Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /GNAT-DUF1778
Location 454488..455254 Replicon chromosome
Accession NZ_CP013314
Organism Vibrio cholerae strain E9120

Toxin (Protein)


Gene name - Uniprot ID Q9K2P7
Locus tag ASZ79_RS16940 Protein ID WP_000982260.1
Coordinates 454488..454985 (-) Length 166 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q9K2J6
Locus tag ASZ79_RS16945 Protein ID WP_000246253.1
Coordinates 454982..455254 (-) Length 91 a.a.

Genomic Context

ASZ79_RS16890ASZ79_RS16895ASZ79_RS16900ASZ79_RS20750ASZ79_RS16910ASZ79_RS16915ASZ79_RS16920ASZ79_RS16925ASZ79_RS16935ASZ79_RS16950ASZ79_RS16955ASZ79_RS16960ASZ79_RS16965ASZ79_RS16970ASZ79_RS16975ASZ79_RS16980ASZ79_RS16985ASZ79_RS16940ASZ79_RS16945
Location: 450350..450656 (307 bp)
Type: Others
Protein ID: Protein_499
Location: 450793..451485 (693 bp)
Type: Others
Protein ID: WP_001047169.1
Location: 451485..451886 (402 bp)
Type: Others
Protein ID: WP_000351248.1
Location: 451856..451999 (144 bp)
Type: Others
Protein ID: WP_071908341.1
Location: 452074..452487 (414 bp)
Type: Others
Protein ID: WP_000049417.1
Location: 452701..452952 (252 bp)
Type: Others
Protein ID: WP_001250179.1
Location: 452942..453229 (288 bp)
Type: Others
Protein ID: WP_000221354.1
Location: 453357..453812 (456 bp)
Type: Others
Protein ID: WP_001245327.1
Location: 454134..454286 (153 bp)
Type: Others
Protein ID: WP_001884520.1
Location: 455485..456153 (669 bp)
Type: Others
Protein ID: WP_000043871.1
Location: 456305..456592 (288 bp)
Type: Others
Protein ID: WP_000426470.1
Location: 456733..457104 (372 bp)
Type: Others
Protein ID: WP_001164080.1
Location: 457171..457596 (426 bp)
Type: Others
Protein ID: WP_001882332.1
Location: 457593..458126 (534 bp)
Type: Others
Protein ID: WP_000118351.1
Location: 458328..458585 (258 bp)
Type: Others
Protein ID: WP_000861987.1
Location: 458573..458875 (303 bp)
Type: Others
Protein ID: WP_000229317.1
Location: 459109..460026 (918 bp)
Type: Others
Protein ID: WP_000186333.1
Location: 454488..454985 (498 bp)
Type: Toxin
Protein ID: WP_000982260.1
Location: 454982..455254 (273 bp)
Type: Antitoxin
Protein ID: WP_000246253.1
ToxinAntitoxinOther genes
Loading, please wait
Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
ASZ79_RS16890450350..450656+307Protein_499CatB-related O-acetyltransferase-
ASZ79_RS16895450793..451485+693WP_001047169.1GNAT family N-acetyltransferase-
ASZ79_RS16900451485..451886+402WP_000351248.1type II toxin-antitoxin system death-on-curing family toxin-
ASZ79_RS20750451856..451999+144WP_071908341.1DUF3265 domain-containing protein-
ASZ79_RS16910452074..452487+414WP_000049417.1VOC family protein-
ASZ79_RS16915452701..452952+252WP_001250179.1type II toxin-antitoxin system Phd/YefM family antitoxin-
ASZ79_RS16920452942..453229+288WP_000221354.1type II toxin-antitoxin system RelE/ParE family toxin-
ASZ79_RS16925453357..453812+456WP_001245327.1GNAT family N-acetyltransferase-
ASZ79_RS16935454134..454286+153WP_001884520.1DUF645 family protein-
ASZ79_RS16940454488..454985-498WP_000982260.1GNAT family N-acetyltransferaseToxin
ASZ79_RS16945454982..455254-273WP_000246253.1DUF1778 domain-containing proteinAntitoxin
ASZ79_RS16950455485..456153+669WP_000043871.1hypothetical protein-
ASZ79_RS16955456305..456592+288WP_000426470.1hypothetical protein-
ASZ79_RS16960456733..457104+372WP_001164080.1nucleotide pyrophosphohydrolase-
ASZ79_RS16965457171..457596+426WP_001882332.1DUF1778 domain-containing protein-
ASZ79_RS16970457593..458126+534WP_000118351.1GNAT family N-acetyltransferase-
ASZ79_RS16975458328..458585+258WP_000861987.1type II toxin-antitoxin system Phd/YefM family antitoxin-
ASZ79_RS16980458573..458875+303WP_000229317.1type II toxin-antitoxin system RelE/ParE family toxin-
ASZ79_RS16985459109..460026+918WP_000186333.1alpha/beta hydrolase-

