58359

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-Phd
Location 398051..398629 Replicon chromosome
Accession NZ_CP013314
Organism Vibrio cholerae strain E9120

Toxin (Protein)


Gene name parE Uniprot ID O68848
Locus tag ASZ79_RS16360 Protein ID WP_001180243.1
Coordinates 398051..398368 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q7DCR7
Locus tag ASZ79_RS16365 Protein ID WP_000557292.1
Coordinates 398387..398629 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ASZ79_RS16310 393242..393637 + 396 WP_000046952.1 hypothetical protein -
ASZ79_RS16315 393940..394121 + 182 Protein_402 DUF645 family protein -
ASZ79_RS16320 394298..394693 + 396 WP_000046953.1 hypothetical protein -
ASZ79_RS16325 394837..395373 + 537 WP_000644491.1 nucleotidyltransferase family protein -
ASZ79_RS16330 395670..395849 + 180 WP_001883039.1 DUF645 family protein -
ASZ79_RS16335 396045..396470 + 426 WP_000403014.1 GNAT family N-acetyltransferase -
ASZ79_RS16340 396619..396966 + 348 WP_000933409.1 hypothetical protein -
ASZ79_RS20640 397113..397406 + 294 WP_125460920.1 hypothetical protein -
ASZ79_RS21005 397762..397857 + 96 WP_001907607.1 DUF645 family protein -
ASZ79_RS16360 398051..398368 - 318 WP_001180243.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ASZ79_RS16365 398387..398629 - 243 WP_000557292.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
ASZ79_RS16370 398871..399380 + 510 WP_000405987.1 GNAT family N-acetyltransferase -
ASZ79_RS16375 399437..400090 + 654 WP_000226874.1 hypothetical protein -
ASZ79_RS16380 400400..400618 + 219 WP_001917086.1 DUF3709 domain-containing protein -
ASZ79_RS16390 401021..401254 + 234 WP_032482776.1 DUF3709 domain-containing protein -
ASZ79_RS16395 401679..401859 + 181 Protein_416 DUF645 family protein -
ASZ79_RS16400 402126..402413 + 288 WP_001162670.1 type II toxin-antitoxin system RelE/ParE family toxin -
ASZ79_RS16405 402424..402741 + 318 WP_001232701.1 HigA family addiction module antidote protein -
ASZ79_RS21010 402738..402848 + 111 WP_134814058.1 DUF3265 domain-containing protein -
ASZ79_RS21015 403025..403150 + 126 WP_001944767.1 DUF645 family protein -
ASZ79_RS21020 403166..403204 + 39 WP_106019119.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 304700..468464 163764
inside Integron - - 309780..468088 158308


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-93)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-71)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12158.97 Da        Isoelectric Point: 9.7495

>T58359 WP_001180243.1 NZ_CP013314:c398368-398051 [Vibrio cholerae]
MQNKQYKLSQLAQEHLLKIKHYTIENFAEAQWQKYKSTLLSGFQTLADNPGLGKSCEDIYQNGFYFPVGKHMAYYTKEAN
FILIVAVLGQSQLPQKHLKQSRFVS

Download         Length: 318 bp

>T58359 NZ_CP013314:c398368-398051 [Vibrio cholerae]
ATGCAAAATAAACAATATAAGCTCAGCCAATTAGCCCAAGAGCACTTACTCAAGATTAAACACTACACCATTGAAAATTT
CGCTGAAGCGCAGTGGCAAAAATATAAGTCGACCTTGCTTTCAGGTTTCCAAACTCTTGCGGATAACCCAGGACTAGGAA
AAAGCTGTGAAGATATTTACCAAAATGGTTTTTACTTTCCAGTGGGGAAACACATGGCTTATTACACCAAAGAAGCAAAC
TTCATTCTCATTGTTGCGGTATTAGGGCAATCACAACTGCCCCAAAAGCATCTCAAACAGTCACGCTTTGTTTCTTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.25 Da        Isoelectric Point: 5.6630

>AT58359 WP_000557292.1 NZ_CP013314:c398629-398387 [Vibrio cholerae]
MHTLTANDAKRNFGELLLSAQREPVIISKNSKNTVVVMSIKDFEELEAMKLDYLKHCFESAQKDLDSGKTVDGATFLNTL

Download         Length: 243 bp

>AT58359 NZ_CP013314:c398629-398387 [Vibrio cholerae]
ATGCACACACTAACAGCAAATGATGCTAAACGAAATTTTGGTGAACTTCTTCTAAGCGCACAACGCGAACCTGTCATCAT
CAGCAAAAACAGTAAGAATACTGTCGTTGTCATGTCCATTAAGGACTTTGAAGAACTTGAAGCAATGAAACTCGATTATC
TCAAACACTGCTTTGAGTCTGCTCAGAAAGACTTAGATAGTGGCAAAACCGTTGATGGTGCCACTTTTCTAAACACCCTT
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0K9UJR8

Antitoxin

Source ID Structure
AlphaFold DB Q7DCR7

References