008..131880 (873 bp)
Type: Others
Protein ID: WP_000254716.1
Location: 132030..132629 (600 bp)
Type: Others
Protein ID: WP_001891245.1
Location: 132686..132790 (105 bp)
Type: Antitoxin
Protein ID: WP_099607150.1
Location: 132821..133090 (270 bp)
Type: Toxin
Protein ID: WP_001114075.1
Location: 133084..133605 (522 bp)
Type: Others
Protein ID: WP_000921691.1
Location: 133904..134029 (126 bp)
Type: Others
Protein ID: WP_001905700.1
Location: 134280..134675 (396 bp)
Type: Others
Protein ID: WP_001000867.1
Location: 135567..136082 (516 bp)
Type: Others
Protein ID: WP_000343779.1
Location: 136266..136679 (414 bp)
Type: Others
Protein ID: WP_000049420.1
Location: 134814..135092 (279 bp)
Type: Others
Protein ID: WP_000578476.1
Location: 135089..135373 (285 bp)
Type: Others
Protein ID: WP_000381183.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
EN18_RS15015128187..129104+918WP_000186333.1alpha/beta hydrolase-
EN18_RS15020129261..129650+390WP_001081302.1hypothetical protein-
EN18_RS15025129786..129995+210Protein_203GNAT family N-acetyltransferase-
EN18_RS15030130114..130551+438WP_000503169.1IS200/IS605-like element IS1004 family transposase-
EN18_RS15035130615..130833+219WP_071908318.1GNAT family N-acetyltransferase-
EN18_RS15040131008..131880+873WP_000254716.1DUF3800 domain-containing protein-
EN18_RS15045132030..132629+600WP_001891245.1glutathione S-transferase N-terminal domain-containing protein-
EN18_RS21240132686..132790+105WP_099607150.1acetyltransferaseAntitoxin
EN18_RS15050132821..133090+270WP_001114075.1DUF4160 domain-containing proteinToxin
EN18_RS15055133084..133605+522WP_000921691.1DUF2442 domain-containing protein-
EN18_RS21245133904..134029+126WP_001905700.1DUF645 family protein-
EN18_RS15060134280..134675+396WP_001000867.1hypothetical protein-
EN18_RS15065134814..135092-279WP_000578476.1type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family-
EN18_RS15070135089..135373-285WP_000381183.1type II toxin-antitoxin system RelB/DinJ family antitoxin-
EN18_RS15075135567..136082+516WP_000343779.1GNAT family N-acetyltransferase-
EN18_RS15080136266..136679+414WP_000049420.1VOC family protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-31037..137542106505
insideIntegron--36117..137166101049
flankIS/Tn--130114..130551437


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF4160

(9-74)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10310.94 Da        Isoelectric Point: 6.6303

>T46764 WP_001114075.1 NZ_CP007635:132821-133090 [Vibrio cholerae]
MPEIDALLGLSFCLYFFDNKQHKLPHIHVKYGSYELIIAIETGECLEGYLPNKQRKRAENHILEHREQLMVMWNKAVNGE
NPGKLGDLC

Download         Length: 270 bp

>T46764 NZ_CP007635:132821-133090 [Vibrio cholerae]
ATGCCAGAGATTGATGCCCTATTAGGTCTTTCATTTTGCTTGTACTTCTTTGATAACAAGCAGCATAAATTACCTCATAT
TCACGTTAAGTACGGTAGTTACGAGCTAATTATTGCTATTGAAACAGGTGAGTGTTTAGAGGGTTACTTACCCAATAAGC
AACGAAAACGTGCTGAAAACCATATTCTTGAACATCGAGAGCAATTGATGGTGATGTGGAATAAAGCGGTGAATGGTGAA
AATCCAGGTAAGTTAGGTGATTTATGTTGA

Antitoxin


Download         Length: 35 a.a.        Molecular weight: 3991.79 Da        Isoelectric Point: 9.2853

>AT46764 WP_099607150.1 NZ_CP007635:132686-132790 [Vibrio cholerae]
VVSVVVFEFSSMRCQPLRRALYAYRNCLLKDTLL

Download         Length: 105 bp

>AT46764 NZ_CP007635:132686-132790 [Vibrio cholerae]
GTGGTTTCGGTTGTTGTGTTTGAGTTTAGTAGTATGCGCTGCCAGCCCCTTAGGCGGGCGTTATATGCTTATAGGAATTG
TCTCCTAAAGGATACGCTGCTATAG

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A086SLD6

Antitoxin

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Source
ID
Structure
No matching records found

References