Associated MGEs

Loading, please wait
MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-304700..468464163764
insideIntegron--309780..468088158308
flankIS/Tn--449302..450282980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(86-152)

Antitoxin

Vibrio phage ICP1, Orf50

(7-86)


Sequences

Toxin        


Download         Length: 166 a.a.        Molecular weight: 18527.18 Da        Isoelectric Point: 8.7753

>T58365 WP_000982260.1 NZ_CP013314:c454985-454488 [Vibrio cholerae]
MMNTVLLDKDKHDRNRFNCGTEALNNYLKVMASQQAKKDNTRTFVLEDDNNSAYIIGFYTLTMTPIDLKALPDKLQKKHQ
SSTSGGLIARLAVDDRYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKHFYERYGFQAFQDAENKLFITIADI
RASLG

Download         Length: 498 bp

>T58365 NZ_CP013314:c454985-454488 [Vibrio cholerae]
ATGATGAATACGGTACTTCTCGATAAAGATAAGCACGATAGGAACCGTTTCAATTGTGGCACTGAAGCACTCAACAATTA
CTTAAAAGTAATGGCGAGTCAGCAAGCCAAAAAAGACAACACCAGAACCTTCGTTTTGGAAGATGACAATAACAGTGCTT
ATATCATCGGCTTTTACACTCTGACTATGACGCCCATTGATTTGAAAGCCTTGCCCGACAAGTTACAAAAGAAGCACCAA
TCCTCAACCTCTGGAGGGCTCATTGCTCGTTTAGCTGTCGACGATAGATACAAAGGAAAAGGTTTTGGTGAGTGGCTACT
CATTGACGCTCTCAGAAAGCTACTCGCAGCCAGTGACAGTGTAGCGTTCCCTGTTGTCATTGTTGATGCCAAAGATGGTG
CAAAACATTTCTATGAGCGCTATGGGTTTCAAGCGTTTCAAGATGCCGAAAACAAACTCTTCATCACCATTGCTGATATC
AGAGCAAGCTTAGGCTAG

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9683.22 Da        Isoelectric Point: 6.2988

>AT58365 WP_000246253.1 NZ_CP013314:c455254-454982 [Vibrio cholerae]
MATTLPRITARVDVDTQDLLAKAAALAGMSSINSFVLNAAIEKAKQVIEREQALKLSQADAVLLMEALDNPAVVNAKLKL
ASERYESKTQ

Download         Length: 273 bp

>AT58365 NZ_CP013314:c455254-454982 [Vibrio cholerae]
ATGGCAACGACTTTGCCTCGCATCACCGCTAGAGTTGATGTCGATACTCAAGATTTACTCGCTAAGGCTGCTGCTCTTGC
TGGTATGTCTAGTATTAACTCATTTGTTTTGAATGCAGCAATCGAAAAAGCAAAACAAGTCATTGAACGTGAGCAAGCTC
TAAAGCTTAGCCAAGCTGATGCCGTATTGCTGATGGAAGCTCTTGATAATCCAGCTGTAGTAAATGCAAAGCTCAAATTG
GCATCCGAACGTTATGAGAGCAAAACTCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

Loading, please wait
Source
ID
Structure
AlphaFold DBA0A0Q0KGB1

Antitoxin

Loading, please wait
Source
ID
Structure
PDB1Y9B
AlphaFold DBA0A0F2IC79

References