Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-Phd
Location 398051..398629 Replicon chromosome
Accession NZ_CP013314
Organism Vibrio cholerae strain E9120

Toxin (Protein)


Gene name parE Uniprot ID O68848
Locus tag ASZ79_RS16360 Protein ID WP_001180243.1
Coordinates 398051..398368 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q7DCR7
Locus tag ASZ79_RS16365 Protein ID WP_000557292.1
Coordinates 398387..398629 (-) Length 81 a.a.

Genomic Context

ASZ79_RS16310ASZ79_RS16315ASZ79_RS16320ASZ79_RS16325ASZ79_RS16330ASZ79_RS16335ASZ79_RS16340ASZ79_RS20640ASZ79_RS21005ASZ79_RS16370ASZ79_RS16375ASZ79_RS16380ASZ79_RS16390ASZ79_RS16395ASZ79_RS16400ASZ79_RS16405ASZ79_RS21010ASZ79_RS21015ASZ79_RS21020ASZ79_RS16360ASZ79_RS16365
Location: 393242..393637 (396 bp)
Type: Others
Protein ID: WP_000046952.1
Location: 393940..394121 (182 bp)
Type: Others
Protein ID: Protein_402
Location: 394298..394693 (396 bp)
Type: Others
Protein ID: WP_000046953.1
Location: 394837..395373 (537 bp)
Type: Others
Protein ID: WP_000644491.1
Location: 395670..395849 (180 bp)
Type: Others
Protein ID: WP_001883039.1
Location: 396045..396470 (426 bp)
Type: Others
Protein ID: WP_000403014.1
Location: 396619..396966 (348 bp)
Type: Others
Protein ID: WP_000933409.1
Location: 397113..397406 (294 bp)
Type: Others
Protein ID: WP_125460920.1
Location: 397762..397857 (96 bp)
Type: Others
Protein ID: WP_001907607.1
Location: 398871..399380 (510 bp)
Type: Others
Protein ID: WP_000405987.1
Location: 399437..400090 (654 bp)
Type: Others
Protein ID: WP_000226874.1
Location: 400400..400618 (219 bp)
Type: Others
Protein ID: WP_001917086.1
Location: 401021..401254 (234 bp)
Type: Others
Protein ID: WP_032482776.1
Location: 401679..401859 (181 bp)
Type: Others
Protein ID: Protein_416
Location: 402126..402413 (288 bp)
Type: Others
Protein ID: WP_001162670.1
Location: 402424..402741 (318 bp)
Type: Others
Protein ID: WP_001232701.1
Location: 402738..402848 (111 bp)
Type: Others
Protein ID: WP_134814058.1
Location: 403025..403150 (126 bp)
Type: Others
Protein ID: WP_001944767.1
Location: 403166..403204 (39 bp)
Type: Others
Protein ID: WP_106019119.1
Location: 398051..398368 (318 bp)
Type: Toxin
Protein ID: WP_001180243.1
Location: 398387..398629 (243 bp)
Type: Antitoxin
Protein ID: WP_000557292.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
ASZ79_RS16310393242..393637+396WP_000046952.1hypothetical protein-
ASZ79_RS16315393940..394121+182Protein_402DUF645 family protein-
ASZ79_RS16320394298..394693+396WP_000046953.1hypothetical protein-
ASZ79_RS16325394837..395373+537WP_000644491.1nucleotidyltransferase family protein-
ASZ79_RS16330395670..395849+180WP_001883039.1DUF645 family protein-
ASZ79_RS16335396045..396470+426WP_000403014.1GNAT family N-acetyltransferase-
ASZ79_RS16340396619..396966+348WP_000933409.1hypothetical protein-
ASZ79_RS20640397113..397406+294WP_125460920.1hypothetical protein-
ASZ79_RS21005397762..397857+96WP_001907607.1DUF645 family protein-
ASZ79_RS16360398051..398368-318WP_001180243.1type II toxin-antitoxin system RelE/ParE family toxinToxin
ASZ79_RS16365398387..398629-243WP_000557292.1type II toxin-antitoxin system Phd/YefM family antitoxinAntitoxin
ASZ79_RS16370398871..399380+510WP_000405987.1GNAT family N-acetyltransferase-
ASZ79_RS16375399437..400090+654WP_000226874.1hypothetical protein-
ASZ79_RS16380400400..400618+219WP_001917086.1DUF3709 domain-containing protein-
ASZ79_RS16390401021..401254+234WP_032482776.1DUF3709 domain-containing protein-
ASZ79_RS16395401679..401859+181Protein_416DUF645 family protein-
ASZ79_RS16400402126..402413+288WP_001162670.1type II toxin-antitoxin system RelE/ParE family toxin-
ASZ79_RS16405402424..402741+318WP_001232701.1HigA family addiction module antidote protein-
ASZ79_RS21010402738..402848+111WP_134814058.1DUF3265 domain-containing protein-
ASZ79_RS21015403025..403150+126WP_001944767.1DUF645 family protein-
ASZ79_RS21020403166..403204+39WP_106019119.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-304700..468464163764
insideIntegron--309780..468088158308


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-93)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-71)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12158.97 Da        Isoelectric Point: 9.7495

>T58359 WP_001180243.1 NZ_CP013314:c398368-398051 [Vibrio cholerae]
MQNKQYKLSQLAQEHLLKIKHYTIENFAEAQWQKYKSTLLSGFQTLADNPGLGKSCEDIYQNGFYFPVGKHMAYYTKEAN
FILIVAVLGQSQLPQKHLKQSRFVS

Download         Length: 318 bp

>T58359 NZ_CP013314:c398368-398051 [Vibrio cholerae]
ATGCAAAATAAACAATATAAGCTCAGCCAATTAGCCCAAGAGCACTTACTCAAGATTAAACACTACACCATTGAAAATTT
CGCTGAAGCGCAGTGGCAAAAATATAAGTCGACCTTGCTTTCAGGTTTCCAAACTCTTGCGGATAACCCAGGACTAGGAA
AAAGCTGTGAAGATATTTACCAAAATGGTTTTTACTTTCCAGTGGGGAAACACATGGCTTATTACACCAAAGAAGCAAAC
TTCATTCTCATTGTTGCGGTATTAGGGCAATCACAACTGCCCCAAAAGCATCTCAAACAGTCACGCTTTGTTTCTTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.25 Da        Isoelectric Point: 5.6630

>AT58359 WP_000557292.1 NZ_CP013314:c398629-398387 [Vibrio cholerae]
MHTLTANDAKRNFGELLLSAQREPVIISKNSKNTVVVMSIKDFEELEAMKLDYLKHCFESAQKDLDSGKTVDGATFLNTL

Download         Length: 243 bp

>AT58359 NZ_CP013314:c398629-398387 [Vibrio cholerae]
ATGCACACACTAACAGCAAATGATGCTAAACGAAATTTTGGTGAACTTCTTCTAAGCGCACAACGCGAACCTGTCATCAT
CAGCAAAAACAGTAAGAATACTGTCGTTGTCATGTCCATTAAGGACTTTGAAGAACTTGAAGCAATGAAACTCGATTATC
TCAAACACTGCTTTGAGTCTGCTCAGAAAGACTTAGATAGTGGCAAAACCGTTGATGGTGCCACTTTTCTAAACACCCTT
TGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0K9UJR8

Antitoxin

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Source
ID
Structure
AlphaFold DBQ7DCR7

References