211913

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-MqsA
Location 952861..953494 Replicon chromosome
Accession NZ_CP080466
Organism Vibrio cholerae strain ICDC-VC3741

Toxin (Protein)


Gene name higB Uniprot ID Q9KMA6
Locus tag K1T75_RS17955 Protein ID WP_000843587.1
Coordinates 953162..953494 (-) Length 111 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag K1T75_RS17950 Protein ID WP_000071008.1
Coordinates 952861..953175 (-) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K1T75_RS17905 947915..948202 - 288 WP_000221354.1 type II toxin-antitoxin system RelE/ParE family toxin -
K1T75_RS17910 948192..948443 - 252 WP_001250179.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
K1T75_RS17915 948657..949070 - 414 WP_000049417.1 VOC family protein -
K1T75_RS18860 949145..949255 - 111 WP_082798255.1 DUF3265 domain-containing protein -
K1T75_RS17920 949258..949659 - 402 WP_000351248.1 type II toxin-antitoxin system death-on-curing family toxin -
K1T75_RS18865 949659..949829 - 171 WP_001080654.1 hypothetical protein -
K1T75_RS18870 949953..950351 - 399 Protein_834 GNAT family N-acetyltransferase -
K1T75_RS17930 950488..950794 - 307 Protein_835 CatB-related O-acetyltransferase -
K1T75_RS17935 950862..951842 + 981 WP_000019370.1 IS5-like element ISVch5 family transposase -
K1T75_RS17940 951967..952122 - 156 WP_000751734.1 hypothetical protein -
K1T75_RS17945 952290..952724 - 435 WP_000256036.1 GNAT family N-acetyltransferase -
K1T75_RS17950 952861..953175 - 315 WP_000071008.1 DNA-binding transcriptional regulator Antitoxin
K1T75_RS17955 953162..953494 - 333 WP_000843587.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K1T75_RS17960 953835..954062 - 228 WP_001894457.1 DUF1289 domain-containing protein -
K1T75_RS17965 954011..954124 - 114 WP_001889158.1 hypothetical protein -
K1T75_RS17970 954290..954511 - 222 WP_032468461.1 DUF1289 domain-containing protein -
K1T75_RS17975 954520..954634 - 115 Protein_844 acetyltransferase -
K1T75_RS17980 954691..955068 - 378 WP_000411109.1 hypothetical protein -
K1T75_RS17985 955239..955481 - 243 WP_000107461.1 hypothetical protein -
K1T75_RS17990 955683..956069 - 387 WP_000703163.1 VOC family protein -
K1T75_RS17995 956278..956410 - 133 Protein_848 DUF645 family protein -
K1T75_RS18875 956401..956526 - 126 WP_080360924.1 general secretion pathway protein GspH -
K1T75_RS18000 956767..957036 - 270 WP_001198131.1 hypothetical protein -
K1T75_RS18005 957396..957593 - 198 WP_001894451.1 DUF3709 domain-containing protein -
K1T75_RS18010 957850..958053 - 204 WP_001911745.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 932680..1039634 106954
inside Integron - - 933056..1032792 99736
flank IS/Tn - - 950862..951842 980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(4-100)

Antitoxin

Cro/C1-type helix-turn-helix domain

(43-92)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 13005.95 Da        Isoelectric Point: 9.9244

>T211913 WP_000843587.1 NZ_CP080466:c953494-953162 [Vibrio cholerae]
MKSVFVESTIFEKYRDEYLSDEEYRLFQAELMLNPKLGDVIQGTGGLRKIRVASKGKGKRGGSRIIYYFLDEKRRFYLLT
IYGKNEMSDLNANQRKQLMAFMEAWRNEQS

Download         Length: 333 bp

>T211913 NZ_CP106839:c125023-124739 [Klebsiella michiganensis]
ATGACCTATAAGCTGGCCTTTAATGAATCAGCTCTGAAAGAATGGAAAAAGTTGGGCCATACCATTCGTGAACAATTCAA
AAAGAAGCTCGCTGAGCGCCTGTTGAACTCACGGGTGCCCGCATCGCAACTCCATGGACGCCAAGACCAGTACAAAATTA
AGCTCTGTGGCGCAGGCTGCCGACTGGTATACAGTGTCAACGATGATGTTGTGACGGTCACCGTAATTGGCGTCGGTAAA
CGTGAAAATGATGATATCTACAATTTGACCAAACACAGAAATTAA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 11696.20 Da        Isoelectric Point: 6.7600

>AT211913 WP_000071008.1 NZ_CP080466:c953175-952861 [Vibrio cholerae]
MSNRDLFAELSSALVEAKQHSEGKLTLKTHHVNDVGELNISPDEIVSIREQFNMSRGVFARLLHTSSRTLENWEQGRSVP
NGQAVTLLKLVQRHPETLSHIAEL

Download         Length: 315 bp

>AT211913 NZ_CP106839:c125261-125013 [Klebsiella michiganensis]
ATGGCATTTCAGATTCTAACCACTACTGCGGCAAGCATCACGGAGCTTAAACGTGATCCTATGGGCACTTTCAATGCAGG
AGAAGGTGCCCCAGTAGCCATACTGAATCGCAACGAACCCGCTTTTTACTGTGTACCGCCTGCTCTGTATGCTCAACTGA
TGGAGCTTTTTGAAGATCAGGAGTTGGGTCGTATTGCTGATGAGCGAATTGGTGAGGCATTAATCGAGGTCAGGATTGAT
GACCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5JA9
PDB 8A0X
PDB 5MJE
PDB 5JA8
PDB 5JAA

Antitoxin

Source ID Structure

References