Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
| Location | 360378..360993 | Replicon | chromosome |
| Accession | NZ_CP072850 | ||
| Organism | Vibrio cholerae MO10 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | Q9KMG5 |
| Locus tag | KAF59_RS15585 | Protein ID | WP_001162670.1 |
| Coordinates | 360378..360665 (+) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | KAF59_RS15590 | Protein ID | WP_001232701.1 |
| Coordinates | 360676..360993 (+) | Length | 106 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KAF59_RS18860 | 355721..355896 | + | 176 | Protein_347 | acetyltransferase | - |
| KAF59_RS18865 | 355957..356109 | + | 153 | Protein_348 | DUF645 family protein | - |
| KAF59_RS15550 (KAF59_15550) | 356303..356620 | - | 318 | WP_001180243.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| KAF59_RS15555 (KAF59_15555) | 356639..356881 | - | 243 | WP_000557292.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| KAF59_RS15560 (KAF59_15560) | 357123..357632 | + | 510 | WP_000405987.1 | GNAT family N-acetyltransferase | - |
| KAF59_RS15565 (KAF59_15565) | 357689..358342 | + | 654 | WP_000226874.1 | hypothetical protein | - |
| KAF59_RS18870 | 358431..358640 | + | 210 | WP_001900246.1 | DUF3709 domain-containing protein | - |
| KAF59_RS15570 (KAF59_15570) | 358652..358870 | + | 219 | WP_001917086.1 | DUF3709 domain-containing protein | - |
| KAF59_RS18875 | 359059..359252 | + | 194 | Protein_355 | hypothetical protein | - |
| KAF59_RS15575 (KAF59_15575) | 359273..359506 | + | 234 | WP_032482776.1 | DUF3709 domain-containing protein | - |
| KAF59_RS15580 (KAF59_15580) | 359931..360111 | + | 181 | Protein_357 | DUF645 family protein | - |
| KAF59_RS18880 | 360224..360337 | + | 114 | WP_001894955.1 | hypothetical protein | - |
| KAF59_RS15585 (KAF59_15585) | 360378..360665 | + | 288 | WP_001162670.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| KAF59_RS15590 (KAF59_15590) | 360676..360993 | + | 318 | WP_001232701.1 | HigA family addiction module antitoxin | Antitoxin |
| KAF59_RS15595 (KAF59_15595) | 360990..361100 | + | 111 | WP_134814058.1 | DUF3265 domain-containing protein | - |
| KAF59_RS18885 | 361139..361249 | + | 111 | Protein_362 | acetyltransferase | - |
| KAF59_RS15600 (KAF59_15600) | 361277..361402 | + | 126 | WP_001944767.1 | DUF645 family protein | - |
| KAF59_RS18890 | 361365..361481 | + | 117 | WP_001889170.1 | hypothetical protein | - |
| KAF59_RS15610 (KAF59_15610) | 361669..362673 | + | 1005 | WP_000964925.1 | LD-carboxypeptidase | - |
| KAF59_RS15615 (KAF59_15615) | 362826..363272 | + | 447 | WP_000128977.1 | hypothetical protein | - |
