Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 758749..759287 Replicon chromosome
Accession NZ_CP102928
Organism Vibrio cholerae strain N1252

Toxin (Protein)


Gene name parE Uniprot ID Q9KMJ0
Locus tag NW313_RS17405 Protein ID WP_000802136.1
Coordinates 758749..759048 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P58093
Locus tag NW313_RS17410 Protein ID WP_001107719.1
Coordinates 759045..759287 (-) Length 81 a.a.

Genomic Context

NW313_RS17360NW313_RS17365NW313_RS17370NW313_RS17375NW313_RS17380NW313_RS17385NW313_RS17390NW313_RS17395NW313_RS17400NW313_RS17415NW313_RS17420NW313_RS17425NW313_RS17430NW313_RS17435NW313_RS17440NW313_RS17445NW313_RS17405NW313_RS17410
Location: 754486..754623 (138 bp)
Type: Others
Protein ID: WP_001890145.1
Location: 754684..754866 (183 bp)
Type: Others
Protein ID: WP_000923182.1
Location: 755066..755539 (474 bp)
Type: Others
Protein ID: WP_001161076.1
Location: 755554..755646 (93 bp)
Type: Others
Protein ID: WP_014378730.1
Location: 755688..756314 (627 bp)
Type: Others
Protein ID: WP_000365424.1
Location: 756437..757135 (699 bp)
Type: Others
Protein ID: WP_001890502.1
Location: 757166..757255 (90 bp)
Type: Others
Protein ID: WP_072606010.1
Location: 757833..758012 (180 bp)
Type: Others
Protein ID: WP_001883058.1
Location: 758226..758621 (396 bp)
Type: Others
Protein ID: WP_000870857.1
Location: 759516..760094 (579 bp)
Type: Others
Protein ID: WP_000110120.1
Location: 760116..760208 (93 bp)
Type: Others
Protein ID: WP_014164112.1
Location: 760632..761315 (684 bp)
Type: Others
Protein ID: WP_000877436.1
Location: 761529..761795 (267 bp)
Type: Others
Protein ID: WP_000937852.1
Location: 761950..762549 (600 bp)
Type: Others
Protein ID: WP_000429495.1
Location: 762830..763765 (936 bp)
Type: Others
Protein ID: WP_000051985.1
Location: 763731..763871 (141 bp)
Type: Others
Protein ID: WP_001883049.1
Location: 758749..759048 (300 bp)
Type: Toxin
Protein ID: WP_000802136.1
Location: 759045..759287 (243 bp)
Type: Antitoxin
Protein ID: WP_001107719.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
NW313_RS17360754486..754623+138WP_001890145.1hypothetical protein-
NW313_RS17365754684..754866+183WP_000923182.1DUF645 family protein-
NW313_RS17370755066..755539+474WP_001161076.1GrpB family protein-
NW313_RS17375755554..755646+93WP_014378730.1DUF3265 domain-containing protein-
NW313_RS17380755688..756314+627WP_000365424.1LysE family translocator-
NW313_RS17385756437..757135+699WP_001890502.1hypothetical protein-
NW313_RS17390757166..757255+90WP_072606010.1DUF3265 domain-containing protein-
NW313_RS17395757833..758012+180WP_001883058.1DUF645 family protein-
NW313_RS17400758226..758621+396WP_000870857.1DUF3465 domain-containing protein-
NW313_RS17405758749..759048-300WP_000802136.1type II toxin-antitoxin system RelE/ParE family toxinToxin
NW313_RS17410759045..759287-243WP_001107719.1type II toxin-antitoxin system ParD family antitoxinAntitoxin
NW313_RS17415759516..760094+579WP_000110120.1hypothetical protein-
NW313_RS17420760116..760208+93WP_014164112.1DUF3265 domain-containing protein-
NW313_RS17425760632..761315+684WP_000877436.1hypothetical protein-
NW313_RS17430761529..761795+267WP_000937852.1hypothetical protein-
NW313_RS17435761950..762549+600WP_000429495.1DUF6338 family protein-
NW313_RS17440762830..763765+936WP_000051985.1restriction endonuclease-
NW313_RS17445763731..763871+141WP_001883049.1DUF3265 domain-containing protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-713852..820357106505
insideIntegroncatB9-718932..819981101049


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-92)

Antitoxin

Antitoxin ParD

(1-79)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11589.29 Da        Isoelectric Point: 9.9232

>T254470 WP_000802136.1 NZ_CP102928:c759048-758749 [Vibrio cholerae]
MKPFNLTVAAKADLRDIALFTQRRWGKEQRNVYLKQFDDSFWLLAENPDIGKSCDEIREGYRKFPQGSHVIFYQQTGSQQ
IRVIRILHKSMDVNPIFGA

Download         Length: 300 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8964.84 Da        Isoelectric Point: 4.1677

>AT254470 WP_001107719.1 NZ_CP102928:c759287-759045 [Vibrio cholerae]
MAKNTSITLGEHFDGFITSQIQSGRYGSASEVIRSALRLLENQETKLQSLRQLLIEGEQSGDADYDLDSFINELDSENIR

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
PDB7R5A

Antitoxin

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Source
ID
Structure
PDB7R5A
PDB7B22
AlphaFold DBA0A151JFU4

References