Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-Phd
Location 960073..960620 Replicon chromosome
Accession NC_012667
Organism Vibrio cholerae MJ-1236

Toxin (Protein)


Gene name relE Uniprot ID Q9KM92
Locus tag VCD_RS18910 Protein ID WP_000229317.1
Coordinates 960073..960375 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9KM93
Locus tag VCD_RS18915 Protein ID WP_000861987.1
Coordinates 960363..960620 (-) Length 86 a.a.

Genomic Context

VCD_RS18885VCD_RS18890VCD_RS18895VCD_RS18945VCD_RS18950VCD_RS18900VCD_RS18905VCD_RS18910VCD_RS18915VCD_RS18920VCD_RS21060VCD_RS18930VCD_RS18935VCD_RS18940VCD_RS18955VCD_RS18960
Location: 955642..955977 (336 bp)
Type: Others
Protein ID: WP_000978439.1
Location: 955974..957722 (1749 bp)
Type: Others
Protein ID: WP_000063385.1
Location: 957722..958180 (459 bp)
Type: Others
Protein ID: WP_001176612.1
Location: 963694..963966 (273 bp)
Type: Others
Protein ID: WP_000246253.1
Location: 963963..964460 (498 bp)
Type: Others
Protein ID: WP_000982260.1
Location: 958376..958765 (390 bp)
Type: Others
Protein ID: WP_001081302.1
Location: 958922..959839 (918 bp)
Type: Others
Protein ID: WP_000186333.1
Location: 960073..960375 (303 bp)
Type: Toxin
Protein ID: WP_000229317.1
Location: 960363..960620 (258 bp)
Type: Antitoxin
Protein ID: WP_000861987.1
Location: 960822..961355 (534 bp)
Type: Others
Protein ID: WP_000118351.1
Location: 961352..961777 (426 bp)
Type: Others
Protein ID: WP_001882332.1
Location: 961844..962215 (372 bp)
Type: Others
Protein ID: WP_001164080.1
Location: 962356..962643 (288 bp)
Type: Others
Protein ID: WP_000426470.1
Location: 962795..963463 (669 bp)
Type: Others
Protein ID: WP_000043871.1
Location: 964662..964814 (153 bp)
Type: Others
Protein ID: WP_001884520.1
Location: 965136..965591 (456 bp)
Type: Others
Protein ID: WP_001245327.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
VCD_RS18885955642..955977+336WP_000978439.1hypothetical protein-
VCD_RS18890955974..957722+1749WP_000063385.1hypothetical protein-
VCD_RS18895957722..958180+459WP_001176612.1hypothetical protein-
VCD_RS18900958376..958765-390WP_001081302.1hypothetical protein-
VCD_RS18905958922..959839-918WP_000186333.1alpha/beta hydrolase-
VCD_RS18910960073..960375-303WP_000229317.1type II toxin-antitoxin system RelE/ParE family toxinToxin
VCD_RS18915960363..960620-258WP_000861987.1type II toxin-antitoxin system Phd/YefM family antitoxinAntitoxin
VCD_RS18920960822..961355-534WP_000118351.1GNAT family N-acetyltransferase-
VCD_RS21060961352..961777-426WP_001882332.1DUF1778 domain-containing protein-
VCD_RS18930961844..962215-372WP_001164080.1nucleotide pyrophosphohydrolase-
VCD_RS18935962356..962643-288WP_000426470.1hypothetical protein-
VCD_RS18940962795..963463-669WP_000043871.1hypothetical protein-
VCD_RS18945963694..963966+273WP_000246253.1DUF1778 domain-containing protein-
VCD_RS18950963963..964460+498WP_000982260.1GNAT family N-acetyltransferase-
VCD_RS18955964662..964814-153WP_001884520.1DUF645 family protein-
VCD_RS18960965136..965591-456WP_001245327.1GNAT family N-acetyltransferase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-932253..1057432125179
insideIntegron--958376..105059692220


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-69)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11726.68 Da        Isoelectric Point: 5.1972

>T23781 WP_000229317.1 NC_012667:c960375-960073 [Vibrio cholerae MJ-1236]
MVEIIWTELALSDLNDIAEYIALENVVAAKQLVQTVFTKVERLADFPESGRVPPELEHLNYREVVVSPCRVFYKYDDAKV
RILFVMRAERDLRRLMLTKQ

Download         Length: 303 bp

>T23781 NC_012667:c960375-960073 [Vibrio cholerae MJ-1236]
ATGGTTGAAATAATTTGGACGGAGCTGGCTCTATCCGACTTGAATGATATTGCTGAATACATCGCGCTTGAAAATGTCGT
GGCTGCTAAACAACTGGTGCAAACCGTTTTTACAAAAGTTGAACGTTTGGCCGATTTTCCAGAGTCTGGGCGCGTCCCTC
CAGAACTAGAACACCTCAATTATCGTGAAGTCGTTGTAAGTCCGTGTCGTGTTTTCTACAAGTATGATGATGCAAAGGTT
CGTATTCTTTTTGTTATGCGTGCGGAGCGAGATTTGCGTCGGTTAATGCTTACGAAACAGTAG

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9647.15 Da        Isoelectric Point: 7.3178

>AT23781 WP_000861987.1 NC_012667:c960620-960363 [Vibrio cholerae MJ-1236]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLIDVDDYEFMQNRLAILEGIARGERALADGKVVSHQDAKDRM
SKWLK

Download         Length: 258 bp

>AT23781 NC_012667:c960620-960363 [Vibrio cholerae MJ-1236]
ATGAAAGTAGAACTTGTGACGTCACTAAAACGTCAGGCCACTAAGATCCTTGCCGATCTTCATGATACGAAAGAGCCAGT
ATTGATAACTGAGCACGGAAAACCGTCAGCTTACCTTATTGATGTAGACGACTATGAATTTATGCAAAATCGTTTAGCGA
TCCTGGAAGGTATTGCTCGCGGAGAGCGAGCTTTAGCGGATGGTAAAGTGGTCAGCCATCAAGATGCTAAGGACAGAATG
TCAAAATGGTTGAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBQ9KM92

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A1T4SLM9

References