| KAF59_RS15620 (KAF59_15620) | 363392..364321 | + | 930 | WP_000335802.1 | hypothetical protein | - |
| KAF59_RS15625 (KAF59_15625) | 364318..364428 | + | 111 | WP_071917832.1 | DUF3265 domain-containing protein | - |
| KAF59_RS15630 (KAF59_15630) | 364456..364932 | + | 477 | WP_001047180.1 | GNAT family N-acetyltransferase | - |
| KAF59_RS15635 (KAF59_15635) | 365123..365584 | + | 462 | WP_001911752.1 | lipocalin family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | catB9 | - | 306928..402189 | 95261 | |
| inside | Integron | catB9 | - | 312008..401813 | 89805 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11349.95 Da Isoelectric Point: 6.7187
>T199004 WP_001162670.1 NZ_CP072850:360378-360665 [Vibrio cholerae MO10]
MALEFKDKWLEQFYEDDKRHRLIPSSIENALFRKLEILDAAQAESDLRIPPGNRFEHLEGNLKGWCSIRVNKQYRLIFQW
VDGVALNTYLDPHKY
MALEFKDKWLEQFYEDDKRHRLIPSSIENALFRKLEILDAAQAESDLRIPPGNRFEHLEGNLKGWCSIRVNKQYRLIFQW
VDGVALNTYLDPHKY
Download Length: 288 bp
>T199004 NZ_CP097093:156995-157276 [Mogibacterium diversum]
ATGAAGTATTCAATTAAGTTTACAAGCCAGTTTAAAAAAGATTTAAAATTAGCAAAAAAACAAGGAAAAAATTTAAATAA
GCTGTTTGAGGTTGTGGATGCTCTCGCTACAGGCAAAACACTTGAGGCAAAGTATCGTGACCACAATTTATCTGGTAAGT
ATTCAGCTACAAGAGAATGTCACATTGAGCCAGACTGGCTATTGGTATATGAGATAATTGATGAATCTCTTGTGCTGATA
TTATATAGGATTGGATCGCATGCGAAATTATTTAAATTGTAA
ATGAAGTATTCAATTAAGTTTACAAGCCAGTTTAAAAAAGATTTAAAATTAGCAAAAAAACAAGGAAAAAATTTAAATAA
GCTGTTTGAGGTTGTGGATGCTCTCGCTACAGGCAAAACACTTGAGGCAAAGTATCGTGACCACAATTTATCTGGTAAGT
ATTCAGCTACAAGAGAATGTCACATTGAGCCAGACTGGCTATTGGTATATGAGATAATTGATGAATCTCTTGTGCTGATA
TTATATAGGATTGGATCGCATGCGAAATTATTTAAATTGTAA
Antitoxin
Download Length: 106 a.a. Molecular weight: 11705.63 Da Isoelectric Point: 10.4711
>AT199004 WP_001232701.1 NZ_CP072850:360676-360993 [Vibrio cholerae MO10]
MRKTKRRPVSVGEMLKVEFLEPMGITSKALAEAMGVHRNTVSNLINGGVLTAPVAIKLAAALGNTPEFWLNIQHAVDLWD
TRNRYQEEAKFVKPLFVSLEQSART
MRKTKRRPVSVGEMLKVEFLEPMGITSKALAEAMGVHRNTVSNLINGGVLTAPVAIKLAAALGNTPEFWLNIQHAVDLWD
TRNRYQEEAKFVKPLFVSLEQSART
Download Length: 318 bp
>AT199004 NZ_CP097093:156726-156998 [Mogibacterium diversum]
ATGCCATCTACAAATTTAAATATTAGAACAGAAAAAGAAGTAAAAGAAAAAGCGGATCAAATATTCTCAGAACTTGGATT
GAATATGACTACGGCAATTAACATTTTTCTGCGCACAGCTATTCGTGAACATGGAATACCATTCTCTTTAAAACTAGATA
TTCCAAATGAAGCTACTGTTAATGCGATAGAGGAAGGGAGAAGAATTGCTTTTGATAAAAGTGCTGAAAGCTATTCCAAT
ATTGATGAGCTTAAGGCGGCTTTAGATATATGA
ATGCCATCTACAAATTTAAATATTAGAACAGAAAAAGAAGTAAAAGAAAAAGCGGATCAAATATTCTCAGAACTTGGATT
GAATATGACTACGGCAATTAACATTTTTCTGCGCACAGCTATTCGTGAACATGGAATACCATTCTCTTTAAAACTAGATA
TTCCAAATGAAGCTACTGTTAATGCGATAGAGGAAGGGAGAAGAATTGCTTTTGATAAAAGTGCTGAAAGCTATTCCAAT
ATTGATGAGCTTAAGGCGGCTTTAGATATATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|