Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /GNAT-DUF1778
Location 910735..911501 Replicon chromosome
Accession NZ_LT992487
Organism Vibrio cholerae strain 4295STDY6534216

Toxin (Protein)


Gene name - Uniprot ID Q9K2P7
Locus tag DG247_RS18460 Protein ID WP_000982260.1
Coordinates 911004..911501 (+) Length 166 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q9K2J6
Locus tag DG247_RS18455 Protein ID WP_000246253.1
Coordinates 910735..911007 (+) Length 91 a.a.

Genomic Context

DG247_RS18455DG247_RS18460DG247_RS18410DG247_RS18415DG247_RS18420DG247_RS18430DG247_RS18435DG247_RS18440DG247_RS18445DG247_RS18450DG247_RS18470DG247_RS18475DG247_RS18480DG247_RS18485DG247_RS18490DG247_RS18495DG247_RS18500DG247_RS18505DG247_RS18510
Location: 910735..911007 (273 bp)
Type: Antitoxin
Protein ID: WP_000246253.1
Location: 911004..911501 (498 bp)
Type: Toxin
Protein ID: WP_000982260.1
Location: 905963..906880 (918 bp)
Type: Others
Protein ID: WP_000186333.1
Location: 907114..907416 (303 bp)
Type: Others
Protein ID: WP_000229317.1
Location: 907404..907661 (258 bp)
Type: Others
Protein ID: WP_000861987.1
Location: 907863..908396 (534 bp)
Type: Others
Protein ID: WP_000118351.1
Location: 908393..908818 (426 bp)
Type: Others
Protein ID: WP_001882332.1
Location: 908885..909256 (372 bp)
Type: Others
Protein ID: WP_001164080.1
Location: 909397..909684 (288 bp)
Type: Others
Protein ID: WP_000426470.1
Location: 909836..910504 (669 bp)
Type: Others
Protein ID: WP_000043871.1
Location: 911703..911855 (153 bp)
Type: Others
Protein ID: WP_001884520.1
Location: 912177..912632 (456 bp)
Type: Others
Protein ID: WP_001245327.1
Location: 912760..913047 (288 bp)
Type: Others
Protein ID: WP_000221354.1
Location: 913037..913288 (252 bp)
Type: Others
Protein ID: WP_001250179.1
Location: 913502..913915 (414 bp)
Type: Others
Protein ID: WP_000049417.1
Location: 913990..914133 (144 bp)
Type: Others
Protein ID: WP_071908341.1
Location: 914103..914504 (402 bp)
Type: Others
Protein ID: WP_000351248.1
Location: 914504..915196 (693 bp)
Type: Others
Protein ID: WP_001047169.1
Location: 915333..915639 (307 bp)
Type: Others
Protein ID: Protein_787
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
DG247_RS18410905963..906880-918WP_000186333.1alpha/beta hydrolase-
DG247_RS18415907114..907416-303WP_000229317.1type II toxin-antitoxin system RelE/ParE family toxin-
DG247_RS18420907404..907661-258WP_000861987.1type II toxin-antitoxin system Phd/YefM family antitoxin-
DG247_RS18430907863..908396-534WP_000118351.1GNAT family N-acetyltransferase-
DG247_RS18435908393..908818-426WP_001882332.1DUF1778 domain-containing protein-
DG247_RS18440908885..909256-372WP_001164080.1nucleotide pyrophosphohydrolase-
DG247_RS18445909397..909684-288WP_000426470.1hypothetical protein-
DG247_RS18450909836..910504-669WP_000043871.1hypothetical protein-
DG247_RS18455910735..911007+273WP_000246253.1DUF1778 domain-containing proteinAntitoxin
DG247_RS18460911004..911501+498WP_000982260.1GNAT family N-acetyltransferaseToxin
DG247_RS18470911703..911855-153WP_001884520.1DUF645 family protein-
DG247_RS18475912177..912632-456WP_001245327.1GNAT family N-acetyltransferase-
DG247_RS18480912760..913047-288WP_000221354.1type II toxin-antitoxin system RelE/ParE family toxin-
DG247_RS18485913037..913288-252WP_001250179.1type II toxin-antitoxin system Phd/YefM family antitoxin-
DG247_RS18490913502..913915-414WP_000049417.1VOC family protein-
DG247_RS18495913990..914133-144WP_071908341.1DUF3265 domain-containing protein-
DG247_RS18500914103..914504-402WP_000351248.1type II toxin-antitoxin system death-on-curing family toxin-
DG247_RS18505914504..915196-693WP_001047169.1GNAT family N-acetyltransferase-
DG247_RS18510915333..915639-307Protein_787CatB-related O-acetyltransferase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-897525..99449796972
insideIntegroncatB9-897901..98770989808
flankIS/Tn--915707..916687980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(86-152)

Antitoxin

Vibrio phage ICP1, Orf50

(7-86)


Sequences

Toxin        


Download         Length: 166 a.a.        Molecular weight: 18527.18 Da        Isoelectric Point: 8.7753

>T294353 WP_000982260.1 NZ_LT992487:911004-911501 [Vibrio cholerae]
MMNTVLLDKDKHDRNRFNCGTEALNNYLKVMASQQAKKDNTRTFVLEDDNNSAYIIGFYTLTMTPIDLKALPDKLQKKHQ
SSTSGGLIARLAVDDRYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKHFYERYGFQAFQDAENKLFITIADI
RASLG

Download         Length: 498 bp

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9683.22 Da        Isoelectric Point: 6.2988

>AT294353 WP_000246253.1 NZ_LT992487:910735-911007 [Vibrio cholerae]
MATTLPRITARVDVDTQDLLAKAAALAGMSSINSFVLNAAIEKAKQVIEREQALKLSQADAVLLMEALDNPAVVNAKLKL
ASERYESKTQ

Download         Length: 273 bp


Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0Q0KGB1

Antitoxin

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Source
ID
Structure
PDB1Y9B
AlphaFold DBA0A0F2IC79

References