26157

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-Phd
Location 425446..425993 Replicon chromosome II
Accession NC_016945
Organism Vibrio cholerae IEC224

Toxin (Protein)


Gene name relE Uniprot ID Q9KM92
Locus tag O3Y_RS16230 Protein ID WP_000229317.1
Coordinates 425691..425993 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9KM93
Locus tag O3Y_RS16225 Protein ID WP_000861987.1
Coordinates 425446..425703 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O3Y_RS16180 420475..420930 + 456 WP_001245327.1 GNAT family N-acetyltransferase -
O3Y_RS16185 421252..421404 + 153 WP_001884520.1 DUF645 family protein -
O3Y_RS16190 421606..422103 - 498 WP_000982260.1 GNAT family N-acetyltransferase -
O3Y_RS16195 422100..422372 - 273 WP_000246253.1 DUF1778 domain-containing protein -
O3Y_RS16200 422603..423271 + 669 WP_000043871.1 hypothetical protein -
O3Y_RS16205 423423..423710 + 288 WP_000426470.1 hypothetical protein -
O3Y_RS16210 423851..424222 + 372 WP_001164080.1 nucleotide pyrophosphohydrolase -
O3Y_RS16215 424289..424714 + 426 WP_001882332.1 DUF1778 domain-containing protein -
O3Y_RS16220 424711..425244 + 534 WP_000118351.1 GNAT family N-acetyltransferase -
O3Y_RS16225 425446..425703 + 258 WP_000861987.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
O3Y_RS16230 425691..425993 + 303 WP_000229317.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
O3Y_RS16235 426227..427144 + 918 WP_000186333.1 alpha/beta hydrolase -
O3Y_RS16240 427301..427690 + 390 WP_001081302.1 hypothetical protein -
O3Y_RS16245 427826..428035 + 210 Protein_464 GNAT family N-acetyltransferase -
O3Y_RS16250 428154..428591 + 438 WP_000503169.1 IS200/IS605-like element IS1004 family transposase -
O3Y_RS16255 428655..428873 + 219 WP_071908318.1 GNAT family N-acetyltransferase -
O3Y_RS16260 429048..429920 + 873 WP_000254716.1 DUF3800 domain-containing protein -
O3Y_RS16265 430070..430669 + 600 WP_001891245.1 glutathione S-transferase N-terminal domain-containing protein -
O3Y_RS20350 430726..430830 + 105 WP_099607150.1 acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 304637..435582 130945
inside Integron - - 309717..435206 125489
flank IS/Tn - - 428154..428591 437


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-69)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11726.68 Da        Isoelectric Point: 5.1972

>T26157 WP_000229317.1 NC_016945:425691-425993 [Vibrio cholerae IEC224]
MVEIIWTELALSDLNDIAEYIALENVVAAKQLVQTVFTKVERLADFPESGRVPPELEHLNYREVVVSPCRVFYKYDDAKV
RILFVMRAERDLRRLMLTKQ

Download         Length: 303 bp

>T26157 NC_016945:425691-425993 [Vibrio cholerae IEC224]
ATGGTTGAAATAATTTGGACGGAGCTGGCTCTATCCGACTTGAATGATATTGCTGAATACATCGCGCTTGAAAATGTCGT
GGCTGCTAAACAACTGGTGCAAACCGTTTTTACAAAAGTTGAACGTTTGGCCGATTTTCCAGAGTCTGGGCGCGTCCCTC
CAGAACTAGAACACCTCAATTATCGTGAAGTCGTTGTAAGTCCGTGTCGTGTTTTCTACAAGTATGATGATGCAAAGGTT
CGTATTCTTTTTGTTATGCGTGCGGAGCGAGATTTGCGTCGGTTAATGCTTACGAAACAGTAG

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9647.15 Da        Isoelectric Point: 7.3178

>AT26157 WP_000861987.1 NC_016945:425446-425703 [Vibrio cholerae IEC224]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLIDVDDYEFMQNRLAILEGIARGERALADGKVVSHQDAKDRM
SKWLK

Download         Length: 258 bp

>AT26157 NC_016945:425446-425703 [Vibrio cholerae IEC224]
ATGAAAGTAGAACTTGTGACGTCACTAAAACGTCAGGCCACTAAGATCCTTGCCGATCTTCATGATACGAAAGAGCCAGT
ATTGATAACTGAGCACGGAAAACCGTCAGCTTACCTTATTGATGTAGACGACTATGAATTTATGCAAAATCGTTTAGCGA
TCCTGGAAGGTATTGCTCGCGGAGAGCGAGCTTTAGCGGATGGTAAAGTGGTCAGCCATCAAGATGCTAAGGACAGAATG
TCAAAATGGTTGAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q9KM92

Antitoxin

Source ID Structure
AlphaFold DB A0A1T4SLM9

References