58223

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 383150..383688 Replicon chromosome
Accession NZ_CP013302
Organism Vibrio cholerae strain C5

Toxin (Protein)


Gene name parE Uniprot ID Q9KMJ0
Locus tag ASZ80_RS16295 Protein ID WP_000802136.1
Coordinates 383150..383449 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P58093
Locus tag ASZ80_RS16300 Protein ID WP_001107719.1
Coordinates 383446..383688 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ASZ80_RS16245 379085..379267 + 183 WP_000923182.1 DUF645 family protein -
ASZ80_RS16250 379467..379940 + 474 WP_001161076.1 GrpB family protein -
ASZ80_RS16255 379955..380047 + 93 WP_014378730.1 DUF3265 domain-containing protein -
ASZ80_RS16260 380089..380715 + 627 WP_000365424.1 LysE family translocator -
ASZ80_RS16265 380838..381536 + 699 WP_001890502.1 hypothetical protein -
ASZ80_RS16270 381546..381656 + 111 WP_079857360.1 DUF3265 domain-containing protein -
ASZ80_RS16285 382234..382413 + 180 WP_001883058.1 DUF645 family protein -
ASZ80_RS16290 382627..383022 + 396 WP_000870857.1 DUF3465 domain-containing protein -
ASZ80_RS16295 383150..383449 - 300 WP_000802136.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ASZ80_RS16300 383446..383688 - 243 WP_001107719.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
ASZ80_RS16305 383917..384495 + 579 WP_000110120.1 hypothetical protein -
ASZ80_RS16310 384517..384609 + 93 WP_014164112.1 DUF3265 domain-containing protein -
ASZ80_RS16320 385033..385716 + 684 WP_000877436.1 hypothetical protein -
ASZ80_RS16325 385930..386196 + 267 WP_000937852.1 hypothetical protein -
ASZ80_RS16330 386351..386950 + 600 WP_000429495.1 hypothetical protein -
ASZ80_RS16335 387231..388166 + 936 WP_000051985.1 restriction endonuclease -
ASZ80_RS16340 388132..388272 + 141 WP_001883049.1 DUF3265 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 304694..469286 164592
inside Integron - - 309774..468910 159136


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-92)

Antitoxin

Antitoxin ParD

(1-79)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11589.29 Da        Isoelectric Point: 9.9232

>T58223 WP_000802136.1 NZ_CP013302:c383449-383150 [Vibrio cholerae]
MKPFNLTVAAKADLRDIALFTQRRWGKEQRNVYLKQFDDSFWLLAENPDIGKSCDEIREGYRKFPQGSHVIFYQQTGSQQ
IRVIRILHKSMDVNPIFGA

Download         Length: 300 bp

>T58223 NZ_CP013302:c383449-383150 [Vibrio cholerae]
ATGAAACCATTTAATCTTACCGTCGCCGCCAAAGCCGATTTACGTGATATTGCTTTATTCACTCAACGACGCTGGGGAAA
AGAGCAGCGAAATGTTTATTTAAAGCAATTCGATGATTCCTTTTGGCTTTTAGCGGAAAATCCCGACATTGGTAAATCAT
GCGATGAAATCCGAGAGGGATACAGAAAATTTCCCCAAGGGAGTCACGTCATCTTTTATCAGCAAACCGGCAGCCAACAA
ATCAGGGTGATCCGAATTCTTCATAAGAGCATGGATGTGAACCCAATATTCGGCGCATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8964.84 Da        Isoelectric Point: 4.1677

>AT58223 WP_001107719.1 NZ_CP013302:c383688-383446 [Vibrio cholerae]
MAKNTSITLGEHFDGFITSQIQSGRYGSASEVIRSALRLLENQETKLQSLRQLLIEGEQSGDADYDLDSFINELDSENIR

Download         Length: 243 bp

>AT58223 NZ_CP013302:c383688-383446 [Vibrio cholerae]
ATGGCTAAAAATACAAGTATCACTCTTGGTGAACACTTCGATGGCTTTATTACAAGCCAAATACAAAGTGGGCGTTACGG
CTCAGCAAGTGAAGTCATTCGCTCTGCGCTACGTCTACTCGAAAACCAAGAAACCAAACTACAGTCACTCCGTCAACTAC
TTATTGAAGGAGAGCAAAGTGGTGACGCTGATTATGACCTTGATAGCTTCATCAATGAACTCGATAGTGAAAACATTCGA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7R5A

Antitoxin

Source ID Structure
AlphaFold DB A0A151JFU4

References