Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-Phd
Location 425446..425993 Replicon chromosome II
Accession NC_016945
Organism Vibrio cholerae IEC224

Toxin (Protein)


Gene name relE Uniprot ID Q9KM92
Locus tag O3Y_RS16230 Protein ID WP_000229317.1
Coordinates 425691..425993 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9KM93
Locus tag O3Y_RS16225 Protein ID WP_000861987.1
Coordinates 425446..425703 (+) Length 86 a.a.

Genomic Context

O3Y_RS16180O3Y_RS16185O3Y_RS16200O3Y_RS16205O3Y_RS16210O3Y_RS16215O3Y_RS16220O3Y_RS16225O3Y_RS16230O3Y_RS16235O3Y_RS16240O3Y_RS16245O3Y_RS16250O3Y_RS16255O3Y_RS16260O3Y_RS16265O3Y_RS20350O3Y_RS16190O3Y_RS16195
Location: 420475..420930 (456 bp)
Type: Others
Protein ID: WP_001245327.1
Location: 421252..421404 (153 bp)
Type: Others
Protein ID: WP_001884520.1
Location: 422603..423271 (669 bp)
Type: Others
Protein ID: WP_000043871.1
Location: 423423..423710 (288 bp)
Type: Others
Protein ID: WP_000426470.1
Location: 423851..424222 (372 bp)
Type: Others
Protein ID: WP_001164080.1
Location: 424289..424714 (426 bp)
Type: Others
Protein ID: WP_001882332.1
Location: 424711..425244 (534 bp)
Type: Others
Protein ID: WP_000118351.1
Location: 425446..425703 (258 bp)
Type: Antitoxin
Protein ID: WP_000861987.1
Location: 425691..425993 (303 bp)
Type: Toxin
Protein ID: WP_000229317.1
Location: 426227..427144 (918 bp)
Type: Others
Protein ID: WP_000186333.1
Location: 427301..427690 (390 bp)
Type: Others
Protein ID: WP_001081302.1
Location: 427826..428035 (210 bp)
Type: Others
Protein ID: Protein_464
Location: 428154..428591 (438 bp)
Type: Others
Protein ID: WP_000503169.1
Location: 428655..428873 (219 bp)
Type: Others
Protein ID: WP_071908318.1
Location: 429048..429920 (873 bp)
Type: Others
Protein ID: WP_000254716.1
Location: 430070..430669 (600 bp)
Type: Others
Protein ID: WP_001891245.1
Location: 430726..430830 (105 bp)
Type: Others
Protein ID: WP_099607150.1
Location: 421606..422103 (498 bp)
Type: Others
Protein ID: WP_000982260.1
Location: 422100..422372 (273 bp)
Type: Others
Protein ID: WP_000246253.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
O3Y_RS16180420475..420930+456WP_001245327.1GNAT family N-acetyltransferase-
O3Y_RS16185421252..421404+153WP_001884520.1DUF645 family protein-
O3Y_RS16190421606..422103-498WP_000982260.1GNAT family N-acetyltransferase-
O3Y_RS16195422100..422372-273WP_000246253.1DUF1778 domain-containing protein-
O3Y_RS16200422603..423271+669WP_000043871.1hypothetical protein-
O3Y_RS16205423423..423710+288WP_000426470.1hypothetical protein-
O3Y_RS16210423851..424222+372WP_001164080.1nucleotide pyrophosphohydrolase-
O3Y_RS16215424289..424714+426WP_001882332.1DUF1778 domain-containing protein-
O3Y_RS16220424711..425244+534WP_000118351.1GNAT family N-acetyltransferase-
O3Y_RS16225425446..425703+258WP_000861987.1type II toxin-antitoxin system Phd/YefM family antitoxinAntitoxin
O3Y_RS16230425691..425993+303WP_000229317.1type II toxin-antitoxin system RelE/ParE family toxinToxin
O3Y_RS16235426227..427144+918WP_000186333.1alpha/beta hydrolase-
O3Y_RS16240427301..427690+390WP_001081302.1hypothetical protein-
O3Y_RS16245427826..428035+210Protein_464GNAT family N-acetyltransferase-
O3Y_RS16250428154..428591+438WP_000503169.1IS200/IS605-like element IS1004 family transposase-
O3Y_RS16255428655..428873+219WP_071908318.1GNAT family N-acetyltransferase-
O3Y_RS16260429048..429920+873WP_000254716.1DUF3800 domain-containing protein-
O3Y_RS16265430070..430669+600WP_001891245.1glutathione S-transferase N-terminal domain-containing protein-
O3Y_RS20350430726..430830+105WP_099607150.1acetyltransferase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-304637..435582130945
insideIntegron--309717..435206125489
flankIS/Tn--428154..428591437


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-69)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11726.68 Da        Isoelectric Point: 5.1972

>T26157 WP_000229317.1 NC_016945:425691-425993 [Vibrio cholerae IEC224]
MVEIIWTELALSDLNDIAEYIALENVVAAKQLVQTVFTKVERLADFPESGRVPPELEHLNYREVVVSPCRVFYKYDDAKV
RILFVMRAERDLRRLMLTKQ

Download         Length: 303 bp

>T26157 NC_016945:425691-425993 [Vibrio cholerae IEC224]
ATGGTTGAAATAATTTGGACGGAGCTGGCTCTATCCGACTTGAATGATATTGCTGAATACATCGCGCTTGAAAATGTCGT
GGCTGCTAAACAACTGGTGCAAACCGTTTTTACAAAAGTTGAACGTTTGGCCGATTTTCCAGAGTCTGGGCGCGTCCCTC
CAGAACTAGAACACCTCAATTATCGTGAAGTCGTTGTAAGTCCGTGTCGTGTTTTCTACAAGTATGATGATGCAAAGGTT
CGTATTCTTTTTGTTATGCGTGCGGAGCGAGATTTGCGTCGGTTAATGCTTACGAAACAGTAG

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9647.15 Da        Isoelectric Point: 7.3178

>AT26157 WP_000861987.1 NC_016945:425446-425703 [Vibrio cholerae IEC224]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLIDVDDYEFMQNRLAILEGIARGERALADGKVVSHQDAKDRM
SKWLK

Download         Length: 258 bp

>AT26157 NC_016945:425446-425703 [Vibrio cholerae IEC224]
ATGAAAGTAGAACTTGTGACGTCACTAAAACGTCAGGCCACTAAGATCCTTGCCGATCTTCATGATACGAAAGAGCCAGT
ATTGATAACTGAGCACGGAAAACCGTCAGCTTACCTTATTGATGTAGACGACTATGAATTTATGCAAAATCGTTTAGCGA
TCCTGGAAGGTATTGCTCGCGGAGAGCGAGCTTTAGCGGATGGTAAAGTGGTCAGCCATCAAGATGCTAAGGACAGAATG
TCAAAATGGTTGAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBQ9KM92

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A1T4SLM9

References