23781

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-Phd
Location 960073..960620 Replicon chromosome
Accession NC_012667
Organism Vibrio cholerae MJ-1236

Toxin (Protein)


Gene name relE Uniprot ID Q9KM92
Locus tag VCD_RS18910 Protein ID WP_000229317.1
Coordinates 960073..960375 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9KM93
Locus tag VCD_RS18915 Protein ID WP_000861987.1
Coordinates 960363..960620 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
VCD_RS18885 955642..955977 + 336 WP_000978439.1 hypothetical protein -
VCD_RS18890 955974..957722 + 1749 WP_000063385.1 hypothetical protein -
VCD_RS18895 957722..958180 + 459 WP_001176612.1 hypothetical protein -
VCD_RS18900 958376..958765 - 390 WP_001081302.1 hypothetical protein -
VCD_RS18905 958922..959839 - 918 WP_000186333.1 alpha/beta hydrolase -
VCD_RS18910 960073..960375 - 303 WP_000229317.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
VCD_RS18915 960363..960620 - 258 WP_000861987.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
VCD_RS18920 960822..961355 - 534 WP_000118351.1 GNAT family N-acetyltransferase -
VCD_RS21060 961352..961777 - 426 WP_001882332.1 DUF1778 domain-containing protein -
VCD_RS18930 961844..962215 - 372 WP_001164080.1 nucleotide pyrophosphohydrolase -
VCD_RS18935 962356..962643 - 288 WP_000426470.1 hypothetical protein -
VCD_RS18940 962795..963463 - 669 WP_000043871.1 hypothetical protein -
VCD_RS18945 963694..963966 + 273 WP_000246253.1 DUF1778 domain-containing protein -
VCD_RS18950 963963..964460 + 498 WP_000982260.1 GNAT family N-acetyltransferase -
VCD_RS18955 964662..964814 - 153 WP_001884520.1 DUF645 family protein -
VCD_RS18960 965136..965591 - 456 WP_001245327.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 932253..1057432 125179
inside Integron - - 958376..1050596 92220


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-69)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11726.68 Da        Isoelectric Point: 5.1972

>T23781 WP_000229317.1 NC_012667:c960375-960073 [Vibrio cholerae MJ-1236]
MVEIIWTELALSDLNDIAEYIALENVVAAKQLVQTVFTKVERLADFPESGRVPPELEHLNYREVVVSPCRVFYKYDDAKV
RILFVMRAERDLRRLMLTKQ

Download         Length: 303 bp

>T23781 NC_012667:c960375-960073 [Vibrio cholerae MJ-1236]
ATGGTTGAAATAATTTGGACGGAGCTGGCTCTATCCGACTTGAATGATATTGCTGAATACATCGCGCTTGAAAATGTCGT
GGCTGCTAAACAACTGGTGCAAACCGTTTTTACAAAAGTTGAACGTTTGGCCGATTTTCCAGAGTCTGGGCGCGTCCCTC
CAGAACTAGAACACCTCAATTATCGTGAAGTCGTTGTAAGTCCGTGTCGTGTTTTCTACAAGTATGATGATGCAAAGGTT
CGTATTCTTTTTGTTATGCGTGCGGAGCGAGATTTGCGTCGGTTAATGCTTACGAAACAGTAG

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9647.15 Da        Isoelectric Point: 7.3178

>AT23781 WP_000861987.1 NC_012667:c960620-960363 [Vibrio cholerae MJ-1236]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLIDVDDYEFMQNRLAILEGIARGERALADGKVVSHQDAKDRM
SKWLK

Download         Length: 258 bp

>AT23781 NC_012667:c960620-960363 [Vibrio cholerae MJ-1236]
ATGAAAGTAGAACTTGTGACGTCACTAAAACGTCAGGCCACTAAGATCCTTGCCGATCTTCATGATACGAAAGAGCCAGT
ATTGATAACTGAGCACGGAAAACCGTCAGCTTACCTTATTGATGTAGACGACTATGAATTTATGCAAAATCGTTTAGCGA
TCCTGGAAGGTATTGCTCGCGGAGAGCGAGCTTTAGCGGATGGTAAAGTGGTCAGCCATCAAGATGCTAAGGACAGAATG
TCAAAATGGTTGAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q9KM92

Antitoxin

Source ID Structure
AlphaFold DB A0A1T4SLM9

References