145878

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-Phd
Location 401000..401547 Replicon chromosome
Accession NZ_CP047302
Organism Vibrio cholerae O1 biovar El Tor strain DRC-193A

Toxin (Protein)


Gene name relE Uniprot ID Q9KM92
Locus tag GTF75_RS16040 Protein ID WP_000229317.1
Coordinates 401245..401547 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9KM93
Locus tag GTF75_RS16035 Protein ID WP_000861987.1
Coordinates 401000..401257 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GTF75_RS15990 396029..396484 + 456 WP_001245327.1 GNAT family N-acetyltransferase -
GTF75_RS15995 396806..396958 + 153 WP_001884520.1 DUF645 family protein -
GTF75_RS16000 397160..397657 - 498 WP_000982260.1 GNAT family N-acetyltransferase -
GTF75_RS16005 397654..397926 - 273 WP_000246253.1 DUF1778 domain-containing protein -
GTF75_RS16010 398157..398825 + 669 WP_000043871.1 hypothetical protein -
GTF75_RS16015 398977..399264 + 288 WP_000426470.1 hypothetical protein -
GTF75_RS16020 399405..399776 + 372 WP_001164080.1 nucleotide pyrophosphohydrolase -
GTF75_RS16025 399843..400268 + 426 WP_001882332.1 DUF1778 domain-containing protein -
GTF75_RS16030 400265..400798 + 534 WP_000118351.1 GNAT family N-acetyltransferase -
GTF75_RS16035 401000..401257 + 258 WP_000861987.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
GTF75_RS16040 401245..401547 + 303 WP_000229317.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GTF75_RS16045 401781..402698 + 918 WP_000186333.1 alpha/beta hydrolase -
GTF75_RS16050 402855..403244 + 390 WP_001081302.1 hypothetical protein -
GTF75_RS16055 403380..403589 + 210 Protein_430 GNAT family N-acetyltransferase -
GTF75_RS16060 403708..404145 + 438 WP_000503169.1 IS200/IS605-like element IS1004 family transposase -
GTF75_RS16065 404209..404427 + 219 WP_071908318.1 GNAT family N-acetyltransferase -
GTF75_RS16070 404602..405474 + 873 WP_000254716.1 DUF3800 domain-containing protein -
GTF75_RS16075 405624..406223 + 600 WP_001891245.1 glutathione S-transferase N-terminal domain-containing protein -
GTF75_RS16080 406280..406384 + 105 WP_099607150.1 acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 305935..411136 105201
inside Integron - - 311015..410760 99745
flank IS/Tn - - 403708..404145 437


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-69)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11726.68 Da        Isoelectric Point: 5.1972

>T145878 WP_000229317.1 NZ_CP047302:401245-401547 [Vibrio cholerae O1 biovar El Tor]
MVEIIWTELALSDLNDIAEYIALENVVAAKQLVQTVFTKVERLADFPESGRVPPELEHLNYREVVVSPCRVFYKYDDAKV
RILFVMRAERDLRRLMLTKQ

Download         Length: 303 bp

>T145878 NZ_CP062705:c3587495-3587340 [Escherichia coli O157:H7]
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTGATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTACGAGTCCGAACCGGCCAGACGGAGGTCGCTGTCTTCACAGCTTACGAACCTGAGGAGTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9647.15 Da        Isoelectric Point: 7.3178

>AT145878 WP_000861987.1 NZ_CP047302:401000-401257 [Vibrio cholerae O1 biovar El Tor]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLIDVDDYEFMQNRLAILEGIARGERALADGKVVSHQDAKDRM
SKWLK

Download         Length: 258 bp

>AT145878 NZ_CP062705:3587507-3587565 [Escherichia coli O157:H7]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTAGATTTGCCGTTCATAGATTGAGCCTCA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q9KM92

Antitoxin

Source ID Structure
AlphaFold DB A0A1T4SLM9

References