95386

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 120471..120999 Replicon chromosome
Accession NZ_CP026648
Organism Vibrio cholerae O1 biovar El Tor strain HC1037

Toxin (Protein)


Gene name relE Uniprot ID A0A0X1KZS6
Locus tag C4E16_RS15175 Protein ID WP_000221354.1
Coordinates 120712..120999 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0X1KZS8
Locus tag C4E16_RS15170 Protein ID WP_001250179.1
Coordinates 120471..120722 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C4E16_RS15130 115739..116053 + 315 WP_000071008.1 DNA-binding transcriptional regulator -
C4E16_RS15135 116190..116624 + 435 WP_000256036.1 GNAT family N-acetyltransferase -
C4E16_RS19445 116792..116947 + 156 WP_000751734.1 hypothetical protein -
C4E16_RS15140 117072..118052 - 981 WP_000019370.1 IS5-like element ISVch5 family transposase -
C4E16_RS15145 118120..118426 + 307 Protein_182 CatB-related O-acetyltransferase -
C4E16_RS15150 118563..119255 + 693 WP_001047169.1 GNAT family N-acetyltransferase -
C4E16_RS15155 119255..119656 + 402 WP_000351248.1 type II toxin-antitoxin system death-on-curing family toxin -
C4E16_RS15160 119626..119769 + 144 WP_071908341.1 DUF3265 domain-containing protein -
C4E16_RS15165 119844..120257 + 414 WP_000049417.1 VOC family protein -
C4E16_RS15170 120471..120722 + 252 WP_001250179.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
C4E16_RS15175 120712..120999 + 288 WP_000221354.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
C4E16_RS15180 121127..121582 + 456 WP_001245327.1 GNAT family N-acetyltransferase -
C4E16_RS15185 121904..122056 + 153 WP_001884520.1 DUF645 family protein -
C4E16_RS15195 122258..122755 - 498 WP_000982260.1 GNAT family N-acetyltransferase -
C4E16_RS15200 122752..123024 - 273 WP_000246253.1 DUF1778 domain-containing protein -
C4E16_RS15205 123255..123923 + 669 WP_000043871.1 hypothetical protein -
C4E16_RS15210 124075..124362 + 288 WP_000426470.1 hypothetical protein -
C4E16_RS15215 124503..124874 + 372 WP_001164080.1 nucleotide pyrophosphohydrolase -
C4E16_RS19585 124941..125366 + 426 WP_001882332.1 DUF1778 domain-containing protein -
C4E16_RS15225 125363..125896 + 534 WP_000118351.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 31043..136234 105191
inside Integron - - 36123..135858 99735
flank IS/Tn - - 117072..118052 980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(11-71)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10991.96 Da        Isoelectric Point: 10.4934

>T95386 WP_000221354.1 NZ_CP026648:120712-120999 [Vibrio cholerae O1 biovar El Tor]
MTYKLKFLPAAQKEWSKLAPTIQSQFKKKLKERLENPHVPSAKLRGYDAVYKIKLRTAGYRLAYEVIDDEIVVYVLAVGK
RDKDAVYKKLASRFG

Download         Length: 288 bp

>T95386 NZ_CP026648:120712-120999 [Vibrio cholerae O1 biovar El Tor]
ATGACCTATAAGTTAAAGTTTCTGCCGGCTGCGCAAAAGGAATGGAGTAAGTTAGCTCCGACAATTCAGAGTCAGTTCAA
GAAGAAGTTAAAGGAACGATTAGAAAATCCGCACGTCCCTTCGGCTAAGCTTCGAGGATACGACGCTGTTTACAAGATTA
AACTTCGTACGGCGGGTTATCGTTTAGCTTATGAGGTTATTGACGATGAGATAGTTGTCTATGTCCTTGCTGTCGGTAAA
CGTGACAAAGATGCTGTCTATAAAAAACTGGCTTCACGCTTCGGTTAG

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9136.29 Da        Isoelectric Point: 4.0197

>AT95386 WP_001250179.1 NZ_CP026648:120471-120722 [Vibrio cholerae O1 biovar El Tor]
MRQVLANCSASISELKKNPTALLNEADGSAIAILNHNKPAAYLVPAETYEYLIDMLDDYELSQIVDSRRADLAQAVEVNI
DDL

Download         Length: 252 bp

>AT95386 NZ_CP026648:120471-120722 [Vibrio cholerae O1 biovar El Tor]
ATGAGACAAGTTTTAGCGAATTGCTCTGCAAGTATTTCAGAGTTAAAGAAGAACCCAACAGCTTTGTTGAATGAGGCTGA
TGGGTCTGCAATTGCAATTTTAAACCACAACAAGCCAGCGGCTTACCTTGTGCCAGCGGAAACGTATGAGTATCTCATCG
ATATGCTCGATGATTATGAGCTTTCCCAAATTGTCGATAGTCGCCGAGCTGACTTAGCACAAGCTGTGGAAGTAAATATT
GATGACCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0X1KZS6

Antitoxin

Source ID Structure
AlphaFold DB A0A0X1KZS8

References