Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DhiAT/-
Location 458829..459613 Replicon chromosome
Accession NZ_CP013306
Organism Vibrio cholerae strain CRC1106

Toxin (Protein)


Gene name dhiT Uniprot ID A0A086SLD6
Locus tag ASZ81_RS17090 Protein ID WP_001114075.1
Coordinates 458829..459098 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name dhiA Uniprot ID Q9KM84
Locus tag ASZ81_RS17095 Protein ID WP_000921691.1
Coordinates 459092..459613 (+) Length 174 a.a.

Genomic Context

ASZ81_RS17045ASZ81_RS17055ASZ81_RS17060ASZ81_RS17065ASZ81_RS17070ASZ81_RS17080ASZ81_RS17085ASZ81_RS20690ASZ81_RS17090ASZ81_RS17095ASZ81_RS20695ASZ81_RS17110ASZ81_RS17125ASZ81_RS17130ASZ81_RS17145ASZ81_RS17115ASZ81_RS17120
Location: 454196..455113 (918 bp)
Type: Others
Protein ID: WP_000186333.1
Location: 455270..455659 (390 bp)
Type: Others
Protein ID: WP_001081302.1
Location: 455795..456004 (210 bp)
Type: Others
Protein ID: Protein_514
Location: 456123..456560 (438 bp)
Type: Others
Protein ID: WP_000503169.1
Location: 456624..456842 (219 bp)
Type: Others
Protein ID: WP_071908318.1
Location: 457017..457889 (873 bp)
Type: Others
Protein ID: WP_000254716.1
Location: 458038..458637 (600 bp)
Type: Others
Protein ID: WP_001891245.1
Location: 458694..458798 (105 bp)
Type: Others
Protein ID: WP_099607150.1
Location: 458829..459098 (270 bp)
Type: Toxin
Protein ID: WP_001114075.1
Location: 459092..459613 (522 bp)
Type: Antitoxin
Protein ID: WP_000921691.1
Location: 459912..460037 (126 bp)
Type: Others
Protein ID: WP_001905700.1
Location: 460288..460683 (396 bp)
Type: Others
Protein ID: WP_001000867.1
Location: 461575..462090 (516 bp)
Type: Others
Protein ID: WP_000343779.1
Location: 462274..462687 (414 bp)
Type: Others
Protein ID: WP_000049420.1
Location: 463242..464419 (1178 bp)
Type: Others
Protein ID: WP_086010879.1
Location: 460822..461100 (279 bp)
Type: Others
Protein ID: WP_000578476.1
Location: 461097..461381 (285 bp)
Type: Others
Protein ID: WP_000381183.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
ASZ81_RS17045454196..455113+918WP_000186333.1alpha/beta hydrolase-
ASZ81_RS17055455270..455659+390WP_001081302.1hypothetical protein-
ASZ81_RS17060455795..456004+210Protein_514GNAT family N-acetyltransferase-
ASZ81_RS17065456123..456560+438WP_000503169.1IS200/IS605-like element IS1004 family transposase-
ASZ81_RS17070456624..456842+219WP_071908318.1GNAT family N-acetyltransferase-
ASZ81_RS17080457017..457889+873WP_000254716.1DUF3800 domain-containing protein-
ASZ81_RS17085458038..458637+600WP_001891245.1glutathione S-transferase N-terminal domain-containing protein-
ASZ81_RS20690458694..458798+105WP_099607150.1acetyltransferase-
ASZ81_RS17090458829..459098+270WP_001114075.1DUF4160 domain-containing proteinToxin
ASZ81_RS17095459092..459613+522WP_000921691.1DUF2442 domain-containing proteinAntitoxin
ASZ81_RS20695459912..460037+126WP_001905700.1DUF645 family protein-
ASZ81_RS17110460288..460683+396WP_001000867.1hypothetical protein-
ASZ81_RS17115460822..461100-279WP_000578476.1type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family-
ASZ81_RS17120461097..461381-285WP_000381183.1type II toxin-antitoxin system RelB/DinJ family antitoxin-
ASZ81_RS17125461575..462090+516WP_000343779.1GNAT family N-acetyltransferase-
ASZ81_RS17130462274..462687+414WP_000049420.1VOC family protein-
ASZ81_RS17145463242..464419+1178WP_086010879.1IS3-like element ISVch4 family transposase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-304741..463550158809
insideIntegron--309821..463174153353
flankIS/Tn--456123..456560437


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF4160

(9-74)

Antitoxin

Protein of unknown function DUF2442

(4-59)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10310.94 Da        Isoelectric Point: 6.6303

>T58279 WP_001114075.1 NZ_CP013306:458829-459098 [Vibrio cholerae]
MPEIDALLGLSFCLYFFDNKQHKLPHIHVKYGSYELIIAIETGECLEGYLPNKQRKRAENHILEHREQLMVMWNKAVNGE
NPGKLGDLC

Download         Length: 270 bp

>T58279 NZ_CP013306:458829-459098 [Vibrio cholerae]
ATGCCAGAGATTGATGCCCTATTAGGTCTTTCATTTTGCTTGTACTTCTTTGATAACAAGCAGCATAAATTACCTCATAT
TCACGTTAAGTACGGTAGTTACGAGCTAATTATTGCTATTGAAACAGGTGAGTGTTTAGAGGGTTACTTACCCAATAAGC
AACGAAAACGTGCTGAAAACCATATTCTTGAACATCGAGAGCAATTGATGGTGATGTGGAATAAAGCGGTGAATGGTGAA
AATCCAGGTAAGTTAGGTGATTTATGTTGA

Antitoxin


Download         Length: 174 a.a.        Molecular weight: 19409.01 Da        Isoelectric Point: 6.7342

>AT58279 WP_000921691.1 NZ_CP013306:459092-459613 [Vibrio cholerae]
MLKVIDVDFVSDHTLELTFNDGYQGYADLSVYFKKAPFSEIKDFKRFSLTRDGSLNWDGNELTAATLRDITKGSQKSVEL
SFNVQEMEAVIKQASWESMMEGRPDILQAAIRSYVEQFGHGQVIAKAGIKSRTSAYRSLKPETTPNFGTLVQLGHAVIEL
AKDRTVANKEPRI

Download         Length: 522 bp

>AT58279 NZ_CP013306:459092-459613 [Vibrio cholerae]
ATGTTGAAAGTCATAGATGTTGATTTTGTCTCAGACCATACATTAGAACTGACGTTCAATGATGGTTACCAAGGCTATGC
CGACTTGTCGGTATACTTTAAAAAAGCACCGTTTTCAGAAATTAAGGACTTTAAACGCTTTTCCTTGACTCGTGATGGCT
CGTTAAATTGGGATGGTAATGAGTTAACGGCCGCGACACTCCGTGACATAACCAAGGGCTCACAAAAGTCGGTGGAGTTA
AGTTTTAATGTTCAAGAAATGGAAGCCGTCATCAAACAGGCCTCATGGGAATCGATGATGGAGGGGCGTCCCGACATCTT
GCAAGCGGCTATTCGTTCTTACGTAGAGCAGTTTGGTCATGGTCAAGTTATTGCAAAGGCGGGTATAAAAAGTCGTACGA
GTGCTTATCGCTCCTTGAAGCCAGAAACAACGCCAAACTTTGGCACACTAGTTCAGTTAGGGCACGCCGTCATCGAACTA
GCGAAAGATAGAACAGTGGCAAACAAGGAACCACGCATATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A086SLD6

Antitoxin

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Source
ID
Structure
AlphaFold DBQ9KM84

References