145823

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-Phd
Location 323541..324119 Replicon chromosome
Accession NZ_CP047298
Organism Vibrio cholerae O1 biovar El Tor strain C6709

Toxin (Protein)


Gene name parE Uniprot ID O68848
Locus tag GTF73_RS15175 Protein ID WP_001180243.1
Coordinates 323541..323858 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q7DCR7
Locus tag GTF73_RS15180 Protein ID WP_000557292.1
Coordinates 323877..324119 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GTF73_RS15145 319065..319247 + 183 WP_000923340.1 DUF645 family protein -
GTF73_RS15150 319601..319783 + 183 WP_000923153.1 DUF645 family protein -
GTF73_RS15155 319978..320655 + 678 WP_000254617.1 HNH endonuclease -
GTF73_RS15160 320817..322025 + 1209 WP_000272282.1 deoxyguanosinetriphosphate triphosphohydrolase family protein -
GTF73_RS15165 322187..322891 + 705 WP_000087610.1 HNH endonuclease -
GTF73_RS15170 323049..323387 + 339 WP_000713853.1 hypothetical protein -
GTF73_RS15175 323541..323858 - 318 WP_001180243.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GTF73_RS15180 323877..324119 - 243 WP_000557292.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
GTF73_RS15185 324363..324749 + 387 WP_001015867.1 NUDIX hydrolase -
GTF73_RS15190 324806..324919 + 114 WP_001900214.1 hypothetical protein -
GTF73_RS15195 324868..325149 + 282 WP_001894429.1 DUF1289 domain-containing protein -
GTF73_RS15200 325125..325283 - 159 WP_001886450.1 DUF1196 family protein -
GTF73_RS15205 325407..325943 + 537 WP_000469482.1 GNAT family N-acetyltransferase -
GTF73_RS15210 326080..326595 + 516 WP_001201509.1 lipocalin family protein -
GTF73_RS15215 326745..327242 - 498 WP_000982260.1 GNAT family N-acetyltransferase -
GTF73_RS15220 327239..327511 - 273 WP_000246253.1 DUF1778 domain-containing protein -
GTF73_RS15225 327904..328029 + 126 WP_001900195.1 DUF645 family protein -
GTF73_RS15230 328045..328083 + 39 WP_106019118.1 hypothetical protein -
GTF73_RS15235 328279..328725 + 447 WP_000006157.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 306901..436162 129261
inside Integron - - 311981..435786 123805


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-93)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-71)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12158.97 Da        Isoelectric Point: 9.7495

>T145823 WP_001180243.1 NZ_CP047298:c323858-323541 [Vibrio cholerae O1 biovar El Tor]
MQNKQYKLSQLAQEHLLKIKHYTIENFAEAQWQKYKSTLLSGFQTLADNPGLGKSCEDIYQNGFYFPVGKHMAYYTKEAN
FILIVAVLGQSQLPQKHLKQSRFVS

Download         Length: 318 bp

>T145823 NZ_CP062700:4454400-4454660 [Escherichia coli O157:H7]
TTGAACTCGGGACAATTTTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAATAAATTGAAATATCTTAT
GACGCTTCTTATCAATAATACTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAGGTTCATGGAAAGGTTATC
GCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGATTTGAGAGAACTGGAACT
CACGCGGCGCTCTTTGGGTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.25 Da        Isoelectric Point: 5.6630

>AT145823 WP_000557292.1 NZ_CP047298:c324119-323877 [Vibrio cholerae O1 biovar El Tor]
MHTLTANDAKRNFGELLLSAQREPVIISKNSKNTVVVMSIKDFEELEAMKLDYLKHCFESAQKDLDSGKTVDGATFLNTL

Download         Length: 243 bp

>AT145823 NZ_CP062700:4454121-4454381 [Escherichia coli O157:H7]
ATGGCTGCTAACGCATTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCGGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCGTTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0K9UJR8

Antitoxin

Source ID Structure
AlphaFold DB Q7DCR7

References