38626

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc(toxin)
Location 96875..97446 Replicon chromosome
Accession NZ_AP024548
Organism Vibrio cholerae strain BCH-01536

Toxin (Protein)


Gene name doc Uniprot ID Q9KMA2
Locus tag K6J77_RS14640 Protein ID WP_000351248.1
Coordinates 97045..97446 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID Q8GNG3
Locus tag K6J77_RS19085 Protein ID WP_001080654.1
Coordinates 96875..97045 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6J77_RS14585 92070..92184 + 115 Protein_170 acetyltransferase -
K6J77_RS14590 92193..92414 + 222 WP_032468461.1 DUF1289 domain-containing protein -
K6J77_RS14595 92580..92693 + 114 WP_001889158.1 hypothetical protein -
K6J77_RS14600 92642..92869 + 228 WP_073426587.1 DUF1289 domain-containing protein -
K6J77_RS14605 93210..93542 + 333 WP_000843587.1 type II toxin-antitoxin system RelE/ParE family toxin -
K6J77_RS14610 93529..93843 + 315 WP_000071008.1 DNA-binding transcriptional regulator -
K6J77_RS14615 93980..94414 + 435 WP_000256036.1 GNAT family N-acetyltransferase -
K6J77_RS14620 94582..94737 + 156 WP_000751734.1 hypothetical protein -
K6J77_RS14625 94862..95842 - 981 WP_000019370.1 IS5-like element ISVch5 family transposase -
K6J77_RS14630 95910..96216 + 307 Protein_179 CatB-related O-acetyltransferase -
K6J77_RS19080 96353..96751 + 399 Protein_180 GNAT family N-acetyltransferase -
K6J77_RS19085 96875..97045 + 171 WP_001080654.1 hypothetical protein Antitoxin
K6J77_RS14640 97045..97446 + 402 WP_000351248.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
K6J77_RS19090 97449..97559 + 111 WP_082798255.1 DUF3265 domain-containing protein -
K6J77_RS14645 97634..98047 + 414 WP_000049417.1 VOC family protein -
K6J77_RS14650 98261..98512 + 252 WP_001250179.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
K6J77_RS14655 98502..98789 + 288 WP_000221354.1 type II toxin-antitoxin system RelE/ParE family toxin -
K6J77_RS14660 98917..99372 + 456 WP_001245327.1 GNAT family N-acetyltransferase -
K6J77_RS19095 99429..99551 + 123 Protein_188 acetyltransferase -
K6J77_RS14665 99722..99846 + 125 Protein_189 DUF645 family protein -
K6J77_RS19100 99963..100031 + 69 Protein_190 acetyltransferase -
K6J77_RS14670 100048..100545 - 498 WP_000982260.1 GNAT family N-acetyltransferase -
K6J77_RS14675 100542..100814 - 273 WP_000246253.1 DUF1778 domain-containing protein -
K6J77_RS19105 100966..101028 + 63 Protein_193 acetyltransferase -
K6J77_RS14680 101045..101713 + 669 WP_000043871.1 hypothetical protein -
K6J77_RS14685 101865..102152 + 288 WP_000426470.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Integron - - 11978..113648 101670
flank IS/Tn - - 94862..95842 980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(1-132)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14608.71 Da        Isoelectric Point: 4.0128

>T38626 WP_000351248.1 NZ_AP024548:97045-97446 [Vibrio cholerae]
MDIICFPFERVIEINAFILKTEPGMKGAVDIPKLQGALGRIDNAIVYEGLDDVFEIAAKYTACIAVSHALPDANKRTGLA
VALEYLSLNDFELTQENDLLADAVRDLVIGIINETDFADILYAQYAKEQNSAL

Download         Length: 402 bp

>T38626 NZ_AP024548:97045-97446 [Vibrio cholerae]
ATGGATATCATCTGTTTTCCTTTTGAACGAGTGATCGAGATTAATGCTTTCATCCTAAAAACAGAACCAGGAATGAAAGG
AGCCGTTGATATTCCCAAGCTTCAGGGGGCATTAGGTCGAATCGATAATGCCATCGTTTATGAAGGACTGGATGATGTTT
TTGAAATCGCTGCTAAATACACTGCTTGTATAGCGGTTTCACATGCGCTACCTGATGCGAACAAACGCACAGGTTTGGCT
GTGGCACTTGAATATTTATCACTTAACGATTTTGAGCTTACGCAGGAAAACGATTTACTTGCGGATGCAGTTCGAGATCT
TGTTATCGGCATTATCAACGAAACAGATTTTGCCGACATTCTCTACGCACAATACGCAAAAGAACAAAATTCAGCTCTCT
AA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6287.35 Da        Isoelectric Point: 10.7274

>AT38626 WP_001080654.1 NZ_AP024548:96875-97045 [Vibrio cholerae]
MNRKVEAYGVDAVERPKIKASKKLDLTGDAGRQIVKSETKLALRTHQKTFTKLADM

Download         Length: 171 bp

>AT38626 NZ_AP024548:96875-97045 [Vibrio cholerae]
ATGAATCGAAAAGTTGAAGCTTACGGCGTTGATGCTGTTGAAAGACCGAAAATTAAGGCTAGTAAAAAGCTTGATTTGAC
TGGTGATGCTGGTCGTCAAATTGTGAAGTCTGAAACTAAACTTGCTTTGCGTACTCATCAGAAGACATTCACTAAATTGG
CTGATATGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Q0PN34

Antitoxin

Source ID Structure
AlphaFold DB A0A1T4SJJ1

References