254470

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 758749..759287 Replicon chromosome
Accession NZ_CP102928
Organism Vibrio cholerae strain N1252

Toxin (Protein)


Gene name parE Uniprot ID Q9KMJ0
Locus tag NW313_RS17405 Protein ID WP_000802136.1
Coordinates 758749..759048 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P58093
Locus tag NW313_RS17410 Protein ID WP_001107719.1
Coordinates 759045..759287 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NW313_RS17360 754486..754623 + 138 WP_001890145.1 hypothetical protein -
NW313_RS17365 754684..754866 + 183 WP_000923182.1 DUF645 family protein -
NW313_RS17370 755066..755539 + 474 WP_001161076.1 GrpB family protein -
NW313_RS17375 755554..755646 + 93 WP_014378730.1 DUF3265 domain-containing protein -
NW313_RS17380 755688..756314 + 627 WP_000365424.1 LysE family translocator -
NW313_RS17385 756437..757135 + 699 WP_001890502.1 hypothetical protein -
NW313_RS17390 757166..757255 + 90 WP_072606010.1 DUF3265 domain-containing protein -
NW313_RS17395 757833..758012 + 180 WP_001883058.1 DUF645 family protein -
NW313_RS17400 758226..758621 + 396 WP_000870857.1 DUF3465 domain-containing protein -
NW313_RS17405 758749..759048 - 300 WP_000802136.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NW313_RS17410 759045..759287 - 243 WP_001107719.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
NW313_RS17415 759516..760094 + 579 WP_000110120.1 hypothetical protein -
NW313_RS17420 760116..760208 + 93 WP_014164112.1 DUF3265 domain-containing protein -
NW313_RS17425 760632..761315 + 684 WP_000877436.1 hypothetical protein -
NW313_RS17430 761529..761795 + 267 WP_000937852.1 hypothetical protein -
NW313_RS17435 761950..762549 + 600 WP_000429495.1 DUF6338 family protein -
NW313_RS17440 762830..763765 + 936 WP_000051985.1 restriction endonuclease -
NW313_RS17445 763731..763871 + 141 WP_001883049.1 DUF3265 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 713852..820357 106505
inside Integron catB9 - 718932..819981 101049


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-92)

Antitoxin

Antitoxin ParD

(1-79)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11589.29 Da        Isoelectric Point: 9.9232

>T254470 WP_000802136.1 NZ_CP102928:c759048-758749 [Vibrio cholerae]
MKPFNLTVAAKADLRDIALFTQRRWGKEQRNVYLKQFDDSFWLLAENPDIGKSCDEIREGYRKFPQGSHVIFYQQTGSQQ
IRVIRILHKSMDVNPIFGA

Download         Length: 300 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8964.84 Da        Isoelectric Point: 4.1677

>AT254470 WP_001107719.1 NZ_CP102928:c759287-759045 [Vibrio cholerae]
MAKNTSITLGEHFDGFITSQIQSGRYGSASEVIRSALRLLENQETKLQSLRQLLIEGEQSGDADYDLDSFINELDSENIR

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7R5A

Antitoxin

Source ID Structure
AlphaFold DB A0A151JFU4

References