Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 419942..420470 Replicon chromosome
Accession NZ_OW443148
Organism Vibrio cholerae strain CNRVC190243 isolate YE-NCPHL-19014-PI

Toxin (Protein)


Gene name relE Uniprot ID H9L4R3
Locus tag OC617_RS16035 Protein ID WP_000221352.1
Coordinates 419942..420232 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID H9L4T4
Locus tag OC617_RS16040 Protein ID WP_000213183.1
Coordinates 420222..420470 (-) Length 83 a.a.

Genomic Context

OC617_RS15985OC617_RS15990OC617_RS15995OC617_RS16000OC617_RS16005OC617_RS16010OC617_RS16015OC617_RS16020OC617_RS16025OC617_RS16030OC617_RS16045OC617_RS16050OC617_RS16055OC617_RS16060OC617_RS16065OC617_RS16070OC617_RS16035OC617_RS16040OC617_RS16075
Location: 415212..415322 (111 bp)
Type: Others
Protein ID: WP_134814058.1
Location: 415361..415471 (111 bp)
Type: Others
Protein ID: Protein_420
Location: 415499..415624 (126 bp)
Type: Others
Protein ID: WP_001944767.1
Location: 415587..415703 (117 bp)
Type: Others
Protein ID: WP_001889170.1
Location: 415891..416895 (1005 bp)
Type: Others
Protein ID: WP_000964925.1
Location: 417048..417494 (447 bp)
Type: Others
Protein ID: WP_000128977.1
Location: 417614..418543 (930 bp)
Type: Others
Protein ID: WP_000335802.1
Location: 418540..418650 (111 bp)
Type: Others
Protein ID: WP_071917832.1
Location: 418678..419154 (477 bp)
Type: Others
Protein ID: WP_001047180.1
Location: 419345..419806 (462 bp)
Type: Others
Protein ID: WP_001911752.1
Location: 421041..421694 (654 bp)
Type: Others
Protein ID: WP_000036957.1
Location: 421966..422391 (426 bp)
Type: Others
Protein ID: WP_000415748.1
Location: 422599..422994 (396 bp)
Type: Others
Protein ID: WP_000649527.1
Location: 423145..423675 (531 bp)
Type: Others
Protein ID: WP_000415563.1
Location: 423813..424313 (501 bp)
Type: Others
Protein ID: WP_000789723.1
Location: 424469..424867 (399 bp)
Type: Others
Protein ID: WP_001882293.1
Location: 419942..420232 (291 bp)
Type: Toxin
Protein ID: WP_000221352.1
Location: 420222..420470 (249 bp)
Type: Antitoxin
Protein ID: WP_000213183.1
Location: 424967..425431 (465 bp)
Type: Others
Protein ID: WP_000140244.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
OC617_RS15985415212..415322+111WP_134814058.1DUF3265 domain-containing protein-
OC617_RS15990415361..415471+111Protein_420acetyltransferase-
OC617_RS15995415499..415624+126WP_001944767.1DUF645 family protein-
OC617_RS16000415587..415703+117WP_001889170.1hypothetical protein-
OC617_RS16005 (CNRVC190243H_03145)415891..416895+1005WP_000964925.1LD-carboxypeptidase-
OC617_RS16010 (CNRVC190243H_03146)417048..417494+447WP_000128977.1hypothetical protein-
OC617_RS16015 (CNRVC190243H_03147)417614..418543+930WP_000335802.1hypothetical protein-
OC617_RS16020418540..418650+111WP_071917832.1DUF3265 domain-containing protein-
OC617_RS16025 (CNRVC190243H_03148)418678..419154+477WP_001047180.1GNAT family N-acetyltransferase-
OC617_RS16030 (CNRVC190243H_03149)419345..419806+462WP_001911752.1lipocalin family protein-
OC617_RS16035 (CNRVC190243H_03150)419942..420232-291WP_000221352.1type II toxin-antitoxin system RelE/ParE family toxinToxin
OC617_RS16040 (CNRVC190243H_03151)420222..420470-249WP_000213183.1type II toxin-antitoxin system Phd/YefM family antitoxinAntitoxin
OC617_RS16045 (CNRVC190243H_03153)421041..421694+654WP_000036957.1site-specific DNA-methyltransferase-
OC617_RS16050 (CNRVC190243H_03154)421966..422391+426WP_000415748.1hypothetical protein-
OC617_RS16055 (CNRVC190243H_03155)422599..422994+396WP_000649527.1DUF3465 domain-containing protein-
OC617_RS16060 (CNRVC190243H_03156)423145..423675+531WP_000415563.1hypothetical protein-
OC617_RS16065 (CNRVC190243H_03157)423813..424313+501WP_000789723.1hypothetical protein-
OC617_RS16070 (CNRVC190243H_03158)424469..424867+399WP_001882293.1hypothetical protein-
OC617_RS16075 (CNRVC190243H_03159)424967..425431-465WP_000140244.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-349905..456410106505
insideIntegroncatB9-354985..456034101049


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11247.23 Da        Isoelectric Point: 10.4678

>T295394 WP_000221352.1 NZ_OW443148:c420232-419942 [Vibrio cholerae]
MTYKLEFKKSALKEWKKLAVPLQQQFKKKLIERLENPHVPSAKLSGAENIYKIKLRQSGYRLVYQVENDIIVVTVLAVGK
RERSEVYTKALQRLDD

Download         Length: 291 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8937.28 Da        Isoelectric Point: 4.1079

>AT295394 WP_000213183.1 NZ_OW443148:c420470-420222 [Vibrio cholerae]
MTTRILADVAASITEFKANPMKVATSAFGAPVAVLNRNEPAFYCVPASTYEIMMDKLEDLELLAIAKERLSEDSVSVNID
DL

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBH9L4R3

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A366A3W8

References