46764

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) dhiT-phd/-
Location 132686..133090 Replicon chromosome
Accession NZ_CP007635
Organism Vibrio cholerae strain 2012EL-2176

Toxin (Protein)


Gene name dhiT Uniprot ID A0A086SLD6
Locus tag EN18_RS15050 Protein ID WP_001114075.1
Coordinates 132821..133090 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag EN18_RS21240 Protein ID WP_099607150.1
Coordinates 132686..132790 (+) Length 35 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EN18_RS15015 128187..129104 + 918 WP_000186333.1 alpha/beta hydrolase -
EN18_RS15020 129261..129650 + 390 WP_001081302.1 hypothetical protein -
EN18_RS15025 129786..129995 + 210 Protein_203 GNAT family N-acetyltransferase -
EN18_RS15030 130114..130551 + 438 WP_000503169.1 IS200/IS605-like element IS1004 family transposase -
EN18_RS15035 130615..130833 + 219 WP_071908318.1 GNAT family N-acetyltransferase -
EN18_RS15040 131008..131880 + 873 WP_000254716.1 DUF3800 domain-containing protein -
EN18_RS15045 132030..132629 + 600 WP_001891245.1 glutathione S-transferase N-terminal domain-containing protein -
EN18_RS21240 132686..132790 + 105 WP_099607150.1 acetyltransferase Antitoxin
EN18_RS15050 132821..133090 + 270 WP_001114075.1 DUF4160 domain-containing protein Toxin
EN18_RS15055 133084..133605 + 522 WP_000921691.1 DUF2442 domain-containing protein -
EN18_RS21245 133904..134029 + 126 WP_001905700.1 DUF645 family protein -
EN18_RS15060 134280..134675 + 396 WP_001000867.1 hypothetical protein -
EN18_RS15065 134814..135092 - 279 WP_000578476.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family -
EN18_RS15070 135089..135373 - 285 WP_000381183.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
EN18_RS15075 135567..136082 + 516 WP_000343779.1 GNAT family N-acetyltransferase -
EN18_RS15080 136266..136679 + 414 WP_000049420.1 VOC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 31037..137542 106505
inside Integron - - 36117..137166 101049
flank IS/Tn - - 130114..130551 437


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF4160

(9-74)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10310.94 Da        Isoelectric Point: 6.6303

>T46764 WP_001114075.1 NZ_CP007635:132821-133090 [Vibrio cholerae]
MPEIDALLGLSFCLYFFDNKQHKLPHIHVKYGSYELIIAIETGECLEGYLPNKQRKRAENHILEHREQLMVMWNKAVNGE
NPGKLGDLC

Download         Length: 270 bp

>T46764 NZ_CP007635:132821-133090 [Vibrio cholerae]
ATGCCAGAGATTGATGCCCTATTAGGTCTTTCATTTTGCTTGTACTTCTTTGATAACAAGCAGCATAAATTACCTCATAT
TCACGTTAAGTACGGTAGTTACGAGCTAATTATTGCTATTGAAACAGGTGAGTGTTTAGAGGGTTACTTACCCAATAAGC
AACGAAAACGTGCTGAAAACCATATTCTTGAACATCGAGAGCAATTGATGGTGATGTGGAATAAAGCGGTGAATGGTGAA
AATCCAGGTAAGTTAGGTGATTTATGTTGA

Antitoxin


Download         Length: 35 a.a.        Molecular weight: 3991.79 Da        Isoelectric Point: 9.2853

>AT46764 WP_099607150.1 NZ_CP007635:132686-132790 [Vibrio cholerae]
VVSVVVFEFSSMRCQPLRRALYAYRNCLLKDTLL

Download         Length: 105 bp

>AT46764 NZ_CP007635:132686-132790 [Vibrio cholerae]
GTGGTTTCGGTTGTTGTGTTTGAGTTTAGTAGTATGCGCTGCCAGCCCCTTAGGCGGGCGTTATATGCTTATAGGAATTG
TCTCCTAAAGGATACGCTGCTATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A086SLD6

Antitoxin

Source ID Structure

References